二(邻硝基苯基)亚砜 | 30388-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二(邻硝基苯基)亚砜
• 英文名称: 2,2'-dinitrophenyl sulphoxide
• 英文别名: bis-(2-nitro-phenyl) sulfoxide；Bis-(2-nitro-phenyl)-sulfoxid；2.2'-Dinitro-diphenylsulfoxyd；Bis(o-nitrophenyl)sulfoxid；Hydroxy(2-((2-(hydroxy(oxido)amino)phenyl)sulfinyl)phenyl)azane oxide；1-nitro-2-(2-nitrophenyl)sulfinylbenzene
• CAS: 30388-70-6
• 化学式: C₁₂H₈N₂O₅S
• 分子量: 292.272
• InChiKey: WCZWCGYJADVMJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  128
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  二(邻硝基苯基)亚砜 在 双氧水 、 三氟乙酸 作用下， 反应 12.0h， 以82%的产率得到氨苯砜杂质8
  参考文献：
  名称：

  2-氨基-6-芳基磺酰基苯甲腈作为HIV-1的非核苷类逆转录酶抑制剂。

  摘要：

  发现一系列2-氨基-5-芳基硫代苄腈（1）具有抗HIV-1的活性。结构上的改变产生了亚砜（2）和砜（3）。亚砜通常显示出与HIV-1相似的抗病毒活性。然而，砜是最有效的类似物系列，其中一些具有在纳摩尔范围内的抗HIV-1活性。结构活性关系（SAR）研究表明，间位取代基，特别是间位甲基取代基，总是会增加抗病毒活性。然而，最佳的抗病毒活性由芳基磺酰基部分中的两个间位基团都被取代且取代基之一是甲基的化合物表现出来。这种混乱导致化合物3v，3w，3x和3y在低纳摩尔范围内具有针对HIV-1的IC50值。当评估它们对关键的非核苷类逆转录酶抑制剂（NNRTI）相关突变体的广谱抗病毒活性时，所有二元取代的砜3u-z和2-萘基类似物3ee通常显示出对数显性的单摩尔纳米摩尔活性。 V106A和P236L菌株以及针对菌株E138K，V108I和Y188C的亚微摩尔至低纳摩尔活性。然而，他们显示出缺乏针对K10

  DOI：

  10.1021/jm0004906
• 作为产物：
  描述：

  1,2-二硝基苯 在 sodium sulfide 、 乙醇 、 硝酸 作用下， 生成 二(邻硝基苯基)亚砜
  参考文献：
  名称：

  Lobry de Bruyn; Blanksma, Recueil des Travaux Chimiques des Pays-Bas, 1901, vol. 20, p. 116

  摘要：

  DOI：

文献信息

• PREPARATION OF ALKENES BY MILD THERMOLYSIS OF SULFOXIDES
  申请人：Long Timothy Edward

  公开号：US20110230641A1

  公开（公告）日：2011-09-22

  Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the deπvatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO 2 -phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.

  本公开的实施例包括在温和的热解条件下生成烯烃的方法，该方法可以将前体化合物几乎完全转化为烯烃，而无需异构化或层析纯化最终产物。通过选择性阻断去保护氨基和羧基的氨基酸，本公开的方法提供了合成具有乙烯基甘氨酸基团的肽的方法，该肽的乙烯基甘氨酸基团可以位于肽的羧基或氨基端。温和的条件下热解去除o-NO2-苯基取代芳基基团，确保对热敏感的共轭物如带有乙烯基甘氨酸的肽的最小甚至没有损伤。本公开的方法在温和的热解条件下制备不饱和化合物具有实际应用价值。
• Design of Carbon Surface Functional Groups on the Viewpoint of Lubricant Layer Structure
  作者：Toru Yatsue、Heigo Ishihara、Hiroyuki Matsumoto、Hiroshi Tani

  DOI：10.1080/10402000008982411

  日期：2000.1

  Chemical modification technique with X-ray photoelectron spectroscopy has been used for a quantitative analysis of surface functional groups of the carbon overcoats. As the nitrogen content in the carbon overcoat layer increases, the total abundance of functional groups on the carbon overcoat surface increases. The increase of the functional groups leads to an increase of a physisorbed lubricant layer ratio.Increase of the physisorbed layer ratio on the carbon overcoat surface showed a higher durability on the head/disk interface, and decreased the spin-off of the lubricant on a high rotation of the disk. The increase of the physisorbed layer leads to a higher recovery of the lubricant defect by the wear, and the increase of functional groups on the carbon overcoat surface leads to a stronger interaction of the lubricant with the carbon overcoat surface is estimated.
• DING, XIN-TENG;GE, YU;TENG, ZHU;ZHANG, LIN, CHIN. J. ORG. CHEM., 8,(1988) N 2, 141-142
  作者：DING, XIN-TENG、GE, YU、TENG, ZHU、ZHANG, LIN

  DOI：——

  日期：——
• US8580998B2
  申请人：——

  公开号：US8580998B2

  公开（公告）日：2013-11-12
• [EN] PREPARATION OF ALKENES BY MILD THERMOLYSIS OF SULFOXIDES<br/>[FR] PRÉPARATION D'ALCÈNES PAR THERMOLYSE DOUCE DE SULFOXYDES
  申请人：UNIV GEORGIA

  公开号：WO2010068371A2

  公开（公告）日：2010-06-17

  Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the deπvatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO2-phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.