α-aminoundec-9-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-aminoundec-9-enoic acid
• 英文别名: (E)-2-aminoundec-9-enoic acid
• 化学式: C₁₁H₂₁NO₂
• 分子量: 199.293
• InChiKey: TXVBPGJHXXCMTB-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  蓖麻油酸 生成 庚酸 、 α-aminoundec-9-enoic acid
  参考文献：
  名称：

  METHOD FOR PRODUCING MEDIUM-CHAIN OMEGA-HYDROXY FATTY ACIDS, ALPHA,OMEGA-DICARBOXYLIC ACIDS, AND OMEGA-AMINO FATTY ACIDS FROM LONG-CHAIN FATTY ACIDS BY BIOTRANSFORMATION

  摘要：

  本发明涉及一种转化体，该转化体被转化以表达Baeyer-Villiger单加氧酶（BVMO），以及通过使用该转化体进行生物转化从C16-C20长链脂肪酸中生产C5-C14中链ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇的方法，以及使用BVMO从酮脂肪酸中引入酯基的脂肪酸衍生物的制备方法和新的ω-羟基脂肪酸。通过使用本发明的能够表达BVMO的转化体进行生物转化，可以从介质中含有的C16到C20长链脂肪酸中大量生产C5到C14的ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸、醇等降解产物。因此，它可以广泛用于更安全、更经济地生产ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇。

  公开号：

  US20150057461A1

文献信息

• METHOD FOR PRODUCING MIDDLE-CHAIN OMEGA-HYDROXY FATTY ACIDS, ALPHA AND OMEGA-DICARBOXYLIC ACIDS, AND OMEGA-AMINO FATTY ACIDS FROM LONG-CHAIN FATTY ACIDS BY BIOTRANSFORMATION
  申请人：Ewha University-Industry Collaboration Foundation

  公开号：EP2835425A1

  公开（公告）日：2015-02-11

  The present invention relates to a transformant which is transformed to express Baeyer-Villiger monooxygenase (BVMO), a method for producing C5-C14 medium-chain ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, or alcohols from C16-C20 long-chain fatty acids by biotransformation using the transformant, a method for producing a fatty acid derivative having an ester group which is introduced into the chain thereof from keto fatty acid using the BVMO, and novel ω-hydroxy fatty acids which are prepared by the method. Degradation products such as C5 to C14 ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, alcohols can be produced in a large amount from C16 to C20 long-chain fatty acids contained in a medium by biotransformation using a transformant capable of expressing BVMO of the present invention. Therefore, it can be widely used to produce ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids or alcohols in a more safe and economic manner.

  本发明涉及一种经转化表达拜耳-维利格单加氧酶（BVMO）的转化体，一种利用转化体通过生物转化从C16-C20长链脂肪酸生产C5-C14中链ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇的方法，一种利用转化体从酮脂肪酸生产具有酯基的脂肪酸衍生物的方法、一种利用 BVMO 生产具有酯基的脂肪酸衍生物的方法，该酯基是利用 BVMO 从酮脂肪酸引入其链中的；以及一种利用该方法制备新型ω-羟基脂肪酸的方法。利用能表达本发明 BVMO 的转化体进行生物转化，可从培养基中所含的 C16 至 C20 长链脂肪酸中产生大量降解产物，如 C5 至 C14 ω-羟基脂肪酸、α,ω-二羧酸、ω-氨基脂肪酸、醇类。因此，它可广泛用于以更安全、更经济的方式生产ω-羟基脂肪酸、α,ω-二羧酸、ω-氨基脂肪酸或醇。
• Use of BVMO (Baeyer-Villiger monooxygenases) and fatty acids
  申请人：Ewha University-Industry Collaboration Foundation

  公开号：EP2835425B1

  公开（公告）日：2018-05-30
• US9745605B2
  申请人：——

  公开号：US9745605B2

  公开（公告）日：2017-08-29
• [EN] METHOD FOR PRODUCING MIDDLE-CHAIN Omega-HYDROXY FATTY ACIDS, AlphaAND Omega-DICARBOXYLIC ACIDS, AND Omega-AMINO FATTY ACIDS FROM LONG-CHAIN FATTY ACIDS BY BIOTRANSFORMATION<br/>[FR] PROCÉDÉ POUR PRODUIRE DES Omega-HYDROXY-ACIDES GRAS À CHAÎNE MOYENNE, DES ACIDES Alpha ET Omega-DICARBOXYLIQUES, ET DES Omega-AMINO-ACIDES GRAS À PARTIR D'ACIDES GRAS À CHAÎNE LONGUE PAR BIOTRANSFORMATION
  申请人：UNIV EWHA IND COLLABORATION

  公开号：WO2013151393A1

  公开（公告）日：2013-10-10

  본 발명은 BVMO(Baeyer-Villiger monooxygenase)를 발현시키도록 형질전환된 형질전환체, 상기 형질전환체를 이용한 생물전환을 통하여 16 내지 20개의 탄소수를 가지는 장쇄 지방산으로부터 5 내지 14개의 탄소수를 가지는 중쇄 오메가-하이드록시지방산, 알파,오메가-디카르복실산, 오메가-아미노지방산 또는 알코올을 생산하는 방법, 상기 BVMO를 이용하여 키토 지방산으로부터 사슬내에 에스터기가 도입된 지방산 유도체를 생산하는 방법 및 상기 방법으로 제조된 신규한 오메가-하이드록시지방산에 관한 것이다. 본 발명의 BVMO를 발현시킬 수 있는 형질전환체를 이용한 생물전환 반응에 의하여, 배지에 포함된 16 내지 20개의 탄소수를 가지는 장쇄 지방산을 분해하여 5 내지 14개의 탄소수를 가지는 오메가-하이드록시지방산, 알파,오메가-디카르복실산, 오메가-아미노지방산, 알코올 등의 분해산물을 대량으로 생성할 수 있으므로, 오메가-하이드록시지방산, 알파,오메가-디카르복실산, 오메가-아미노지방산 또는 알코올의 보다 안전하고 경제적인 생산에 널리 활용될 수 있을 것이다.
• METHOD FOR PRODUCING MEDIUM-CHAIN OMEGA-HYDROXY FATTY ACIDS, ALPHA,OMEGA-DICARBOXYLIC ACIDS, AND OMEGA-AMINO FATTY ACIDS FROM LONG-CHAIN FATTY ACIDS BY BIOTRANSFORMATION
  申请人：EHWA UNIVERSITY - UNIVERSITY COLLABORATION FOUNDATION

  公开号：US20150057461A1

  公开（公告）日：2015-02-26

  The present invention relates to a transformant which is transformed to express Baeyer-Villiger monooxygenase (BVMO), a method for producing C5-C14 medium-chain ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, or alcohols from C16-C20 long-chain fatty acids by biotransformation using the transformant, a method for producing a fatty acid derivative having an ester group which is introduced into the chain thereof from keto fatty acid using the BVMO, and novel ω-hydroxy fatty acids which are prepared by the method. Degradation products such as C5 to C14 ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, alcohols can be produced in a large amount from C16 to C20 long-chain fatty acids contained in a medium by biotransformation using a transformant capable of expressing BVMO of the present invention. Therefore, it can be widely used to produce ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids or alcohols in a more safe and economic manner.

  本发明涉及一种转化体，该转化体被转化以表达Baeyer-Villiger单加氧酶（BVMO），以及通过使用该转化体进行生物转化从C16-C20长链脂肪酸中生产C5-C14中链ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇的方法，以及使用BVMO从酮脂肪酸中引入酯基的脂肪酸衍生物的制备方法和新的ω-羟基脂肪酸。通过使用本发明的能够表达BVMO的转化体进行生物转化，可以从介质中含有的C16到C20长链脂肪酸中大量生产C5到C14的ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸、醇等降解产物。因此，它可以广泛用于更安全、更经济地生产ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇。