Z-Phe-Arg-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Phe-Arg-NH2
• 英文别名: Cbz-l-phenylalanyl-l-arginine amide；benzyl N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
• 化学式: C₂₃H₃₀N₆O₄
• 分子量: 454.529
• InChiKey: DWLNJCVDVXBQJY-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  175
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Z-Phe-Arg-NH2 在 盐酸 、 水 、 苯酚 作用下， 反应 17.0h， 生成 L-精氨酸 、 L-苯丙氨酸
  参考文献：
  名称：

  Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?

  摘要：

  A small library of peptide amides was designed to profile the cathepsin L active site. Within the cathepsin family of cysteine proteases, the first round of selection was on cathepsin L and cathepsin B, and then selected hits were further evaluated for binding to cathepsin K and cathepsin S. Five highly selective sequences with submicromolar affinities towards cathepsin L were identified. An acyloxymethyl ketone warhead was then attached to these sequences. Although these original irreversible inhibitors inactivate cathepsin L, it appears that the nature of the warhead drastically impact the selectivity profile of the resulting covalent inhibitors. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.041
• 作为产物：
  描述：

  L-arginine amide 、 Z-Phe-OCHo 以 水 为溶剂， 反应 0.5h， 以86%的产率得到Z-Phe-Arg-NH2
  参考文献：
  名称：

  Schelhaas, Michael; Glomsda, Simone; Haensler, Marion, Angewandte Chemie, 1996, vol. 108, # 1, p. 82 - 85

  摘要：

  DOI：

文献信息

• Efficient synthesis of protein-oligonucleotide conjugates
  申请人：——

  公开号：US20030092901A1

  公开（公告）日：2003-05-15

  The present invention relates to an improved method for forming a protein-oligonucleotide conjugate. The method is particularly amenable for forming antibody-oligonucleotide conjugates. The invention further concerns the conjugate molecules produced using such improved methods.

  本发明涉及一种用于形成蛋白质-寡核苷酸共轭物的改进方法。该方法尤其适用于形成抗体-寡核苷酸共轭物。本发明还涉及使用这种改进方法生产的共轭分子。
• EFFICIENT SYNTHESIS OF PROTEIN-OLIGONUCLEOTIDE CONJUGATES
  申请人：Beckman-Coulter, Inc.

  公开号：EP1485500A2

  公开（公告）日：2004-12-15
• EP1485500A4
  申请人：——

  公开号：EP1485500A4

  公开（公告）日：2005-12-07
• Cell-based microarrays, and methods for their preparation and use
  申请人：Reddy Parameswara M.

  公开号：US20060292559A1

  公开（公告）日：2006-12-28

  The present invention is in the field of chemistry and biotechnology. The present invention relates to cell-based microarrays, improved methods for forming such arrays, and methods for using such arrays in diagnostics, therapeutics and research. The invention particularly concerns microarrays in which ligands of a target cells are immobilized to the array support via ligand-binding molecules bound to an oligonucleotide that is hybridized to a support-immobilized oligonucleotide.
• US6942972B2
  申请人：——

  公开号：US6942972B2

  公开（公告）日：2005-09-13