(R)-N-Trifluoroacetyl-2-heptylamine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-N-Trifluoroacetyl-2-heptylamine
• 英文别名: 2,2,2-trifluoro-N-[(2R)-heptan-2-yl]acetamide
• 化学式: C₉H₁₆F₃NO
• 分子量: 211.227
• InChiKey: ZMOGSTKHQWMDST-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基-双(三氟乙酰胺) 、 (R)-(-)-2-氨基庚烷 以 3-甲基-3-戊醇 为溶剂， 生成 (R)-N-Trifluoroacetyl-2-heptylamine
  参考文献：
  名称：

  En Route to (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution of Aliphatic Amines. One-Pot KR/Racemization/KR Sequence Leading to (S)-Amides

  摘要：

  A one-pot sequential process, involving a radical racemization and an enzymatic resolution, provides access to (S)-amides, from racemic amines, with ee and yields ranging from 78 to 94% and 58 to 80%, respectively.

  DOI：

  10.1021/jo900074w

文献信息

• Aliphatic propargylamines as cellular rescue agents
  申请人：University of Saskatchewan

  公开号：US06251950B1

  公开（公告）日：2001-06-26

  The present invention relates to the use of a group of propargylamines of the general formula (I) wherein R1 is hydrogen or CH3 and R2 is (CH2)nCH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.

  本发明涉及使用一组丙炔胺化合物的一般式（I），其中R1为氢或CH3，R2为（CH2）n ，n为0到16的整数，以及它们的盐，作为细胞救助剂用于治疗和预防因细胞凋亡而导致的疾病。一些I式化合物是新颖的。本发明还涉及将这些化合物用于治疗这些疾病，以及制备这些化合物的方法。
• Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries: Part 3
  作者：Ke Huang、Zachary S. Breitbach、Daniel W. Armstrong

  DOI：10.1016/j.tetasy.2006.10.014

  日期：2006.10

  The enantiomeric excess of chiral reagents used in asymmetric syntheses directly affects the reaction selectivity and product purity. In this work, 84 of the more recently available chiral compounds were evaluated to determine their actual enantiomeric composition. These compounds are widely used in asymmetric syntheses as chiral synthons, catalysts, and auxiliaries. These include chiral alcohols, amines, amino alcohols, amides, carboxylic acids, epoxides, esters, ketones, and oxolanes among other classes of compounds. All enantiomeric test results were categorized within five impurity levels (i.e., < 0.01%, 0.01-0.1%, 0.1-1%, 1-10%, and > 10%). The majority of the reagents tested were determined to have enantiomeric impurities over 0.01%, and two of them were found to contain enantiomeric impurities exceeding the 10% level. The most effective enantio selective analysis method was a GC approach using a Chiraldex GTA chiral stationary phase (CSP). This method worked exceedingly well with chiral amines and alcohols. (c) 2006 Elsevier Ltd. All rights reserved.
• ALIPHATIC PROPARGYLAMINES AS CELLULAR RESCUE AGENTS
  申请人：University of Saskatchewan Technologies Inc.

  公开号：EP0996612B1

  公开（公告）日：2003-04-09
• US5840979A
  申请人：——

  公开号：US5840979A

  公开（公告）日：1998-11-24
• US6251950B1
  申请人：——

  公开号：US6251950B1

  公开（公告）日：2001-06-26