ammonium hydrofluoride

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 卤代有机物
• 英文名称: ammonium hydrofluoride
• 英文别名: Ammonium hydrogen difluoride；ammonium hydrogendifluoride；ammonium hydrogen fluoride；ammonium hydrogenfluoride；Azanium;hydron;fluoride
• 化学式: 2F*H*H₄N
• 分子量: 57.0432
• InChiKey: LDDQLRUQCUTJBB-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.53
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ammonium hydrofluoride 在 盐酸 、 氨 作用下， 以 not given 为溶剂， 生成 三氯化铝
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Al: MVol.B1, 6.3.2.1, page 179 - 181

  摘要：

  DOI：

文献信息

• Hydroquinone derivatives useful in the production of vitamin E
  申请人：Hoffmann-La Roche Inc.

  公开号：US04689427A1

  公开（公告）日：1987-08-25

  The present invention is directed to novel hydroquinone derivatives which are useful as intermediates for the manufacture of (R,R,R)-.alpha.-tocopherol (natural vitamin E) as well as of racemic .alpha.-tocopherol. The invention is also directed to a process for the preparation of the hydroquinone derivatives of the invention.

  本发明涉及一种新颖的对苯二酚衍生物，可用作(R,R,R)-α-生育酚（天然维生素E）以及混合α-生育酚的制造中间体。该发明还涉及一种制备本发明的对苯二酚衍生物的方法。
• Process for the manufacture of optically active compounds
  申请人：Hoffmann-La Roche Inc.

  公开号：US04582919A1

  公开（公告）日：1986-04-15

  There is described a novel process for producing hydroquinone derivatives of the formula ##STR1## wherein R is an ether protecting group, and their conversion into d-.alpha.-tocopherol, starting from compounds of the formula ##STR2## wherein R is an ether protecting group and R.sup.1 is hydrogen or an ether protecting group.

  描述了一种新的生产羟基喹啉衍生物的过程，其化学式为##STR1##其中R为醚保护基，并将其转化为d-α-生育酚，起始于化合物的化学式##STR2##其中R为醚保护基，R.sup.1为氢或醚保护基。
• Hydrothermal Syntheses and Crystal Structure of NH4Ln3F10 (Ln=Dy, Ho, Y, Er, Tm)
  作者：Z.J. Kang、Y.X. Wang、F.T. You、J.H. Lin

  DOI：10.1006/jssc.2001.9131

  日期：2001.5

  earth fluorides NH4Ln3F10 (Ln=Dy, Ho, Y, Er, Tm) were synthesized by a hydrothermal method. Two polymorphs, of the hexagonal β-KYb3F10 and the cubic γ-KYb3F10 structure types, were formed under hydrothermal conditions for most of the rare earth fluorides except NH4Dy3F10, for which only the cubic γ-phase was obtained. The crystal structures of MLn3F10 (M=alkaline metal, NH+4 and Ln=rare earth) show

  通过水热法合成了稀土氟化铵NH 4 Ln 3 F 10（Ln = Dy，Ho，Y，Er，Tm）。在水热条件下，除了NH 4 Dy 3 F 10之外，大多数稀土氟化物都形成了六方β- KYb 3 F 10和立方γ- KYb 3 F 10结构类型的两种多晶型，其中只有立方γ获得了相。的晶体结构MLN 3 ˚F 10（中号=碱金属，NH+ 4和Ln =稀土）与离子半径之比（R M / R Ln）具有很强的相关性，这已在单价和稀土阳离子的离子半径的结构相图中表示。
• Method for removing the protecting group for hydroxy group
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US05260438A1

  公开（公告）日：1993-11-09

  A method for removing tri-substituted silyl group from .beta.-lactam compound having a tri-substituted silyl group-protecting hydroxy group, which comprises treating with an acid and a fluoride selected from alkali metal fluoride, alkaline earth metal fluoride and hydrogenfluoride of organic or inorganic amine, by which the tri-substituted silyl group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.

  一种从具有三取代硅基保护羟基的β-内酰胺化合物中去除三取代硅基的方法，包括使用酸和氟化物进行处理，所述氟化物选自有机或无机胺的碱金属氟化物、碱土金属氟化物和氢氟酸，通过该方法，可以在温和条件下轻松有效地去除三取代硅基，从而以低成本高收率地获得所需化合物。
• Process for preparing carbapenem derivatives
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US05359059A1

  公开（公告）日：1994-10-25

  Process for preparing carbapenem derivative of the formula [I], which comprises subjecting azetidinone compound of the formula [II] to intramolecular cyclization reaction together with elimination reaction of the group of --SR.sup.4, followed by re-adding said group of --SR.sup.4 to the 2-position of the carbapenem skeleton of the intramolecularly cyclized compound, which is industrially useful as process for preparing carbapenem antimicrobials or synthetic intermediate therefor. ##STR1## wherein R.sup.1 is protected or unprotected hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom or ester residue, R.sup.3 is hydrogen atom or lower alkyl group, and the group of --SR.sup.4 is group which can be used as substituent at 2-position of the carbapenem antimicrobials.

  制备公式[I]的碳青霉烯衍生物的过程包括将公式[II]的氮杂四元环化合物进行分子内环化反应和--SR.sup.4基团的消除反应，然后将--SR.sup.4基团重新加到分子内环化化合物的碳青霉烯骨架的2位上，该过程在工业上用于制备碳青霉烯抗微生物药物或其合成中间体。其中R.sup.1是保护或未保护的羟基取代的低碳基基团，R.sup.2是氢原子或酯基残基，R.sup.3是氢原子或低碳基基团，--SR.sup.4基团是可用作碳青霉烯抗微生物药物2位取代基团的基团。