2-(3,4-dimethylphenyl)-5-methyl-1,3,4-thiadiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,4-dimethylphenyl)-5-methyl-1,3,4-thiadiazole
• 化学式: C₁₁H₁₂N₂S
• 分子量: 204.296
• InChiKey: UCPDRBAXNXNYHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二甲基乙酰胺 、 在 potassium hydrogensulfate 作用下， 反应 5.0h， 以77%的产率得到2-(3,4-dimethylphenyl)-5-methyl-1,3,4-thiadiazole
  参考文献：
  名称：

  A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives

  摘要：

  An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO4 has been reported. This method reveals good reactivity and functional group tolerance, and a broad series of 1,3,4-thiadiazoles were obtained in moderate to good yields. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152195

文献信息

• New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
  申请人：Almirall, S.A.

  公开号：EP2322176A1

  公开（公告）日：2011-05-18

  This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), to pharmaceutical compositions comprising them, and to their use in therapy.

  这项发明涉及具有一般式(I)的新p38丝裂原活化蛋白激酶抑制剂，以及包含它们的药物组合物，以及它们在治疗中的应用。
• [EN] NEW 7-PHENYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE 7-PHÉNYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE
  申请人：ALMIRALL SA

  公开号：WO2011057757A1

  公开（公告）日：2011-05-19

  This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), to processes for their preparation, to pharmaceutical compositions comprising them, and to their use in therapy.

  这项发明涉及具有一般式(I)的新p38丝裂原活化蛋白激酶抑制剂，涉及它们的制备方法，包括它们的药物组合物，以及它们在治疗中的应用。
• A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives
  作者：Zongjie Gan、Binghua Tian、Jianyong Yuan、Dongzhi Ran、Lin Zhang、Gang Dong、Tao Pan、Yixin Zeng、Yu Yu

  DOI：10.1016/j.tetlet.2020.152195

  日期：2020.7

  An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO4 has been reported. This method reveals good reactivity and functional group tolerance, and a broad series of 1,3,4-thiadiazoles were obtained in moderate to good yields. (C) 2020 Elsevier Ltd. All rights reserved.