N-acetyl cysteine glycine amide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl cysteine glycine amide
• 英文别名: (2R)-2-acetamido-3-sulfanylpropanoic acid;2-aminoacetamide
• 化学式: C₂H₆N₂O*C₅H₉NO₃S
• 分子量: 237.28
• InChiKey: LITVZOMBOQZAAQ-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.06
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  哌啶 、 N,N-二异丙基乙胺 、 硅烷 、 Ac-S-trityl cysteine 、 Fmoc Rink glycine amide 生成 N-acetyl cysteine glycine amide
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Treatment of multiple sclerosis with brain targeted anti oxidant compounds
  申请人：Atlas Daphne

  公开号：US20060211628A1

  公开（公告）日：2006-09-21

  A method of treating multiple sclerosis, the method comprises administering to a subject in need thereof a therapeutically effective amount of a compound, the compound having: (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.

  一种治疗多发性硬化症的方法，该方法包括向需要该治疗的对象投予治疗有效量的化合物，该化合物具有：（a）分子量和膜亲和性的组合，以便使该化合物穿过生物体的血脑屏障；（b）易于氧化的化学基团，以发挥抗氧化性能；以及（c）化学组成，以便使该化合物或其细胞内衍生物在细胞质内积累。
• Brain targeted low molecular weight hydrophobic anti oxidant compounds
  申请人：——

  公开号：US20020107176A1

  公开（公告）日：2002-08-08

  Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, in which oxidants are overproduced.

  新型脑靶向低分子量疏水性抗氧化剂，将抗氧化剂用于治疗帕金森氏症、阿尔茨海默氏症和克雅氏病等中枢神经系统神经退行性疾病，以及治疗氧化剂过度产生的急性呼吸窘迫综合征、肌萎缩性脊髓侧索硬化症、动脉粥样硬化性心血管疾病和多器官功能障碍等外周组织疾病。
• Treatment of ischemic brain injuries with brain targeted antioxidant compounds
  申请人：——

  公开号：US20030083266A1

  公开（公告）日：2003-05-01

  A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.

  一种减少具有血脑屏障并遭受缺血性脑损伤的生物体脑内氧化应激的方法，该方法包括向该生物体施用一种化合物的步骤，该化合物具有(a)分子量和膜混溶性的组合特性，允许该化合物穿过生物体的血脑屏障；(b)易氧化的化学基团，用于发挥抗氧化特性；以及(c)化学构成，允许该化合物或其细胞内衍生物在细胞的细胞质内积聚。
• TREATMENT OF ISCHEMIC BRAIN INJURIES WITH BRAIN TARGETTED ANTIOXIDANT COMPOUNDS
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM

  公开号：EP1242070A2

  公开（公告）日：2002-09-25
• EP1242070A4
  申请人：——

  公开号：EP1242070A4

  公开（公告）日：2003-05-28