1,5-divinyl citrate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,5-divinyl citrate
• 英文别名: 4-Ethenoxy-2-(2-ethenoxy-2-oxoethyl)-2-hydroxy-4-oxobutanoic acid
• 化学式: C₁₀H₁₂O₇
• 分子量: 244.201
• InChiKey: HMMIGGVOUMUQRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  乙酸乙烯酯 、 柠檬酸 在 硫酸 作用下， 以 二甲基亚砜 为溶剂， 反应 48.0h， 以24%的产率得到1,5-divinyl citrate
  参考文献：
  名称：

  Degradable nanoparticles

  摘要：

  本发明涉及聚合物纳米颗粒，特别适用于药物和试剂的输送，以及用于成像和诊断。本发明的聚合物纳米颗粒包括交联剂，当被降解时，会留下简单的线性聚合物分子，可以被人体排泄。本发明还涉及制备本发明的聚合物纳米颗粒的方法，以及在药物和试剂输送、成像和诊断中使用它们的方法。

  公开号：

  US20050196343A1

文献信息

• Biodegradable nanoparticles
  申请人：Erathodiyil Nandanan

  公开号：US20070009441A1

  公开（公告）日：2007-01-11

  The present invention relates to polymeric nanoparticles useful in drug and agent delivery, as well as for imaging, diagnosis and targeting. The polymeric nanoparticles of the present invention comprise polymers and cross-linkers that, when degraded, leave simple nontoxic biocompatible molecules that can be metabolized, excreted, or absorbed by the body. The present invention also relates to processes for producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging, diagnosis and targeting.

  本发明涉及在药物和药剂传递中有用的高分子纳米粒子，以及用于成像、诊断和靶向的高分子纳米粒子。本发明的高分子纳米粒子包括聚合物和交联剂，当其降解时，会留下简单的无毒生物相容分子，可以被身体代谢、排泄或吸收。本发明还涉及制备本发明的高分子纳米粒子的过程，以及在药物和药剂传递、成像、诊断和靶向中使用它们的方法。
• Particulate delivery systems
  申请人：RUBICON RESEARCH PRIVATE LIMITED

  公开号：US10391060B2

  公开（公告）日：2019-08-27

  The present invention provides particulate delivery systems comprising plurality of particles comprising fenugreek gum and at least one pharmaceutically acceptable excipient. The particulate delivery systems of the present invention are used for the delivery of therapeutic, immunologic or diagnostic agents, and the like.

  本发明提供的微粒给药系统由多个包含葫芦巴胶和至少一种药学上可接受的赋形剂的微粒组成。本发明的颗粒给药系统可用于给药治疗剂、免疫剂或诊断剂等。
• PARTICULATE DELIVERY SYSTEMS
  申请人：Pilgaonkar Pratibha

  公开号：US20190000763A1

  公开（公告）日：2019-01-03

  The present invention provides particulate delivery systems comprising plurality of particles comprising fenugreek gum and at least one pharmaceutically acceptable excipient. The particulate delivery systems of the present invention are used for the delivery of therapeutic, immunologic or diagnostic agents, and the like.
• [EN] DEGRADABLE NANOPARTICLES<br/>[FR] NANOPARTICULES DEGRADABLES
  申请人：MOLECULAR THERAPEUTICS INC

  公开号：WO2005089106A2

  公开（公告）日：2005-09-29

  The present invention relates to polymeric nanoparticles, particularly useful in drug and agent delivery, as well as for imaging and diagnosis. The polymeric nanoparticles of the present invention comprise cross-linkers that, when degraded, leave simple linear polymeric molecules that can be excreted by the body. The present invention also relates to methods of producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging and diagnosis.
• [EN] BIODEGRADABLE NANOPARTICLES<br/>[FR] NANOPARTICULES BIODEGRADABLES
  申请人：REDDY G RAMACHANDRA

  公开号：WO2006010083A2

  公开（公告）日：2006-01-26

  The present invention relates to polymeric nanoparticles useful in drug and agent delivery, as well as for imaging, diagnosis and targeting. The polymeric nanoparticles of the present invention comprise polymers and cross-linkers that, when degraded, leave simple nontoxic biocompatible molecules that can be metabolized, excreted, or absorbed by the body. The present invention also relates to processes for producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging, diagnosis and targeting.