(E)-N-(3-methylphenyl)-2-phenylethenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-(3-methylphenyl)-2-phenylethenesulfonamide
• 化学式: C₁₅H₁₅NO₂S
• 分子量: 273.356
• InChiKey: IQWVDGULBLDFGG-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-溴-1-丁烯 、 (E)-N-(3-methylphenyl)-2-phenylethenesulfonamide 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成 (E)-N-(2-methylallyl)-2-phenyl-N-(m-tolyl)ethenesulfonamide
  参考文献：
  名称：

  Desulfonylation-Initiated Distal Alkenyl Migration in Copper-Catalyzed Alkenylation of Unactivated Alkenes

  摘要：

  A novel and efficient protocol for desulfonylation-initiated distal alkenyl migration and its application to the elusive alkenylation of unactivated alkenes have been presented. This radical cascade process has successfully achieved the vicinal difluoroalkylalkenylation of unactivated alkenes with excellent chemo-, regio-, and stereoselectivity in high efficiency under mild conditions. The reactions afford previously unknown 3,3-difluoro-S-styrylpiperidin-2-one derivatives or beta-styryl-gamma-difluoroalkyl amines bearing a quaternary stereocenter. This is the first report of difunctionalization of unactivated alkenes through desulfonylation-initiated distal alkenyl migration.

  DOI：

  10.1021/acs.orglett.8b02840
• 作为产物：
  描述：

  苯乙烯 在 4-二甲氨基吡啶 、 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 (E)-N-(3-methylphenyl)-2-phenylethenesulfonamide
  参考文献：
  名称：

  Desulfonylation-Initiated Distal Alkenyl Migration in Copper-Catalyzed Alkenylation of Unactivated Alkenes

  摘要：

  A novel and efficient protocol for desulfonylation-initiated distal alkenyl migration and its application to the elusive alkenylation of unactivated alkenes have been presented. This radical cascade process has successfully achieved the vicinal difluoroalkylalkenylation of unactivated alkenes with excellent chemo-, regio-, and stereoselectivity in high efficiency under mild conditions. The reactions afford previously unknown 3,3-difluoro-S-styrylpiperidin-2-one derivatives or beta-styryl-gamma-difluoroalkyl amines bearing a quaternary stereocenter. This is the first report of difunctionalization of unactivated alkenes through desulfonylation-initiated distal alkenyl migration.

  DOI：

  10.1021/acs.orglett.8b02840

文献信息

• Fused heteroaryl derivatives
  申请人：Hayakawa Masahiko

  公开号：US20070037805A1

  公开（公告）日：2007-02-15

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
• FUSED HETEROARYL DERIVATIVES
  申请人：HAYAKAWA Masahiko

  公开号：US20100137584A1

  公开（公告）日：2010-06-03

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
• US7173029B2
  申请人：——

  公开号：US7173029B2

  公开（公告）日：2007-02-06
• US8067586B2
  申请人：——

  公开号：US8067586B2

  公开（公告）日：2011-11-29