methacrylic acid dimethylaminoethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methacrylic acid dimethylaminoethyl ester
• 英文别名: dimethylaminoethyl methylacrylate；(N,N-dimethylamino)ethyl methacrylate；dimethylamino-ethyl methacrylate；n-Dimethylaminoethyl methacrylate；1-(dimethylamino)ethyl 2-methylprop-2-enoate
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: HMLSBRLVTDLLOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methacrylic acid dimethylaminoethyl ester 、 hexapropylphosphoric triamide 、 4-甲氧基苯酚 、 丙烯酸乙酯 生成 N,N-dimethylaminoethyl 2-methyl-4-carbethoxy-4-pentenoate
  参考文献：
  名称：

  Esters of 4-substituted 2-methyleneglutaric acids and method for

  摘要：

  通过将丙烯酸酯与α-取代丙烯酸酯（例如甲基丙烯酸酯）在三级有机膦、有机磷三胺、有机膦酸二胺或有机膦酸胺的存在下反应，制备4-取代2-亚甲基戊二酸酯。

  公开号：

  US04145559A1
• 作为产物：
  描述：

  无水二甲氨基乙醇 生成 methacrylic acid dimethylaminoethyl ester
  参考文献：
  名称：

  Process for producing dimethylaminoethyl methacrylate

  摘要：

  甲基丙烯酸甲酯与二甲基氨基乙醇经过醇酯交换反应，使用有机锡化合物作为催化剂。通常使用的有机锡化合物包括四丁基锡、三辛基锡乙醇酸酯、二丁基二甲氧基锡、二丁基二氢氧化锡、二丁基硬脂酸锡、二丁基马来酸锡、双(三丁基锡)氧化物和双(二丁基甲氧基锡)氧化物。

  公开号：

  US04281175A1

文献信息

• [EN] PHENOTHIAZINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE ET LEURS UTILISATIONS
  申请人：CAMP4 THERAPEUTICS CORP

  公开号：WO2019195789A1

  公开（公告）日：2019-10-10

  The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).

  本发明提供了吩噻嗪化合物，其制备方法，包含该化合物的药物组合物，以及在治疗各种疾病或症状中使用该化合物或组合物，例如核糖体紊乱和核糖体病，例如钻石-布莱克范贫血（DBA）。
• Enol ethers
  申请人：Eastman Chemical Company

  公开号：US10889536B1

  公开（公告）日：2021-01-12

  Disclosed are enol ethers compounds. The enol ethers exhibit low volatile organic content and are useful in a variety of chemical applications. The enol ethers can be used in applications as diluents, wetting agents, coalescing aids, paint additives and as intermediates in chemical processes. The enol ethers also have particular utility as film-hardening additives in coating formulations.

  披露了烯醇醚化合物。这些烯醇醚具有低挥发性有机成分，并且在各种化学应用中很有用。这些烯醇醚可以用作稀释剂、润湿剂、凝聚助剂、涂料添加剂以及化学过程中的中间体。这些烯醇醚在涂料配方中还具有特殊的用途，可作为硬化膜添加剂。
• [EN] RANDOM COPOLYMER THERAPEUTIC AGENT CARRIERS AND ASSEMBLIES THEREOF<br/>[FR] SUPPORTS POUR AGENTS THÉRAPEUTIQUES À BASE D'UN COPOLYMÈRE ALÉATOIRE ET ENSEMBLES À BASE DE CEUX-CI
  申请人：UNIV WASHINGTON CT COMMERCIALI

  公开号：WO2015073579A1

  公开（公告）日：2015-05-21

  Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.

  本文提供的是包括包围核心的壳体的粒子组装体。壳体包括一种粒子稳定的随机共聚物。核心包括一种核心随机共聚物。这些粒子组装体具有仿生设计，其中包含离散化学和生物功能的聚合物组分被设计成自发自组装成粒子。本文还提供了具有共轭治疗剂的随机共聚物，这些治疗剂可以被酶或水从共聚物中裂解。
• PREPARATION OF FUNCTIONALIZED ALKOXYAMINE INITIATOR AND ITS USE
  申请人：——

  公开号：US20030236368A1

  公开（公告）日：2003-12-25

  A one-pot process for the preparation of functional alkoxyamines of the general formula (I), 1 is disclosed. The process entails (1) reacting an oxidizing agent with a sterically hindered secondary amine to produce an aqueous phase and a nitroxyl radical (2) removing the aqueous phase and adding to the nitroxyl radical one or more vinyl monomer(s) conforming to a formula and a system which produces free radicals. Also disclosed is a process of polymerizing monomers using the functional alkoxyamine.

  披露了一种用于制备具有一般公式（I）的功能性烷氧基胺的一锅法工艺。该工艺包括：（1）使用氧化剂与空间位阻较大的二级胺反应，产生水相和硝基氧自由基；（2）移除水相，并向硝基氧自由基中加入一种或多种符合公式的乙烯基单体以及能够产生自由基的体系。还披露了一种使用功能性烷氧基胺聚合单体的工艺。
• Copolymers Based on N-Vinylpyrrolidone and Branched Aliphatic Carbonxylic Acids, and Their Use as Solubilizers
  申请人：Angel Maximilian

  公开号：US20080200564A1

  公开（公告）日：2008-08-21

  Copolymers comprising: (a) 60 to 99% by weight of at least one monomer selected from the group consisting of N-vinyllactams, N-vinylamides, and mixtures thereof; (1) 1 to 40% by weight of at least one monomer selected from the group consisting of vinyl esters of aliphatic branched C 8 -C 30 -carboxylic acids; (c) 0 to 30% by weight of vinyl acetate; and (d) 0 to 39% by weight of at least one additional free-radically copolymnerizable monomer; wherein the % by weight content of components (a), (b), (c) and (d) totals 100%, and with the proviso that the total amount of component (b) and component (c) combined is 1 to 40% by weight based on the copolymer, are described along with methods of using such copolymers to solubilize substances which are insoluble in water, substances which are only sparingly soluble in water, and combinations thereof.

  共聚物包含：（a）60至99重量百分比的至少一种单体，选自N-乙烯基内酰胺、N-乙烯酰胺和它们的混合物；（b）1至40重量百分比的至少一种单体，选自支链的C8-C30脂肪族羧酸的乙烯酯；（c）0至30重量百分比的乙酸乙烯酯；和（d）0至39重量百分比的至少一种额外的自由基共聚单体；其中，组分（a）、（b）、（c）和（d）的重量百分比总和为100%，并且有条件规定组分（b）和组分（c）的总和基于共聚物为1至40重量百分比。还描述了使用这样的共聚物来增溶水不溶性物质、水微溶性物质以及它们的组合的方法。