trans-3-methyl-4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: trans-3-methyl-4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine
• 英文别名: (2R,3R)-3-methyl-4-(4-nitrophenyl)sulfonyl-2-phenylmorpholine
• 化学式: C₁₇H₁₈N₂O₅S
• 分子量: 362.406
• InChiKey: RVTJDBKYMBHQLP-DYVFJYSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  trans-3-methyl-4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine 在 lithium hydroxide monohydrate 、 丙烷-1-硫醇 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以97%的产率得到trans-Phenmetrazine
  参考文献：
  名称：

  Facile, Efficient, and Catalyst-Free Electrophilic Aminoalkoxylation of Olefins: Scope and Application

  摘要：

  A new one-pot electrophilic aminoalkoxylation reaction using olefin, cyclic ether, amine, and N-bromosuccinimide has been developed. The olefinic substrates and the cyclic ether partners can be flexibly varied to produce a range of amino ether derivatives. This novel protocol has been applied in the facile and efficient synthesis of biologically active morpholine compounds.

  DOI：

  10.1021/ja104168q
• 作为产物：
  描述：

  N-(2-(trans-2-bromo-1-phenylpropoxy)ethyl)-4-nitrobenzenesulfonamide 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以87%的产率得到trans-3-methyl-4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine
  参考文献：
  名称：

  Facile, Efficient, and Catalyst-Free Electrophilic Aminoalkoxylation of Olefins: Scope and Application

  摘要：

  A new one-pot electrophilic aminoalkoxylation reaction using olefin, cyclic ether, amine, and N-bromosuccinimide has been developed. The olefinic substrates and the cyclic ether partners can be flexibly varied to produce a range of amino ether derivatives. This novel protocol has been applied in the facile and efficient synthesis of biologically active morpholine compounds.

  DOI：

  10.1021/ja104168q

文献信息

• Facile, Efficient, and Catalyst-Free Electrophilic Aminoalkoxylation of Olefins: Scope and Application
  作者：Ling Zhou、Chong Kiat Tan、Jing Zhou、Ying-Yeung Yeung

  DOI：10.1021/ja104168q

  日期：2010.8.4

  A new one-pot electrophilic aminoalkoxylation reaction using olefin, cyclic ether, amine, and N-bromosuccinimide has been developed. The olefinic substrates and the cyclic ether partners can be flexibly varied to produce a range of amino ether derivatives. This novel protocol has been applied in the facile and efficient synthesis of biologically active morpholine compounds.