1,3-dichlor-4-(2,4,6-trimethylbenzyl)-benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dichlor-4-(2,4,6-trimethylbenzyl)-benzene
• 英文别名: 2-[(2,4-Dichlorophenyl)methyl]-1,3,5-trimethylbenzene
• 化学式: C₁₆H₁₆Cl₂
• 分子量: 279.209
• InChiKey: QTTHSVLSWZFTNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,4-二氯苄醇 以 四氢呋喃 为溶剂， 反应 7.5h， 生成 1,3-dichlor-4-(2,4,6-trimethylbenzyl)-benzene
  参考文献：
  名称：

  Uncatalyzed Friedel−Crafts Alkylation of Aromatic Compounds through Reactive Benzyl Cations Generated from N-Sulfamoylcarbamates

  摘要：

  [GRAPHICS]A new method for the generation of highly reactive benzyl cations by thermal decomposition of aryl-benzyl-sulfamoylcarbamates, obtained in a one-pot reaction from chlorosulfonyl isocyanate, is described. The generated cations alkylate aromatic compounds efficiently in the absence of catalysts.

  DOI：

  10.1021/ol0272489

文献信息

• Superacid BF₃–H₂O promoted benzylation of arenes with benzyl alcohols and acetates initiated by trace water
  作者：Shuting Zhang、Xiaohui Zhang、Xuege Ling、Chao He、Ruofeng Huang、Jing Pan、Jiaqiang Li、Yan Xiong

  DOI：10.1039/c4ra04059g

  日期：——

  An efficient in situ prepared superacid BF₃–H₂O promoted benzylation of arenes using benzyl alcohols and acetates achieves various diarylalkanes.

  一种高效的原位制备的超强酸BF3-H2O促进的芳烃苄基化反应，使用苄醇和醋酸酯制备各种二芳基烷烃。
• Uncatalyzed Friedel−Crafts Alkylation of Aromatic Compounds through Reactive Benzyl Cations Generated from <i>N</i>-Sulfamoylcarbamates
  作者：Michael Sefkow、Jens Buchs

  DOI：10.1021/ol0272489

  日期：2003.1.1

  [GRAPHICS]A new method for the generation of highly reactive benzyl cations by thermal decomposition of aryl-benzyl-sulfamoylcarbamates, obtained in a one-pot reaction from chlorosulfonyl isocyanate, is described. The generated cations alkylate aromatic compounds efficiently in the absence of catalysts.