NPI-2065

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: NPI-2065
• 英文别名: (-)-salinosporamide A；salinosporamide F；(1R,4S,5S)-4-(2-chloroethyl)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• 化学式: C₁₅H₂₀ClNO₄
• 分子量: 313.781
• InChiKey: NGWSFRIPKNWYAO-XWKQNIGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 ammonium cerium (IV) nitrate 作用下， 以 甲醇 、 水 为溶剂， 以90%的产率得到NPI-2065
  参考文献：
  名称：

  A1,3-strain enabled retention of chirality during bis-cyclization of β-ketoamides: total synthesis of (−)-salinosporamide A and (−)-homosalinosporamide A

  摘要：

  本文介绍了一种简明的对映体选择性合成 I 期抗癌剂 (â)-salinosporamide A 的方法。所描述策略的简洁性源于δ-酮三级酰胺的关键双环化，这种双环化是在克级规模上完成的，通过A1,3-应变保持了光学纯度，使得外延化相对于双环化的速度较慢。(â)-homosalinosporamide A 的合成证明了该策略在衍生物合成方面的多功能性。

  DOI：

  10.1039/c0cc00607f

文献信息

• [3.2.0] Heterocyclic compounds and methods of using the same
  申请人：Potts Christine Barbara

  公开号：US20050288352A1

  公开（公告）日：2005-12-29

  Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

  本发明涉及具有抗癌，抗炎和抗微生物特性的I-VI式化合物及其衍生物和类似物，以及包括其中一种或多种化合物及其衍生物或类似物的组合物。还公开了包含这些化合物的药物组合物以及使用公开的化合物或药物组合物治疗癌症，炎症和微生物感染的方法。
• Salt formulations for the fermentation of marine microorganisms
  申请人：Triphase Research and Development I Corp.

  公开号：US10011814B2

  公开（公告）日：2018-07-03

  Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.

  公开了用于海洋微生物发酵的生长培养基。培养基包括特定浓度的钾、钙、锶、硼酸盐和氟化物。另外，生长培养基还包括特定浓度的钴或特定浓度的维生素 B12。还公开了通过海洋微生物发酵生产某些所需化合物的方法。
• Methods of using [3.2.0] heterocyclic compounds and analogs thereof
  申请人：Palladino Michael

  公开号：US20070004676A1

  公开（公告）日：2007-01-04

  Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.
• [3.2.0] HETEROCYCLIC COMPOUNDS AND METHODS OF USING THE SAME
  申请人：Potts Christine Barbara

  公开号：US20080070969A1

  公开（公告）日：2008-03-20

  Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.
• SALT FORMULATIONS FOR THE FERMENTATION OF MARINE MICROORGANISMS
  申请人：Lam Kin Sing

  公开号：US20080160590A1

  公开（公告）日：2008-07-03

  Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B 12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.