4-(2-furyl)-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-furyl)-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide
• 英文别名: 4-(furan-2-yl)-N-(6-methoxypyridazin-3-yl)benzenesulfonamide
• 化学式: C₁₅H₁₃N₃O₄S
• 分子量: 331.352
• InChiKey: XFZMJCZAQJVCCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  7

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  磺胺甲氧哒嗪	Sulfamethoxypyridazine	80-35-3	C11H12N4O3S	280.307

反应信息

• 作为产物：
  描述：

  呋喃 、 磺胺甲氧哒嗪 在 盐酸 、 sodium nitrite 作用下， 以 水 、 丙酮 为溶剂， 反应 24.17h， 以36%的产率得到4-(2-furyl)-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide
  参考文献：
  名称：

  Synthesis and evaluation of cytotoxic activity of arylfurans

  摘要：

  A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells. (c) 2006 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.03.010

文献信息

• Synthesis and evaluation of cytotoxic activity of arylfurans
  作者：Renata B. de Oliveira、Elaine M. de Souza-Fagundes、Helen A.J. Siqueira、Rodrigo S. Leite、Claudio L. Donnici、Carlos L. Zani

  DOI：10.1016/j.ejmech.2006.03.010

  日期：2006.6

  A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells. (c) 2006 Elsevier SAS. All rights reserved.