thiophene-2,5-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: thiophene-2,5-dicarboxylic acid
• 英文别名: 2,5-furandicarboxylic acid；FDCA；Cyclopenta-3,5-diene-1,3-dicarboxylic acid
• 化学式: C₇H₆O₄
• 分子量: 154.122
• InChiKey: IJANLTMRRQZEJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  thiophene-2,5-dicarboxylic acid 、 R(+)-alpha-甲基苄胺 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 作用下， 生成 5-[[(1R)-1-phenylethyl]carbamoyl]thiophene-2-carboxylic acid
  参考文献：
  名称：

  2-三氟乙酰基噻吩，一种新的有效和选择性的II类组蛋白脱乙酰基酶抑制剂系列。

  摘要：

  II类HDAC抑制剂的鉴定因缺乏有效的酶检测而受阻，在前一篇论文中，开发了两种检测以提高这些酶的效率：将活性位点组氨酸突变为酪氨酸，或使用三氟乙酰胺赖氨酸底物，可进行筛选以鉴定II类HDAC抑制剂。在本文中，已经证明2-三氟乙酰基噻吩抑制II类HDAC，从而导致开发出一系列5-（三氟乙酰基）噻吩-2-甲酰胺，它们是新颖的，有效的和选择性的II类HDAC抑制剂。具有结合的抑制剂的HDAC 4催化域的X射线晶体结构表明，这些化合物是活性位点抑制剂，并以其水合形式结合。

  DOI：

  10.1016/j.bmcl.2008.02.026
• 作为产物：
  描述：

  5-羟甲基糠醛 在 10% Pt/activated carbon 、 氧气 、 碳酸氢钠 作用下， 以 水 为溶剂， 120.0 ℃ 、8.0 MPa 条件下， 以96.46%的产率得到thiophene-2,5-dicarboxylic acid
  参考文献：
  名称：

  [EN] PROCESS FOR THE SELECTIVE OXIDATION OF 5-HYDROXYMETHYLFURFURAL
  [FR] PROCÉDÉ D'OXYDATION SÉLECTIVE DE 5-HYDROXYMÉTHYLFURFURAL

  摘要：

  从5-羟甲基-2-呋喃醛开始，在溶剂、氧化剂、催化剂和可选碱的存在下，选择性生产氧化呋喃衍生物的过程，其特征在于氧化过程在流动状态下连续进行，并提供了改变反应参数的手段。

  公开号：

  WO2015193364A1

文献信息

• ORGANIC/INORGANIC HYBRID NANOPARTICULATES MADE FROM IRON CARBOXYLATES
  申请人：Horcajada-Cortes Patricia

  公开号：US20100209354A1

  公开（公告）日：2010-08-19

  The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active3 pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity for loading with medicaments and in biocompatibility.

  该发明涉及由铁羧酸盐制成的有机金属混合材料制成的纳米颗粒，例如用作对比剂。这些颗粒还可用于封装和导向感兴趣的分子，如活性药物、具有化妆品特性的化合物和标记物。除了其成像的固有特性外，这些纳米颗粒在药物载荷能力和生物相容性方面也表现出良好的结果。
• SOLID INORGANIC/ORGANIC HYBRID WITH MODIFIED SURFACE
  申请人：Horcajada-Cortes Patricia

  公开号：US20100226991A1

  公开（公告）日：2010-09-09

  The invention relates to solid organometallic hybrids with modified surface. Said solid may be used for example for the encapsulation and vectoring of molecules of interest such as active pharmaceutical agents, compounds of interest in cosmetics and markers, for example, contrast agents. Said solids show good results in terms of loading capacity in medicament agents and in biocompatibility.

  该发明涉及具有改性表面的固体有机金属杂化物。所述固体可以用于例如封装和载体化感兴趣的分子，如活性药物剂、化妆品中感兴趣的化合物和标记物，例如对比剂。所述固体在药物剂的装载能力和生物相容性方面表现出良好的结果。
• PROCESS FOR PURIFYING CRUDE FURAN 2,5-DICARBOXYLIC ACID USING HYDROGENATION
  申请人：Eastman Chemical Company

  公开号：EP3333160A1

  公开（公告）日：2018-06-13

  A process to produce a dry purified furan-2,5-dicarboxylic acid (FDCA) is described. After oxidation of 5-(hydroxymethyl)furfural (5-HMF), a crude FDCA stream is produced that is fed to a crystallization zone followed by a solid-liquid displacement zone to form a low impurity slurry stream. The solids in the low impurity slurry stream are dissolved in a dissolution zone to produce a hydrogenation feed that is hydrogenated in a hydrogenation reactor to generate a hydrogenated FDCA composition. The hydrogenated FDCA composition is routed to a crystallization zone to form a crystallized produce stream that is separated from liquid in a solid-liquid separation zone to generate a purified wet cake stream containing FDCA that can be dried in a drying zone to generate a dry purified FDCA product stream.

  描述了一种生产干法纯化呋喃-2,5-二羧酸（FDCA）的工艺。5-(hydroxymethyl)furfural (5-HMF) 氧化后，产生粗 FDCA 流，将其送入结晶区，然后进入固液置换区，形成低杂质浆液流。低杂质浆液流中的固体在溶解区溶解，生成氢化进料，在氢化反应器中氢化，生成氢化 FDCA 组合物。氢化后的 FDCA 组合物进入结晶区，形成结晶产品流，在固液分离区与液体分离，生成含有 FDCA 的净化湿饼流，在干燥区进行干燥，生成干燥的净化 FDCA 产品流。
• Novel compound, and electrophotographic photoreceptor and electrophotographic apparatus made by using the same
  申请人：Sekine Nobuyuki

  公开号：US20070009819A1

  公开（公告）日：2007-01-11

  A compound useful for a positive charge type electrophotographic photoreceptor with high sensitivity for copiers and printers by using such a novel organic material as a charge transport substance in a photosensitive layer and an electrophotographic apparatus using the same. The compound has a structure represented by the following general formula (I). (In the general formula (I), R 1 , R 2 , R 3 , and R 4 each is an alkyl group or the like; R 5 and R 6 each-is an aryl group or the like; and Z represents a structure having the following general formula (F-A), (F-B) or (F-C). (In the formulae, R 7 and R 8 each is an optionally substituted alkyl group; m and n each represents an integer of from 0 to 2; and X is a sulfur atom or an oxygen atom.).
• ACID, SOLVENT, AND THERMAL RESISTANT METAL-ORGANIC FRAMEWORKS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20170008915A1

  公开（公告）日：2017-01-12

  The disclosure provides for thermal, solvent, and/or acid resistant metal organic frameworks and the use of these frameworks in devices and methods for gas separation, gas storage, and catalysis. The disclosure further provides for MOFs that are strong solid acids, and the use of these strong solid acid MOFs in catalytic devices and catalytic methods.