1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinyl-5-(ethoxyacetamido-methyl)pyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinyl-5-(ethoxyacetamido-methyl)pyrazole
• 英文别名: 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinyl-5-(N-methylethoxyacetamido)pyrazole；N-[5-cyano-2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazol-3-yl]-2-ethoxy-N-methylacetamide
• 化学式: C₁₇H₁₂Cl₂F₆N₄O₃S
• 分子量: 537.27
• InChiKey: JSWGRUUFKRUTRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  溴甲烷 、 potassium salt of 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinyl-5-(ethoxyacetamido)pyrazole 以 乙腈 为溶剂， 反应 6.0h， 以85%的产率得到1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinyl-5-(ethoxyacetamido-methyl)pyrazole
  参考文献：
  名称：

  Processes for the preparation of pesticidal compound

  摘要：

  制备杀虫化合物的过程，一种制备式(I)化合物的方法，其中：R1为CN或CSNH2；X为N或CR4；R2和R4分别为氢或氯；R3为卤素、卤代烷基、卤代氧烷或-SF5；R5和R6分别为烷基基团；n为0、1或2；该方法包括：(a)第一步，将式(II)的化合物与无机金属盐或有机碱反应，产生中间体化合物；(b)第二步，将中间体化合物与式(III)的烷基化试剂反应，其中R6为上述定义，Y为脱离基团。还声明了这些中间体化合物为新化合物。

  公开号：

  EP1223165A1

文献信息

• Processes for the preparation of pesticidal compounds and novel intermediates thereof
  申请人：Bayer Cropscience S.A.

  公开号：US06812347B2

  公开（公告）日：2004-11-02

  A process for the preparation of a compound of the formula (I): wherein R1 is CN or CSNH2; X is N or CR4; R2 and R4 are each independently hydrogen or chloro; R3 is halo, haloalkyl, haloalkoxy or —SF5; R5 and R6 are each independently alkyl and n is 0, 1 or 2; said process comprising reacting a compound of the formula (II): wherein the symbols are as defined above and W is H, with an alkylating agent of the formula (III): R6—Y  (III) wherein R6 is as defined above and Y is a leaving group. The process may also be conducted by reacting a compound of formula (II) initially with an inorganic salt or an organic base, and reacting the resultant salt of the compound of formula (II) with the alkylating agent.

  一种制备式（I）化合物的方法：其中R1为CN或CSNH2；X为N或CR4；R2和R4各自独立地为氢或氯；R3为卤代、卤代烷基、卤代烷氧基或—SF5；R5和R6各自独立地为烷基，n为0、1或2；所述方法包括将式（II）化合物与式（III）烷基化试剂反应：其中符号如上所定义，W为H，R6为如上所定义，Y为离去基团。该方法也可以通过最初将式（II）化合物与无机盐或有机碱反应，然后将式（II）化合物的盐与烷基化试剂反应来进行。
• NON-ANIMAL PRODUCT CONTAINING VETERINARY FORMULATIONS
  申请人：Merial, Inc.

  公开号：EP1539116B1

  公开（公告）日：2016-02-17
• Long acting injectable formulations
  申请人：Soll D. Mark

  公开号：US20070042013A1

  公开（公告）日：2007-02-22

  The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.
• Topical Formulations Comprising 1-N-Arylpyrazole Derivatives and Amitraz
  申请人：Boeckh Albert

  公开号：US20090192207A1

  公开（公告）日：2009-07-30

  The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.
• TOPICAL FORMULATIONS COMPRISING 1-N-ARYLPYRAZOLE DERIVATIVES AND AMITRAZ
  申请人：BOECKH Albert

  公开号：US20130023490A1

  公开（公告）日：2013-01-24

  The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.