乙基氨基氧基乙酸酯盐酸盐 | 3919-73-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙基氨基氧基乙酸酯盐酸盐
• 英文名称: ethyl aminooxyacetate hydrochloride
• 英文别名: O-Ethoxycarbonylmethylhydroxylamine hydrochloride；ethyl 2-aminooxyacetate;hydron;chloride
• CAS: 3919-73-1
• 化学式: C₄H₉NO₃*ClH
• 分子量: 155.581
• InChiKey: IKCYQNSSQXAQHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.14
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  61.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 乙基氨基氧基乙酸酯盐酸盐 以 乙醇 为溶剂， 反应 3.0h， 以87%的产率得到Ethyl 2-(methylideneamino)oxyacetate
  参考文献：
  名称：

  Design, Synthesis, and Biological Evaluation of Thio-Containing Compounds with Serum HDL-Cholesterol-Elevating Properties

  摘要：

  A novel series of substituted sulfanyldihydroimidazolones (1) that modulates high-density lipoprotein cholesterol (HDL-C) has been reported to have HDL-elevating properties in several animal models. Concerns about the chemical and metabolic stability of I directed us to explore the structure-activity relationship (SAR) of a related series of substituted thiohydantoins (2). Expansion of the scope of the thiohydantoin series led to exploration of compounds in related thio-containing ring systems 3-7 and the N-cyanoguanidine derivative 8. Compounds were tested sequentially in three animal models to assess their HDL-C elevating efficacy and safety profiles. Further evaluation of selected compounds in a dose-response paradigm culminated in the identification of compound 2.39 as a candidate compound for advanced preclinical. studies.

  DOI：

  10.1021/jm030219z
• 作为产物：
  描述：

  溴乙酸乙酯 以91%的产率得到乙基氨基氧基乙酸酯盐酸盐
  参考文献：
  名称：

  Symmetrical O-substituted dioximes of benzo-fused

  摘要：

  具有高抗癫痫和镇痛活性的药物由对称的β-二烷氧基亚胺环烯衍生物构成，其中亚胺双键与环双键或属于一个或多个融合苯环的双键共轭。它们对应于一般式I：##STR1##

  公开号：

  US04804684A1

文献信息

• Asymmetric Synthesis of Polyhydroxylated <i>N</i>-Alkoxypiperidines by Ring-Closing Double Reductive Amination: Facile Preparation of Isofagomine and Analogues
  作者：Gaëlle Malik、Xavier Guinchard、David Crich

  DOI：10.1021/ol203213f

  日期：2012.1.20

  A de novo synthesis of novel polyhydroxylated N-alkoxypiperidines based on the ring-closing double reductive amination of 1,5-dialdehydes, obtained by oxidative cleavage of cyclopentene derivatives, with O-substituted hydroxylamines is reported. Isofagomine was accessed by cleavage of the N–O bond of an N-alkoxypiperidine.

  报道了一种新的多羟基化的N-烷氧基哌啶的从头合成，该合成是基于通过用O-取代的羟胺对环戊烯衍生物进行氧化裂解而得到的1，5-二醛的双环还原胺化。通过切割N-烷氧基哌啶的N-O键可访问异黄花碱。
• Herbicidal 1,2,4-oxadiazin-5-one compositions
  申请人：Philagro

  公开号：US04154598A1

  公开（公告）日：1979-05-15

  Herbicidal and/or phyto-hormonal compositions containing 1,2,4-oxadiazin-5-one of the formula ##STR1## WHERE R represents H, alkyl or phenyl and Ar represents substituted phenyl or a 5 membered aromatic heterocyclic radical with O, S or N as the hetero-atom and optionally substituted are described.

  含有1,2,4-噁二唑-5-酮的除草剂和/或植物激素组合物的化学式为##STR1## 其中R代表H、烷基或苯基，Ar代表取代苯基或含有O、S或N作为杂原子的5元芳香杂环基团，并且可以选择性地进行取代。
• Some reactions of aminooxy acids
  作者：G. Zvilichovsky

  DOI：10.1016/s0040-4020(01)99441-4

  日期：1966.1

  dl-O-ureidohomoserine (α-amino-γ-ureido-oxybutyric acid), ureido-oxyacetic acid and their derivatives were synthesized by reaction of the corresponding amino-oxy acids with potassium cyanate. The reactions of amino-oxyacetic acid with arylisocyanates and phosgene were studied. The copper complex and cyclohexylammonium salt of amino-oxyacetic acid were isolated.

  通过使相应的氨基氧基酸与氰酸钾反应，合成了dl-O-脲基高丝氨酸（α-氨基-γ-脲基-氧丁酸），脲基-氧乙酸及其衍生物。研究了氨基氧乙酸与异氰酸芳基酯和光气的反应。分离出铜-络合物和氨基-氧乙酸的环己铵盐。
• Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04304770A1

  公开（公告）日：1981-12-08

  Preparation of pharmaceutical composition comprising, treatment of human and animal diseases with, and compound of, 3,7-disubstituted-3-cephem-4-carboxylic acid.

  含有3,7-二取代-3-头孢烯-4-羧酸的制药组合物的制备，以及用于治疗人类和动物疾病的化合物。
• NO Bond as a Glycosidic-Bond Surrogate: Synthetic Studies Toward Polyhydroxylated<i>N</i>-Alkoxypiperidines
  作者：Gaëlle Malik、Angélique Ferry、Xavier Guinchard、Thierry Cresteil、David Crich

  DOI：10.1002/chem.201202374

  日期：2013.2.4

  isofagomine, 3‐deoxyisofagomine, and numerous other N‐alkoxy analogues. The barrier to inversion in these polyhydroxylated N‐alkoxypiperidine derivatives was found by variable‐temperature NMR methods to be approximately 15 kcal mol−1. With the exception of N‐hydroxyisofagomine itself, none of the compounds prepared showed significant inhibitory activity against sweet almond β‐glucosidase.

  通过将高度官能化的1,5-二醛与各种羟胺进行双环双还原胺化（DRA），合成了一系列新型的多羟基N-烷氧基哌啶。所需的基于糖的二醛是由环戊二烯化钠分七步高效制备的。已经为DRA开发了两步协议。脱保护后，它导致了异黄酮，3-脱氧异氟谷氨酸和许多其他N-烷氧基类似物。通过变温NMR方法发现这些多羟基化的N-烷氧基哌啶衍生物的转化障碍约为15 kcal mol -1。除了N-hydroxyisofagomine本身，所制备的化合物均未显示出对甜杏仁β-葡萄糖苷酶的显着抑制活性。