amino penicillanic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: amino penicillanic acid
• 英文别名: aminopenicillanic acid；(2S,5R)-2-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 化学式: C₈H₁₂N₂O₃S
• 分子量: 216.261
• InChiKey: LTEPSSCJOSLAMO-XRGYYRRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  amino penicillanic acid 、 O-[D(-)-α-(3-cyclohexylcarbonyl-3-methylureido)-phenylacetyl]-C-cyano-C-ethoxy-carbonyl-formaldehydeoxime 、 6-aminopenicillanic acid 生成 青霉素
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Method for Treating Surfaces with Copolymers
  申请人：Bouloussa Othman

  公开号：US20080226585A1

  公开（公告）日：2008-09-18

  The present invention relates to a method for treating at least a surface of a substrate containing labile hydrogen atoms to confer to it cytotoxic properties or cell-adhesion properties, characterized in that it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof.

  本发明涉及一种处理含有不稳定氢原子的衬底表面的方法，以赋予其细胞毒性或细胞粘附性能。其特征在于，该方法包括至少一步，其中在液体介质中暴露该衬底或其表面至少一种共聚物，该共聚物包含至少一种A型单体单元，包括至少一种反应位点，能够通过共价键连接到该衬底或该表面，以及至少一种B型单体单元，包括至少一种分子，能够赋予该衬底或该表面抗微生物、抗病毒和/或抗真菌性能或细胞粘附性能，该步骤在有效条件下进行，以促进该共聚物与该衬底或其表面的共价嫁接。
• Method for Making Ionomers Using Amine Compounds Comprising Salt Functional Groups, Ionomers made by the Method and Sports Equipment Comprising Such Ionomers
  申请人：Kim J. Hyun

  公开号：US20070232756A1

  公开（公告）日：2007-10-04

  Ionomeric reaction products are disclosed that are made by combining a monomer, oligomer or polymer having at least one reactive carboxyl group and/or isocyanate group, or functional group or groups equivalent thereto or derived therefrom, with an amine compound having both an amine and an anionic functional group and a formula [RHN—(R 1 ) m —(X − ) n ] o -M a+ p where R is hydrogen, aliphatic, alicyclic, arylaliphatic or aromatic, R 1 is a linking group that links the amine and salt functional groups and is aliphatic, alicyclic, arylaliphatic or aromatic, X is an anionic group, M is a positively charged species, a is 1-4, m is 0 or greater, n is 1-4, o is 1-4 and p is 0-4, more typically 1-4. An amount of the amine compound is used to react with at least a portion of the reactive functional groups. A method for making a golf ball also is disclosed, as are golf balls comprising disclosed ionomers. At least one component of a golf ball, such as a cover layer, is made comprising disclosed ionomers. The golf ball can have any construction suitable for a golf ball, including multi-layered balls, such as a 3- or 4-piece ball.

  本发明公开了离子聚合物反应产物，其通过将至少具有一个反应性羧基和/或异氰酸酯基或等效的功能基团或由其衍生的单体、低聚物或聚合物与一种同时具有胺基和阴离子功能基团的胺化合物结合而制成，其具有以下化学式[RHN—(R1)m—(X−)n]o-Ma+p，其中R为氢、脂肪、脂环、芳基脂肪或芳香族，R1是连接胺基和盐基团的连接基团，为脂肪、脂环、芳基脂肪或芳香族，X为阴离子基团，M为正电荷物种，a为1-4，m为0或更大，n为1-4，o为1-4，p为0-4，更通常为1-4。使用一定量的胺化合物来与至少部分反应性功能基团反应。本发明还公开了一种制造高尔夫球的方法，以及包括所述离子聚合物的高尔夫球。高尔夫球的至少一个组件，如覆盖层，是由所述离子聚合物制成的。高尔夫球可以具有适合高尔夫球的任何结构，包括多层球，如3或4层球。
• COMPOSITIONS COMPRISING AN AMINO TRIAZINE AND IONOMER OR IONOMER PRECURSOR
  申请人：Kim Hyun J.

  公开号：US20090270201A1

  公开（公告）日：2009-10-29

  Disclosed embodiments concern using at least one triazine, typically an amine or polyamine triazine (referred to as amino triazines), in combination with at least one ionomer or ionomer precursor to form compositions useful for making sporting equipment, such as golf ball components. The ionomer or ionomer precursor typically includes plural acid functional groups, such as carboxyl or carboxylate groups, that react or form salts with the amino triazine. Specific examples, without limitation, of suitable amino triazines include guanamine, 6-methyl-1,3,5-triazine-2,4-diamine (acetoguanamine), 6-nonyl-1,3,5-triazine-2,4-diamine (nonylguanamine), 6-phenyl-1,3,5-triazine-2,4-diamine (benzoguanamine) and 2,4,6-triamino-triazine (melamine).

  公开的实施例涉及使用至少一种三嗪，通常是胺或多胺三嗪（称为氨基三嗪），与至少一种离子聚合物或离子聚合物前体结合，形成用于制造运动器材（例如高尔夫球组件）的组合物。离子聚合物或离子聚合物前体通常包括复数酸性官能团，例如羧基或羧酸盐基团，与氨基三嗪反应或形成盐。适当的氨基三嗪的具体示例包括脲胍、6-甲基-1,3,5-三嗪-2,4-二胺（乙酰胍）、6-壬基-1,3,5-三嗪-2,4-二胺（壬基胍）、6-苯基-1,3,5-三嗪-2,4-二胺（苯基胍）和2,4,6-三氨基-三嗪（三聚氰胺）。
• Novel penicillanic acid derivatives
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0148283A1

  公开（公告）日：1985-07-17

  @ 6-Amidinopenicillanic acid derivatives wherein one of the nitrogen atoms of the amidino group is part of a heterocyclic ring having on a side chain an unsubstituted heterocyclic ring containing 2 to 3 nitrogen atoms, with formula: wherein n is 0 or 1; is a saturated 5 to 7 membered heterocyclic ring containing the nitrogen atom as the only heteroatom, said ring being unsubstituted or substituted in one or more positions with lower alkyl; is a 5 to 7 membered heterocyclic ring having at most one additional nitrogen atom, from 0 to 2 additional double bonds, and, aside from R, either being unsubstituted or substituted in one or more positions with lower alkyl; R is lower alkyl, nitro, hydrogen,-COOH,-(CH2)y-NHR4;-(CH2)y-OR3 and R3 is hydrogen or lower alkyl, y is an integer from 0 to 4; R, is hydrogen, lower alkyl or an amino-protecting group, (Continuation next page) R5 and R6 are hydrogen or lower alkyl and R7 is lower alkylene, hydrolyzable esters thereof, salts thereof and hydrates thereof, and with formula: wherein n is an integer from 0 to 1; R, is hydrogen or lower alkyl; is a saturated 5 to 7 membered heterocyclic ring containing the nitrogen atom as the only heteroatom, said ring being unsubstituted or substituted in one or more positions with lower alkyl; is a 5 to 7 membered heterocyclic ring containing no additional double bonds or can be additionally aromatic when it is 5 membered, said ring being either unsubstituted or substituted in one or more positions with lower alkyl; and R7 is lower alkylene, hydrolyzable esters thereof, salts thereof and hydrates thereof. These compounds are useful as antibiotics.

  @ 6-脒基青霉烷酸衍生物，其中脒基的一个氮原子是一个杂环的一部分，该杂环的侧链上有一个包含 2 至 3 个氮原子的未取代杂环，其式为 其中 n 为 0 或 1； 是含有氮原子作为唯一杂原子的 5 至 7 个成员的饱和杂环，所述环未经取代或在一个或多个位置被低级烷基取代； R是低级烷基、硝基、氢、-COOH、-(CH2)y-NHR4;-( )y-OR3 和-( )y-OR4。 R3 是氢或低级烷基，y 是 0 至 4 的整数；R, 是氢、低级烷基或氨基保护基团， （下页接下页） R5 和 R6 是氢或低级烷基，R7 是低级亚烷基，其可水解酯、其盐和其水合物，并具有 式： 其中 n 是 0 至 1 的整数；R, 是氢或低级烷基； 是含有氮原子作为唯一杂原子的 5 至 7 个成员的饱和杂环，所述环未被取代或在一个或多个位置被低级烷基取代； R7 是低级亚烷基、其可水解酯、其盐类和其水合物。 这些化合物可用作抗生素。
• Optically active, ethylenically unsaturated monomers and polymers thereof
  申请人：M & D RESEARCH CO., LTD.

  公开号：EP0281234A1

  公开（公告）日：1988-09-07

  Disclosed are an optically active, ethylenically unsaturated monomer represented by the following structural formula: wherein: A stands for S, SO or SO₂; X and Y each stand for a hydrogen atom or a substituent selected from the group consisting of alkyl groups and acyl groups; Z stands for a substituent selected from the group consisting of alkoxy, alkylamino, hydroxyl and silyloxy groups; and X and Y can be bonded together to form a ring with the nitrogen atom to which they are bonded or X and Y can be a single group bonded to said nitrogen atom through a double bond, with the proviso that at least one of X and Z is an alkenyl equivalent to said group, and polymers of this monomer. One typical instance of the monomer is benzyl 6-acrylaminopenicillanate.

  公开了一种光学活性乙烯基不饱和单体，其结构式如下： 其中A代表S、SO或SO₂；X和Y各自代表一个氢原子或一个选自烷基和酰基的取代基；Z代表一个选自烷氧基、烷基氨基、羟基和硅氧基的取代基；X 和 Y 可以键合在一起，与所键合的氮原子形成一个环，或者 X 和 Y 可以是单个基团，通过双键与所述氮原子键合，但条件是 X 和 Z 中至少有一个是与所述基团相当的烯基、 以及这种单体的聚合物。这种单体的一个典型例子是 6-丙烯酰胺青霉烷酸苄酯。