D-erythro-3,6-Dideoxy-2-hexulosonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: D-erythro-3,6-Dideoxy-2-hexulosonate
• 英文别名: 1,4,5-Trihydroxyhexan-2-one
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: JBFPUJIRZOCCCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-hydroxypropanal 、 sodium pyruvate 在 2-dehydro-3-deoxy-phosphogluconate aldolase potassium phosphate 作用下， 以 水 为溶剂， 反应 48.0h， 以380 mg的产率得到D-erythro-3,6-Dideoxy-2-hexulosonate
  参考文献：
  名称：

  Pyruvate aldolases as reagents for stereospecific aldol condensation

  摘要：

  KDPG aldolase, a representative member of the largest but as of yet unexplored group of aldolases which utilize pyruvate as the nucleophilic component in aldol condensation, accepts a number of unnatural aldehydes as electrophiles in stereospecific aldol condensation, providing access to highly and differentially functionalized alpha-keto acid products.

  DOI：

  10.1021/jo00028a005

文献信息

• Pyruvate aldolases as reagents for stereospecific aldol condensation
  作者：Sarah T. Allen、Geoffrey R. Heintzelman、Eric J. Toone

  DOI：10.1021/jo00028a005

  日期：1992.1

  KDPG aldolase, a representative member of the largest but as of yet unexplored group of aldolases which utilize pyruvate as the nucleophilic component in aldol condensation, accepts a number of unnatural aldehydes as electrophiles in stereospecific aldol condensation, providing access to highly and differentially functionalized alpha-keto acid products.