orniplabin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: orniplabin
• 英文别名: (2S)-2,5-bis[(2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]pentanoic acid
• 化学式: C₅₁H₆₈N₂O₁₀
• 分子量: 869.108
• InChiKey: CRNDCHORWGDFGR-DFQXUFOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  63
• 可旋转键数：
  18
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  177
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  soybean powder 、 鸟氨酸 、 meat extract 、 peptone 、 yeast extract 生成 orniplabin
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF NEPHRITIS AND METHOD FOR PRODUCING SAME
  申请人：National University Corporation Tokyo University of Agriculture and Technology

  公开号：EP1944027A1

  公开（公告）日：2008-07-16

  A pharmaceutical composition for treatment of nephritis of the present invention comprises a triprenylphenol compound as an active substance, preferably the triprenylphenol compound represented by the following general formula (1) as an active substance, and further preferably orniplabin represented as n=3 in the following general formula (1) as an active substance. general formula (1) (in formula (1) n is one of integer selected from 1 to 10). Further a manufacturing method of a pharmaceutical composition for treatment or prevention of nephritis of the present invention comprises using a triprenylphenol compound as an active substance.

  本发明的一种治疗肾炎的药物组合物包括作为活性物质的三烯丙基酚化合物，优选如下通式(1)所代表的三烯丙基酚化合物作为活性物质，进一步优选如下通式(1)中n=3所代表的orniplabin作为活性物质。 通式(1) (在式(1)中，n 是选自 1 至 10 的整数之一)。 本发明治疗或预防肾炎的药物组合物的进一步制造方法包括使用三烯丙基酚化合物作 为活性物质。
• PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF NEPHRITIS AND MANUFACTURING METHOD THEREOF
  申请人：Hasumi Keiji

  公开号：US20090270476A1

  公开（公告）日：2009-10-29

  A pharmaceutical composition for treatment of nephritis of the present invention comprises a triprenylphenol compound as an active substance, preferably the triprenylphenol compound represented by the following general formula (1) as an active substance, and further preferably orniplabin represented as n=3 in the following general formula (1) as an active substance. general formula (1) (in formula (1) n is one of integer selected from 1 to 10). Further a manufacturing method of a pharmaceutical composition for treatment or prevention of nephritis of the present invention comprises using a triprenylphenol compound as an active substance.