(+)-kopsiyunnanine C3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (+)-kopsiyunnanine C3
• 化学式: C₂₀H₂₄N₂O₂
• 分子量: 324.423
• InChiKey: MFNKGJVBPOITBB-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  54.26
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (+)-kopsiyunnanine C3 、 对甲苯磺酸甲酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以99%的产率得到
  参考文献：
  名称：

  Catalytically Asymmetric Pd/Norbornene Catalysis: Enantioselective Synthesis of (+)-Rhazinal, (+)-Rhazinilam, and (+)-Kopsiyunnanine C1–3

  摘要：

  A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where alpha-aryl tetrahydroquinoline derived phosphoramidite L15 is found to be the optimum ligand. Taking advantage of this transformation, the concise and unified enantioselective syntheses of (+)-rhazinal, (+)-rhazinilam, and (+)-kopsiyunnanine C1, C2, and C3 are realized.

  DOI：

  10.1021/acs.orglett.6b01790
• 作为产物：
  描述：

  (+)-rhazinal 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以100%的产率得到(+)-kopsiyunnanine C3
  参考文献：
  名称：

  Catalytically Asymmetric Pd/Norbornene Catalysis: Enantioselective Synthesis of (+)-Rhazinal, (+)-Rhazinilam, and (+)-Kopsiyunnanine C1–3

  摘要：

  A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where alpha-aryl tetrahydroquinoline derived phosphoramidite L15 is found to be the optimum ligand. Taking advantage of this transformation, the concise and unified enantioselective syntheses of (+)-rhazinal, (+)-rhazinilam, and (+)-kopsiyunnanine C1, C2, and C3 are realized.

  DOI：

  10.1021/acs.orglett.6b01790

文献信息

• Catalytically Asymmetric Pd/Norbornene Catalysis: Enantioselective Synthesis of (+)-Rhazinal, (+)-Rhazinilam, and (+)-Kopsiyunnanine C1–3
  作者：Kun Zhao、Shibo Xu、Chongqing Pan、Xianwei Sui、Zhenhua Gu

  DOI：10.1021/acs.orglett.6b01790

  日期：2016.8.5

  A catalytically asymmetric palladium/norbornene-catalyzed reaction is reported, where alpha-aryl tetrahydroquinoline derived phosphoramidite L15 is found to be the optimum ligand. Taking advantage of this transformation, the concise and unified enantioselective syntheses of (+)-rhazinal, (+)-rhazinilam, and (+)-kopsiyunnanine C1, C2, and C3 are realized.