5-imino-1,3-di(4-chlorophenyl)imidazolidine-4-thione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-imino-1,3-di(4-chlorophenyl)imidazolidine-4-thione
• 英文别名: 1,3-Bis(4-chlorophenyl)-4-imino-5-sulfanylideneimidazolidin-2-one；1,3-bis(4-chlorophenyl)-4-imino-5-sulfanylideneimidazolidin-2-one
• 化学式: C₁₅H₉Cl₂N₃OS
• 分子量: 350.228
• InChiKey: XFAYEEXGFZZPGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-imino-1,3-di(4-chlorophenyl)imidazolidine-4-thione 、 硫代卡巴肼 以 乙醇 为溶剂， 反应 7.0h， 以52%的产率得到5,7-bis(4-chlorophenyl)-3-hydrazinyl-5H-imidazo[4,5-e][1,2,4]triazin-6(7H)-one
  参考文献：
  名称：

  具有抗肿瘤，抗病毒，抗菌和抗真菌活性的一些新型单-和双-咪唑烷亚氨基硫酮和咪唑烷亚氨基二硫酮的合成，表征和衍生化-第一部分

  摘要：

  使卤代和烷基化的N-芳基氰基硫代甲酰苯胺与亲核试剂三乙胺，肼和二苯基重氮甲烷反应，分别生成N-芳基氰基硫代甲酰苯胺铵盐，硫代氨基脲和2-（芳基氨基）-3,3-二苯基丙烯腈。他们还与芳基-，芳基双异氰酸酯和芳基异硫氰酸酯进行了几种亲电反应，以生成单-和双-咪唑烷亚氨基硫酮和咪唑烷亚氨基二硫酮。硫化氢，取代邻位处理咪唑烷亚氨基硫酮-苯二胺和硫代碳酰肼得到相应的硫代乙内酰脲，喹喔啉和咪唑三嗪衍生物。对几种合成产物进行了针对抗肿瘤，抗病毒，抗微生物和抗真菌菌株的体外生物学评估。大多数测试的化合物显示出显着的活性。

  DOI：

  10.1016/j.ejmech.2009.07.019

文献信息

• Synthesis of some novel imidazolidine derivatives and their metal complexes with biological and antitumor activity
  作者：Shaya Y. Al-Raqa、Ahmed M. Sh. ElSharief、Saied M. E. Khalil、Abdulkhaliq M. Al-Amri

  DOI：10.1002/hc.20244

  日期：——

  5-e] triazine and pyrrolo[2,3-d]imidazole were prepared when the iminothiones were reacted with thiocarbohydrazide and with ethylphenyl acetate, separately. Some of the synthesized compounds exhibited better biological and antitumor activities. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:634–647, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20244

  卤代咪唑（吡嗪，[1,4]重氮辛和喹喔啉）、9,10-蒽醌-[6,7-e]、菲咯啉[5,6-e]咪唑并[4,5-b]吡嗪}和通过咪唑烷亚胺硫酮与相应的二氨基化合物相互作用得到萘并[1,8-ef]咪唑并[4,5-b][1,4]二氮杂。当亚氨基硫酮与硫代碳酰肼和乙酸乙酯分别反应时，制备了咪唑并[4,5-e]三嗪和吡咯并[2,3-d]咪唑。一些合成的化合物表现出更好的生物和抗肿瘤活性。© 2006 Wiley Periodicals, Inc. 杂原子化学 17:634–647, 2006; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20244
• New Types of Mono and Bis Sulfonamides, Tosylamino Acids and Thiosulfonic Ester Derived from Xanthotoxin, Bergapten and Visnagin with Biological Interest
  作者：A. M. Sh. El-Sharief、S. Y. Al-Raqa

  DOI：10.1080/10426500701263521

  日期：2007.6.1

  Xanthotoxin, bergapten, and visnagin sulfonyl chlorides have been reacted with diamines, hydrazine, amino acides, and imidazolidineiminothiones to produce the corresponding mono-, bis-sulfonamide, and tosylamino acid derivatives. Interaction of xanthotoxin-4-sulfonyl chloride with thiohydantoin furnished the respective thiosulfonic ester. The new products exhibited better antibacterial and antifungal activities.
• Synthesis, characterization and derivatization of some novel types of mono- and bis-imidazolidineiminothiones and imidazolidineiminodithiones with antitumor, antiviral, antibacterial and antifungal activities – part I
  作者：Ahmed M. Sh. El-Sharief、Ziad Moussa

  DOI：10.1016/j.ejmech.2009.07.019

  日期：2009.11

  Halogenated and alkylated N-arylcyanothioformanilides were reacted with the nucleophilic reagents triethylamine, hydrazine and diphenyldiazomethane to produce N-arylcyanothioformanilide ammonium salts, a thiosemicarbazide and a 2-(arylamino)-3,3-diphenylacrylonitrile, respectively. They also underwent several types of electrophilic reactions with aryl-, arylbisisocyanates and arylisothiocyanates to

  使卤代和烷基化的N-芳基氰基硫代甲酰苯胺与亲核试剂三乙胺，肼和二苯基重氮甲烷反应，分别生成N-芳基氰基硫代甲酰苯胺铵盐，硫代氨基脲和2-（芳基氨基）-3,3-二苯基丙烯腈。他们还与芳基-，芳基双异氰酸酯和芳基异硫氰酸酯进行了几种亲电反应，以生成单-和双-咪唑烷亚氨基硫酮和咪唑烷亚氨基二硫酮。硫化氢，取代邻位处理咪唑烷亚氨基硫酮-苯二胺和硫代碳酰肼得到相应的硫代乙内酰脲，喹喔啉和咪唑三嗪衍生物。对几种合成产物进行了针对抗肿瘤，抗病毒，抗微生物和抗真菌菌株的体外生物学评估。大多数测试的化合物显示出显着的活性。