N-(2,3-dimethoxybenzoyl)-N'-(trifluoroacetyl)-ethylenediamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,3-dimethoxybenzoyl)-N'-(trifluoroacetyl)-ethylenediamine
• 英文别名: 2,3-dimethoxy-N-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]benzamide
• 化学式: C₁₃H₁₅F₃N₂O₄
• 分子量: 320.268
• InChiKey: KTKQIAZWBHNOPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三氟乙酸乙酯 、 2,3-二甲氧基苯甲酸 、 1,2-diaminoethane dihydrochloride 在 sodium methylate 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以86%的产率得到N-(2,3-dimethoxybenzoyl)-N'-(trifluoroacetyl)-ethylenediamine
  参考文献：
  名称：

  High Yield Selective Acylation of Polyamines:  Proton as Protecting Group

  摘要：

  An advance in the selective acylation of polyamines having identical or similar amine functions is reported. While nucleophilicity differences between the various amine functions are slight, the corresponding conjugate acids exhibit pK(a) values over a significant range. We have used proton as polyamine protecting group: the monoamine resulting from single deprotonation of a polyammonium compound has allowed for high yields of selective acylation.

  DOI：

  10.1021/ol702206d

文献信息

• High Yield Selective Acylation of Polyamines:  Proton as Protecting Group
  作者：Asmik Oganesyan、Iris A. Cruz、Roberto B. Amador、Nohemy A. Sorto、Jose Lozano、Carlos E. Godinez、Jaime Anguiano、Heather Pace、Ghiwa Sabih、Carlos G. Gutierrez

  DOI：10.1021/ol702206d

  日期：2007.11.1

  An advance in the selective acylation of polyamines having identical or similar amine functions is reported. While nucleophilicity differences between the various amine functions are slight, the corresponding conjugate acids exhibit pK(a) values over a significant range. We have used proton as polyamine protecting group: the monoamine resulting from single deprotonation of a polyammonium compound has allowed for high yields of selective acylation.