3-hydroxy-1-(2-hydroxyethyl)-5-(4-isopropylphenyl)-4-(thienyl-2-carbonyl)-3-pyrrolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 3-hydroxy-1-(2-hydroxyethyl)-5-(4-isopropylphenyl)-4-(thienyl-2-carbonyl)-3-pyrrolin-2-one
• 英文别名: 4-hydroxy-1-(2-hydroxyethyl)-2-(4-propan-2-ylphenyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
• 化学式: C₂₀H₂₁NO₄S
• 分子量: 371.457
• InChiKey: NWOJLPPYOBJJCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  C.I.酸性橙108 、 4-异丙基苯甲醛 、 2,4-二氧代-4-噻吩-2-基丁酸甲酯 以 1,4-二氧六环 为溶剂， 以71%的产率得到3-hydroxy-1-(2-hydroxyethyl)-5-(4-isopropylphenyl)-4-(thienyl-2-carbonyl)-3-pyrrolin-2-one
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of 5-(Het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones

  摘要：

  A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized compounds was studied.

  DOI：

  10.1134/s1070363220070087

文献信息

• Synthesis and Antimicrobial Activity of 5-(Het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones
  作者：V. L. Gein、D. D. Rubtsova、A. A. Bobyleva、O. V. Ryabova、V. V. Novikova、N. N. Kasimova、A. N. Yankin

  DOI：10.1134/s1070363220070087

  日期：2020.7

  A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized compounds was studied.