1,2-bis[4-(3,5-dimethylpiperidinomethyl)-3,5-dioxopiperazin-1-yl]-propane

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2-bis[4-(3,5-dimethylpiperidinomethyl)-3,5-dioxopiperazin-1-yl]-propane
• 英文别名: 1-[(3,5-Dimethylpiperidin-1-yl)methyl]-4-[2-[4-[(3,5-dimethylpiperidin-1-yl)methyl]-3,5-dioxopiperazin-1-yl]propyl]piperazine-2,6-dione
• 化学式: C₂₇H₄₆N₆O₄
• 分子量: 518.7
• InChiKey: CKZFWKNNFGVESR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  87.7
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  丙亚胺 生成 1,2-bis[4-(3,5-dimethylpiperidinomethyl)-3,5-dioxopiperazin-1-yl]-propane
  参考文献：
  名称：

  REN, YUN-FENG

  摘要：

  DOI：

文献信息

• Bis-dioxopiperazine derivatives, antitumor agents comprising them and
  申请人：Zenyaki Kogyo Kabushiki Kaisha

  公开号：US04737497A1

  公开（公告）日：1988-04-12

  Disclosed are novel bis-dioxopiperazine derivatives, process for their preparation, antitumor agents comprising them and compositions containing them. The bis-dioxopiperazine derivatives are represented by the following general formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; R.sub.2 represents a hydrogen atom or a group of ##STR2## R.sub.3 and R.sub.4, which are respectively independent and are the same or different, represent respectively a lower alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms or a heterocyclic radical selected from the group consisting of substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino and substituted or unsubstituted thiomorpholino, or R.sub.3 and R.sub.4 are bonded together to form a group of ##STR3## which represents a cyclic amino group selected from the group consisting of substituted or unsubstituted pyrrolidino, substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino, substituted or unsubstituted thiomorpholino and substituted or unsubstituted thiadiazino; and the substituents of the heterocyclic radical and the cyclic amino group are selected from the group consisting of a lower alkyl group having 1 to 4 carbon atoms, oxo and phenyl, said cyclic amino group being not morpholino when R.sub.1 is a hydrogen atom and R.sub.2 is the group of ##STR4##

  本发明涉及新型的双二氧哌嗪衍生物，其制备方法，包含它们的抗肿瘤药物以及含有它们的组合物。双二氧哌嗪衍生物由以下一般式（I）表示：其中R.sub.1代表氢原子或具有1至4个碳原子的较低烷基基团；R.sub.2代表氢原子或##STR2##基团；R.sub.3和R.sub.4分别独立且相同或不同，分别表示具有1至4个碳原子的较低烷基基团，具有3至7个碳原子的环烷基基团或从取代或未取代哌啶基、取代或未取代哌嗪基、取代或未取代吗啉基和取代或未取代硫代吗啉基中选择的杂环基团，或者R.sub.3和R.sub.4结合在一起形成##STR3##基团，表示从取代或未取代吡咯啉基、取代或未取代哌啶基、取代或未取代哌嗪基、取代或未取代吗啉基、取代或未取代硫代吗啉基和取代或未取代噻二唑基中选择的环氨基基团；并且杂环基团和环氨基基团的取代基选择自具有1至4个碳原子的较低烷基基团、氧代基和苯基的群，当R.sub.1为氢原子且R.sub.2为##STR4##基团时，所述环氨基基团不是吗啉基。
• Bis-dioxopiperazine derivatives, process for their preparation, antitumor agents comprising them and compositions containing them
  申请人：ZENYAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0125475A1

  公开（公告）日：1984-11-21

  Disclosed are novel bis-dioxopiperazine derivatives, process for their preparation, antitumor agents comprising them and compositions containing them. The bis-dioxopiperazine derivatives are represented by the following general formula (I): wherein R, represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; R2 represents a hydrogen atom or a group of R3 and R., which are respectively independent and are the same or different, represent respectively a lower alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms or a heterocyclic radical selected from the group consisting of substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino and substituted or unsubstituted thiomorpholino, or R3 and R. are bonded together to form a group of which represents a cyclic amino group selected from the group consisting of substituted or unsubstituted pyrrolidino, substituted or unsubstituted piperidino, substituted or unsubstituted piperazino, substituted or unsubstituted morpholino, substituted or unsubstituted thiomorpholino and substituted or unsubstituted thiadiazino; and the substituents of the heterocyclic radical and the cyclic amino group are selected from the group consisting of a lower alkyl group having 1 to 4 carbon atoms, oxo and phenyl, said cyclic amino group being not morpholino when R, is a hydrogen atom and R2 is the group of

  本发明公开了新型双-二氧代哌嗪衍生物、其制备工艺、包含这些衍生物的抗肿瘤药物以及含有这些衍生物的组合物。 双-二氧代哌嗪衍生物由以下通式（I）表示： 其中 R，代表氢原子或具有 1 至 4 个碳原子的低级烷基； R2 代表氢原子或一个由 R3 和 R.组成的基团。 分别独立且相同或不同的 R3 和 R.分别代表具有 1 至 4 个碳原子的低级烷基、具有 3 至 7 个碳原子的环烷基或选自由取代或未取代的哌啶基、取代或未取代的哌嗪基、取代或未取代的吗啉基和取代或未取代的硫代吗啉基组成的组中的杂环基，或 R3 和 R.键合在一起形成一个基团，该基团代表选自由取代或未取代的哌啶基、取代或未取代的哌嗪基、取代或未取代的吗啉基和取代或未取代的硫代吗啉基组成的组中的杂环基。 代表环状氨基，选自由取代或未取代的吡咯烷基、取代或未取代的哌啶基、取代或未取代的哌嗪基、取代或未取代的吗啉基、取代或未取代的噻吗啉基和取代或未取代的噻二嗪基组成的组；杂环基和环状氨基的取代基选自具有 1 至 4 个碳原子的低级烷基、氧代和苯基组成的组，当 R 为氢原子且 R2 为以下基团时，所述环状氨基不是吗啉基
• NIN, YHPO
  作者：NIN, YHPO

  DOI：——

  日期：——
• REN, YUN-FENG
  作者：REN, YUN-FENG

  DOI：——

  日期：——
• US4737497A
  申请人：——

  公开号：US4737497A

  公开（公告）日：1988-04-12