3-[{2-[{2-[bis-(2-dodecylcarbamoyl-ethyl)-amino]-ethyl}-{[(2-dodecylcarbamoyl-ethyl)-amino]-ethyl}-(2-dodecylcarbamoyl-ethyl)-amino]-ethyl}-(2-dodecylcarbamoyl-ethyl)-amino]-N-dodecyl-propionamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[{2-[{2-[bis-(2-dodecylcarbamoyl-ethyl)-amino]-ethyl}-{[(2-dodecylcarbamoyl-ethyl)-amino]-ethyl}-(2-dodecylcarbamoyl-ethyl)-amino]-ethyl}-(2-dodecylcarbamoyl-ethyl)-amino]-N-dodecyl-propionamide
• 英文别名: 3-[2-[2-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]-N-dodecylpropanamide
• 化学式: C₉₆H₁₉₂N₁₀O₆
• 分子量: 1582.64
• InChiKey: ZZVWHVWWEVJFIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  29.4
• 重原子数：
  112
• 可旋转键数：
  93
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  188
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  N-十二烷基丙烯酰胺 、 三乙烯四胺 反应 120.0h， 以13%的产率得到3-[2-[2-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]-N-dodecylpropanamide
  参考文献：
  名称：

  WO2008/42973

  摘要：

  公开号：

文献信息

• [EN] AMINE-CONTAINING TRANSFECTION REAGENTS AND METHODS FOR MAKING AND USING SAME<br/>[FR] RÉACTIFS DE TRANSFECTION AMINÉS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2012068176A1

  公开（公告）日：2012-05-24

  There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

  本文提供了一种新型含胺转染化合物及其制备和使用方法。这些化合物通常是通过将一级胺与不饱和化合物反应而获得的。本文还提供了使用含胺转染化合物与其他化合物结合以封装生物活性剂（如核酸）制备的转染复合物。还描述了使用转染复合物进行体内或体外传递生物活性剂的方法。本发明的转染复合物具有很高的效力，因此与已知的类似转染化合物相比，可以在相对较低的剂量下有效调节生物活性。
• [EN] NANOPARTICLE COMPOSITIONS COMPRISING PLGA DERIVATIVES AND A LIPID<br/>[FR] COMPOSITIONS DE NANOPARTICULES COMPORTANT DES DÉRIVÉS DU PLGA ET UN LIPIDE
  申请人：KØBENHAVNS UNIV

  公开号：WO2017158093A1

  公开（公告）日：2017-09-21

  The present invention relates to a nanoparticle composition comprising PLGA derivatives and a lipid. The composition is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

  本发明涉及一种纳米颗粒组合物，包括PLGA衍生物和脂质，该组合物适用于医疗用途。特别地，本发明涉及一种用于传递药物的传递系统，尤其是核酸，具有增强的功效和减少副作用，如对健康组织的毒性和免疫原性的削弱。更精确地说，本发明涉及一种传递系统，包括PLGA和脂质体杂交纳米颗粒，用于传递siRNA。
• Amine-Containing Transfection Reagents and methods for making and using same
  申请人：Yang Zhiwei

  公开号：US20120136073A1

  公开（公告）日：2012-05-31

  There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

  本文提供了一种新型含胺转染化合物及其制备和使用方法。这些化合物通常是通过将一种一级胺与一种不饱和化合物反应而得到的。本文还提供了使用含胺转染化合物与其他化合物结合以封装生物活性物质（如核酸）的转染复合物。还描述了使用该转染复合物进行体内或体外生物活性物质递送的方法。本发明的转染复合物非常有效，因此相对于已知的类似转染化合物，可以在相对较低的剂量下有效调节生物活性。
• AMINE-CONTAINING TRANSFECTION REAGENTS AND METHODS FOR MAKING AND USING SAME
  申请人：Life Technologies Corporation

  公开号：US20150174260A1

  公开（公告）日：2015-06-25

  There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

  本文提供了一种新型的含胺转染化合物及其制备和使用方法。这些化合物通常是通过将主要胺与不饱和化合物反应而得到的。本文还提供了使用含胺转染化合物与其他化合物结合来封装生物活性物质（如核酸）的转染复合物。本文还描述了使用转染复合物在体内或体外传递生物活性物质的方法。本发明的转染复合物具有高效的特性，相对于已知的类似转染化合物，可以在相对较低的剂量下有效地调节生物活性。
• Amine-containing transfection reagents and methods for making and using same
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US10406237B2

  公开（公告）日：2019-09-10

  There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

  本文提供了新型含胺转染化合物及其制造和使用方法。这些化合物通常是通过伯胺与不饱和化合物反应得到的。本文还提供了使用含胺转染化合物与其他化合物结合制成的转染复合物，以封装核酸等生物活性物质。还描述了使用转染复合物在体内或体外递送生物活性剂的方法。与本领域已知的类似转染化合物相比，本发明的转染复合物具有很高的效力，因此能以相对较低的剂量有效地调节生物活性。