乙酰氧基乙酸丁酯 | 85237-83-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙酰氧基乙酸丁酯
• 英文名称: Butyl acetoxyacetate
• 英文别名: butyl 2-acetyloxyacetate
• CAS: 85237-83-8
• 化学式: C₈H₁₄O₄
• 分子量: 174.19
• InChiKey: GOSQVHOQDBHYGQ-UHFFFAOYSA-N

物化性质

• 沸点：
  221.1±13.0 °C(Predicted)
• 密度：
  1.039±0.06 g/cm3(Predicted)
• LogP：
  1.871 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT
  申请人：MARUYAMA Toru

  公开号：US20100010222A1

  公开（公告）日：2010-01-14

  A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP 4 agonist as an active ingredient. An EP 4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

  一种用于局部治疗预防和/或治疗与骨量减少相关疾病的药物组合物，包括EP4激动剂作为活性成分。EP4激动剂，其中包括具有前列腺素骨架的化合物作为代表，具有促进骨形成的作用，因此对于预防和/或治疗与骨量减少相关的疾病（如原发性骨质疏松症、继发性骨质疏松症、骨癌转移、高钙血症、帕吉特病、骨丢失和骨坏死、术后骨生成、骨移植替代疗法）非常有用。
• Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as active ingredient
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：EP2255829A2

  公开（公告）日：2010-12-01

  A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

  一种局部用药的药物组合物，用于预防和/或治疗与骨量减少有关的疾病，其活性成分包括一种 EP4 激动剂。EP4激动剂（其中包括以前列腺素骨架为代表的化合物）具有促进骨形成的作用，因此可用于预防和/或治疗与骨量减少有关的疾病（骨病，如原发性骨质疏松症、继发性骨质疏松症、癌症骨转移、高钙血症、Paget病、骨丢失和骨坏死、术后成骨、植骨替代疗法）。
• METHOD FOR PRODUCING ACETIC ACID
  申请人：Daicel Corporation

  公开号：EP3398930A1

  公开（公告）日：2018-11-07

  It is intended to provide a method capable of industrially and efficiently producing acetic acid having a good potassium permanganate test value without a large cost. The method includes a step of distilling an aqueous phase and/or an organic phase of a column top condensate of a lower boiling point component removal column by a crotonaldehyde removal column; and the reflux ratio of the lower boiling point component removal column is not less than 2 (when the aqueous phase is refluxed), and the crotonaldehyde removal column is operated such that at least one of the following conditions (i) to (iii) is satisfied: (i) the reflux ratio of the distillation column is not less than 0.01; (ii) the ratio of the crotonaldehyde concentration (ppm by mass) in a distillate liquid of the distillation column to the crotonaldehyde concentration (ppm by mass) in a charging mixture (former/latter) is less than 1; and (iii) the ratio of the crotonaldehyde concentration (ppm by mass) in a bottom fraction of the distillation column to the crotonaldehyde concentration (ppm by mass) in a charging mixture (former/latter) is more than 1.

  本发明旨在提供一种能够工业化高效生产醋酸的方法，该醋酸具有良好的高锰酸钾测试值，且成本低廉。 该方法包括一个步骤，即用巴豆醛去除塔蒸馏低沸点组分去除塔的塔顶冷凝物中的水相和/或有机相；低沸点组分去除塔的回流比不小于 2（当水相回流时），巴豆醛去除塔的操作要满足以下条件(i)至(iii)中的至少一个： (i) 蒸馏塔的回流比不小于 0.01； (ii) 蒸馏塔馏出液中巴豆醛浓度（ppm 质量分数）与加料混合物（前者/后者） 中巴豆醛浓度（ppm 质量分数）之比小于 1；以及 (iii) 蒸馏塔底部馏分中的巴豆醛浓度（ppm 质量分数）与加料混合物 （前者/后者）中的巴豆醛浓度（ppm 质量分数）之比大于 1。
• ACETIC ACID PRODUCTION METHOD
  申请人：Daicel Corporation

  公开号：EP3599231A1

  公开（公告）日：2020-01-29

  Provided is a method for industrially efficiently producing acetic acid that yields a good potassium permanganate test result, without enormous cost. A light ends column (first distillation column) is operated with a reflux ratio at a specific level or more, a distillation column (crotonaldehyde-removing column) is provided for treating an organic phase of an overhead condensate from the light ends column, and the crotonaldehyde-removing column is operated under such conditions as to meet at least one of conditions (i) to (iii) as follows: (i) a reflux ratio at the distillation column is 0.01 or more; (ii) at the distillation column, the ratio of a crotonaldehyde concentration in a distillate to a crotonaldehyde concentration in a charge liquid is less than 1; and (iii) at the distillation column, the ratio of a crotonaldehyde concentration in bottoms to a crotonaldehyde concentration in the charge liquid is greater than 1. The crotonaldehyde concentration in an acetic acid stream (first acetic acid stream) resulting from light ends removal in the light ends column is controlled at a specific level or less, and/or the reflux ratio at a dehydration column (second distillation column) is controlled at a specific level or more, and at least one of the ratios CCR/CECR and CCR/CBA in at least one of the first acetic acid stream and an acetic acid-rich stream resulting from further purification of the first acetic acid stream is lowered, to give an acetic acid product that yields a better potassium permanganate test result.

  本发明提供了一种工业化高效生产醋酸的方法，该方法可获得良好的高锰酸钾测试结果，且成本低廉。一个轻端塔（第一蒸馏塔）在回流比为特定水平或更高的条件下运行，一个蒸馏塔（巴豆醛去除塔）用于处理来自轻端塔的高架冷凝物的有机相，巴豆醛去除塔在满足以下条件（i）至（iii）中至少一个条件的条件下运行：(i) 蒸馏塔的回流比为 0.01 或以上；(ii) 蒸馏塔的馏分中巴豆醛浓度与补给液中巴豆醛浓度之比小于 1；(iii) 蒸馏塔的塔底中巴豆醛浓度与补给液中巴豆醛浓度之比大于 1。在轻质末端塔中去除轻质末端产生的乙酸流（第一乙酸流）中的巴豆醛浓度控制在特定水平或更低，和/或脱水塔（第二蒸馏塔）的回流比控制在特定水平或更高、降低第一醋酸流和经第一醋酸流进一步纯化后产生的富醋酸流中至少一种醋酸流的 CCR/CECR 和 CCR/CBA 比率，以得到高锰酸钾测试结果更好的醋酸产品。
• JP2004315789A
  申请人：——

  公开号：JP2004315789A

  公开（公告）日：2004-11-11