N-[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
• 英文别名: N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester；(3S)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[2-[(1-methoxy-1-oxopropan-2-yl)amino]phenyl]-4-oxobutanoic acid
• 化学式: C₂₄H₃₀N₂O₇
• 分子量: 458.511
• InChiKey: FWPUNSOSZYYRBA-FUBQLUNQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester 以 甲醇 、 水 、 乙酸乙酯 为溶剂， 以93%的产率得到高倍甜味剂标准品
  参考文献：
  名称：

  Crystals of aspartame derivative

  摘要：

  N-[N-[3-(3-羟基-4-甲氧基苯基)丙基]-L-α-天冬氨酸]-L-苯丙氨酸1-甲酯是一种具有高甜度的甜味剂，以结晶形式提供，具有高稳定性和良好纯度，适合作为商业产品。

  公开号：

  US20030009050A1
• 作为产物：
  描述：

  高倍甜味剂标准品 以 甲醇 、 醋酸异丙酯 为溶剂， 生成 N-[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
  参考文献：
  名称：

  Crystals of aspartame derivative

  摘要：

  N-[N-[3-(3-羟基-4-甲氧基苯基)丙基]-L-α-天冬氨酸]-L-苯丙氨酸1-甲酯是一种具有高甜度的甜味剂，以结晶形式提供，具有高稳定性和良好纯度，适合作为商业产品。

  公开号：

  US20030009050A1

文献信息

• Process for producing cinnamaldehyde derivatives, use thereof and the like
  申请人：AJINOMOTO CO., INC.

  公开号：US20030163004A1

  公开（公告）日：2003-08-28

  A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl) propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl) propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.

  一种方便高效地生产高纯度肉桂醛衍生物的方法，例如(2E)-(3-羟基-4-甲氧基)肉桂醛，包括在碱的存在下，通过将苯甲醛衍生物（如异香草醛等）与乙醛反应，特别是最好是在低温下逐渐滴加乙醛至其中的水溶液中进行反应。因此获得的肉桂醛衍生物被选择性还原以产生3-(3-羟基-4-取代(甲氧基基团等)苯基)丙醛。此外，通过将所述化合物与阿斯巴甜进行还原烷基化反应，可以工业上高效地生产1-甲基酯，它是一种具有高甜味强度的甜味剂。同时也提供了相应的工艺流程。
• High-Potency Sweetener Composition With Phytoestrogen and Compositions Sweetened Therewith
  申请人：Prakash Indra

  公开号：US20080107776A1

  公开（公告）日：2008-05-08

  The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic, high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic, high-potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as phytoestrogens. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.

  本发明涉及一般性的功能性甜味剂组合物，包括非卡路里或低卡路里的天然和/或合成高效甜味剂，以及制备和使用它们的方法。特别地，本发明涉及不同的功能性甜味剂组合物，包括至少一个非卡路里或低卡路里的天然和/或合成高效甜味剂、至少一个甜味改善组合物和至少一个功能性成分，例如植物雌激素。本发明还涉及功能性甜味剂组合物和方法，可以通过赋予更类似于糖的味道或特性来改善非卡路里或低卡路里高效甜味剂的口感。特别地，功能性甜味剂组合物和方法提供更类似于糖的时间特征，包括甜味的开始和持续时间，以及/或更类似于糖的风味特征。
• TISSUE DEGENERATION PROTECTION
  申请人：Geuns Joannes

  公开号：US20100099640A1

  公开（公告）日：2010-04-22

  The present invention provides isolated or essentially pure diterpenoic tetrahydropyran, such as steviol-19-glucuronide, steviol, stevioside and rebaudioside processes for obtaining the same and methods for obtaining stable pharmaceutically acceptable salts of the same for use of such compounds or compositions in a treatment of cardiovascular disorders or vascular disease or for the manufacture of medicaments to treat a condition of a cardiovascular disorder or vascular disease.

  本发明提供了分离或基本纯的二萜四氢吡喃类化合物，例如甜菊糖苷-19-葡萄糖醛酸酯，甜菊糖，甜菊糖苷和葛根糖苷，以及获得它们的方法和获得这些化合物的稳定的药学上可接受的盐的方法，用于治疗心血管疾病或血管疾病或用于制造治疗心血管疾病或血管疾病症状的药物。
• Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof
  申请人：Nagashima Kazutaka

  公开号：US20050175755A1

  公开（公告）日：2005-08-11

  The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.

  本发明涉及一种制造天冬氨酸二肽酯化合物的方法，可用作甜味剂，以及可用于制造过程中的醛。
• High-Potency Sweetener Composition with Glucosamine and Compositions Sweetened Therewith
  申请人：Prakash Indra

  公开号：US20070116827A1

  公开（公告）日：2007-05-24

  The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and/or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as glucosamine. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile.

  本发明涉及一般性的功能性甜味剂组合物，包括无热量或低热量的天然和/或合成高强度甜味剂以及制备和使用它们的方法。特别地，本发明涉及不同的功能性甜味剂组合物，包括至少一种无热量或低热量的天然和/或合成高强度甜味剂，至少一种增甜剂组合物和至少一种功能性成分，如葡萄糖胺。本发明还涉及功能性甜味剂组合物和方法，可以通过赋予更像糖的味道或特性来改善无热量或低热量高强度甜味剂的味道。特别地，功能性甜味剂组合物和方法提供更像糖的时间特性，包括甜味的开始和持续时间，和/或更像糖的口味特性。