N-(2-mercaptoethyl)-2,2-dimethylpropionamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-mercaptoethyl)-2,2-dimethylpropionamide
• 英文别名: 2,2-dimethyl-N-(2-sulfanylethyl)propanamide
• 化学式: C₇H₁₅NOS
• 分子量: 161.268
• InChiKey: IZRBSTMRAPUWTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  30.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-mercaptoethyl)-2,2-dimethylpropionamide 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 生成 2-tert-Butyl-Δ²-thiazolin
  参考文献：
  名称：

  Total synthesis of (-)-mirabazole C

  摘要：

  The tetrathiazoline marine alkaloid (-)-mirabazole C (7) has been synthesized by cyclization of a diamide derivative of the tripeptide derived from (R)-2-methylcysteine.

  DOI：

  10.1021/jo00047a005
• 作为产物：
  描述：

  半胱胺盐酸盐 、 三甲基乙酰氯 在 ammonium chloride 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以81.8%的产率得到N-(2-mercaptoethyl)-2,2-dimethylpropionamide
  参考文献：
  名称：

  CORROSION PROTECTION COATINGS

  摘要：

  本发明涉及用于腐蚀控制的新涂层材料。

  公开号：

  US20100175583A1

文献信息

• Corrosion protection coatings
  申请人：Roschmann Konrad

  公开号：US08460445B2

  公开（公告）日：2013-06-11

  The present invention relates to new coating materials for corrosion control.

  本发明涉及用于腐蚀控制的新型涂层材料。
• Bismuth A3-Corroles: Useful Precursors for the Development of meso-Substituted Free-Base Corroles
  作者：Wolfgang Schoefberger、Felix Faschinger、Stefan Aichhorn、Markus Himmelsbach

  DOI：10.1055/s-0034-1379012

  日期：——

  Systematic studies on regioselective functionalization reactions employing oxygen-, nitrogen-, and sulfur-containing nucleophiles with bismuth A(3)-corroles under the influence of a strong non-nucleophilic base are reported. In the case of the thiols and dithiols a high-yielding reaction procedure was established to obtain mono-, di-, and tri-functionalized corroles at room temperature within short reaction times. The described method offers a possibility to attach bifunctional linker molecules to the para-position of the meso-pentafluorophenyl groups at positions 5, 10, and 15 of the corrole macrocycle. The described reaction strategy may serve as a versatile protocol for the covalent binding of corroles to proteins or antibodies and may be utilized to attach corroles on, for example, gold or titanium surfaces to study surface-supported reactions.
• KORROSIONSSCHUTZBESCHICHTUNGEN
  申请人：BASF SE

  公开号：EP2158276A1

  公开（公告）日：2010-03-03
• Antibody-Conjugated Double-Emulsion Nanocapsule and Preparation Methods Thereof
  申请人：National Chiao Tung University

  公开号：US20140356421A1

  公开（公告）日：2014-12-04

  An antibody-conjugated double-emulsion nanocapsule is provided. A linking group is introduced on the surface of a double-emulsion nanocapsule, which is composed of an oily shell enclosing an aqueous core, to link the double-emulsion nanocapsule with an antibody.
• AMIDE COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20180186782A1

  公开（公告）日：2018-07-05

  Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.