N1-(10-aminodecyl)decane-1,10-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N1-(10-aminodecyl)decane-1,10-diamine
• 英文别名: N'-(10-aminodecyl)decane-1,10-diamine
• 化学式: C₂₀H₄₅N₃
• 分子量: 327.597
• InChiKey: GDVDMZPZSMQUNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N1-(10-aminodecyl)decane-1,10-diamine 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 33.0h， 生成 tert‐butyl N‐[({10‐[(10‐{[amino({[(tert‐butoxy)carbonyl]imino})methyl][(tert‐butoxy)carbonyl]amino}decyl)(chlorocarbonyl)amino]decyl}amino)({[(tert‐butoxy)carbonyl]imino})methyl]‐N‐(cyclopropylmethyl)carbamate
  参考文献：
  名称：

  Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

  摘要：

  Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand the currently available arsenal of drugs. We have recently reported an alkyl-guanidine derivative (2), characterized by a symmetrical dimeric structure, as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains. In this study, starting from its chemical scaffold, we synthesized a small library of analogues. Moreover, biological and in vitro pharmacokinetic characterizations were conducted on some selected derivatives, revealing notable properties: broad-spectrum profile, activity against resistant clinical isolates, and appreciable aqueous solubility. Interestingly, 2 seems neither to select for resistant strains nor to macroscopically alter the membranes, but further studies are required to determine the mode of action.

  DOI：

  10.1021/acs.jmedchem.8b00619
• 作为产物：
  描述：

  1-azido-10-bromodecane 在 palladium 10% on activated carbon 、 氢气 、 potassium carbonate 、 三苯基膦 、 potassium iodide 作用下， 以 溶剂黄146 、 异丙醇 、 正丁醇 为溶剂， 反应 81.0h， 生成 N1-(10-aminodecyl)decane-1,10-diamine
  参考文献：
  名称：

  Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

  摘要：

  Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand the currently available arsenal of drugs. We have recently reported an alkyl-guanidine derivative (2), characterized by a symmetrical dimeric structure, as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains. In this study, starting from its chemical scaffold, we synthesized a small library of analogues. Moreover, biological and in vitro pharmacokinetic characterizations were conducted on some selected derivatives, revealing notable properties: broad-spectrum profile, activity against resistant clinical isolates, and appreciable aqueous solubility. Interestingly, 2 seems neither to select for resistant strains nor to macroscopically alter the membranes, but further studies are required to determine the mode of action.

  DOI：

  10.1021/acs.jmedchem.8b00619

文献信息

• One-pot reductive amination of carboxylic acids: a sustainable method for primary amine synthesis
  作者：Robin Coeck、Dirk E. De Vos

  DOI：10.1039/d0gc01441a

  日期：——

  carboxylic acids is a very green, efficient and sustainable method for the production of (bio-based) amines. However, with current technology, this reaction requires two to three reaction steps. Here, we report the first (heterogeneous) catalytic system for the one-pot reductive amination of carboxylic acids to amines, with solely H2 and NH3 as the reactants. This reaction can be performed with relatively cheap

  羧酸的还原胺化是一种非常绿色，高效和可持续的生产（生物基）胺的方法。但是，使用当前技术，该反应需要两到三个反应步骤。在这里，我们报道了第一个（非均相）催化体系，用于仅用H 2和NH 3作反应物将羧酸单胺还原胺化。该反应可以使用相对便宜的钌-钨双金属催化剂在绿色和良性溶剂环戊基甲基醚（CPME）中进行。在高转化率下，伯胺的选择性可达99％。另外，该催化剂是可回收的并且对常见杂质如水和阳离子（例如羧酸钠）具有耐受性。
• Multi-layer hose
  申请人：Asahi Glass Co., Ltd.

  公开号：EP1470910A1

  公开（公告）日：2004-10-27

  A multi-layer hose having a multi-layer structure comprising an inner layer (I) made of a fluorocopolymer and an outer layer (II) made of a polyamide resin, wherein the fluorocopolymer constituting the inner layer (I) is a fluorocopolymer which comprises polymerized units (a) based on tetrafluoroethylene, polymerized units (b) based on ethylene and polymerized units (c) based on itaconic anhydride and/or citraconic anhydride, wherein the molar ratio of (a)/(b) is from 20/80 to 80/20 and the molar ratio of (c)/((a)+(b)) is from 1/10,000 to 5/100 and which has a volume flow rate of from 1 to 1,000 mm3/sec., and the polyamide resin constituting the outer layer (II) is polyamide 11 and/or polyamide 12, which satisfies a condition of (terminal amino group concentration)/(terminal carboxyl group concentration)>1.

  一种具有多层结构的多层软管，包括由含氟聚合物制成的内层(I)和由聚酰胺树脂制成的外层(II)，其中构成内层(I)的含氟聚合物是一种含氟聚合物，它包括基于四氟乙烯的聚合单元(a)、(a)/(b)的摩尔比为 20/80 至 80/20，(c)/((a)+(b))的摩尔比为 1/10,000 至 5/100，体积流量为 1 至 1,000 立方毫米/秒。,构成外层（II）的聚酰胺树脂为聚酰胺 11 和/或聚酰胺 12，其满足（末端氨基浓度）/（末端羧基浓度）>1 的条件。
• US6855787B2
  申请人：——

  公开号：US6855787B2

  公开（公告）日：2005-02-15
• US9125578B2
  申请人：——

  公开号：US9125578B2

  公开（公告）日：2015-09-08
• [EN] BIS[(ALKYLAMINO)ALKYL]AMINES<br/>[FR] BIS[(ALKYLAMINO)ALKYL]AMINES
  申请人：ALBEMARLE CORP

  公开号：WO2010101560A1

  公开（公告）日：2010-09-10

  This invention provides compositions which are aliphatic bis [(alkylamino)alkyl] amines represented by the formula NH(RaNHRb)2 where each Ra is, independently, an aliphatic alkylene group, and each Rb is, independently, an aliphatic alkyl group having at least about three carbon atoms. Processes for forming aliphatic bis[(alkylamino)alkyl]amines are also provided.