二乙酸氧基二亚甲基酯 | 4082-91-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二乙酸氧基二亚甲基酯
• 英文名称: bis(acetoxymethyl)ether
• 英文别名: diacetoxymethyl ether；bis-acetoxymethyl ether；Bis-acetoxymethyl-aether；α.α'-Diacetoxy-dimethylaether；Di-oxymethylen-diacetat；Oxybismethylene Bisacetate；Methanol, oxybis-, diacetate；acetyloxymethoxymethyl acetate
• CAS: 4082-91-1
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: FCOKLAMVAHWFCI-UHFFFAOYSA-N

物化性质

• 熔点：
  -13 °C
• 沸点：
  60-62 °C(Press: 0.1 Torr)
• 密度：
  1.158 g/cm3(Temp: 24 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2916190090

反应信息

• 作为反应物：
  描述：

  二乙酸氧基二亚甲基酯 、 2,4,6-三氯苯酚 以 邻二氯苯 为溶剂， 生成 1,1'-[氧基二(亚甲基氧基)]二[2,4,6-三氯苯]
  参考文献：
  名称：

  Synthesis of aryl ethers of bis(hydroxymethyl) ether

  摘要：

  通过将聚氧甲醛乙二醇的二烷基酯与苯酚或取代苯酚反应来制备双(羟甲基)醚的方法。在一个首选实施例中，反应在催化剂存在下进行。

  公开号：

  US04021475A1
• 作为产物：
  描述：

  二氯甲基醚 、 sodium acetate 生成 二乙酸氧基二亚甲基酯
  参考文献：
  名称：

  Grassi; Maselli, Gazzetta Chimica Italiana, 1898, vol. 28 II, p. 495,497

  摘要：

  DOI：

文献信息

• Chloracylierung und Bromacylierung von Carbonylverbindungen. II. Analyse der Nebenprodukte
  作者：Peter Bigler、Stefan Schönholzer、Markus Neuenschwander

  DOI：10.1002/hlca.19780610613

  日期：1978.9.20

  Chloroacylation and bromoacylation of carbonyl compounds II. Structure of the by-products

  羰基化合物的氯酰化和溴酰化II。副产品的结构
• SELECTIVE FLUORESCENT PROBE FOR ALDEHYDE DEHYDROGENASE
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20200199092A1

  公开（公告）日：2020-06-25

  High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.

  高乙醛脱氢酶1A1（ALDH1A1）活性已成为识别正常和癌干细胞的一个可靠标志。本文介绍了一种名为AlDeSense的针对乙醛脱氢酶1A1（ALDH1A1）的开启型绿色荧光探针，以及一个相应的无响应试剂Ctrl-AlDeSense。当用ALDH1A1处理时，AlDeSense的荧光强度可增强20倍。通过表面标记抗体染色、肿瘤球体试验和肿瘤生成能力的评估，所披露的结果显示，表现出高AlDeSense信号强度的细胞具有癌干细胞的特性。本文还报告了一种红色类似物，即red-AlDeSense的开发。重要的是，red-AlDeSense是使用d-PeT淬灭机制在红色区域进行开启型传感的少数几个例子之一。
• [EN] BORONATE-MEDIATED DELIVERY OF MOLECULES INTO CELLS<br/>[FR] ADMINISTRATION DE MÉDICAMENT MÉDIÉE PAR LES BORONATE
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2013110005A1

  公开（公告）日：2013-07-25

  Methods for enhancing cellular uptake of cargo molecules by boronating the cargo molecule, particularly with one or more phenylboronic acid groups. Cellular uptake includes at least partial uptake into the cytosol. Boronation includes ligating, crosslinking or otherwise bonding one or more phenylboronic acids substituted to contain a reactive group to a cargo molecule. Boronation also includes ligating, crosslinking or otherwise bonding a phenylboronated oligopeptide to a cargo molecule. The phenylboronate groups are optionally conjugated to the cargo molecule via linking moieties that can be selectively cleaved. The invention includes certain phenylboronates which are boronation reagents, certain boronated oligopeptides and certain boronated peptides and proteins. The invention also includes kits for enhancing cellular uptake of cargo molecules by boronation with one or more phenylboronates or boronated oligopeptides.

  增强货物分子细胞摄取的方法，通过将货物分子硼酸化，特别是与一个或多个苯硼酸基团硼酸化。细胞摄取至少包括部分摄取到细胞质中。硼酸化包括将一个或多个含有反应基团的取代苯硼酸与货物分子连接、交联或以其他方式键合。硼酸化还包括将苯硼酸化的寡肽与货物分子连接、交联或以其他方式键合。可选地，苯硼酸基团通过可以选择性切割的连接基团与货物分子连接。本发明包括某些作为硼酸化试剂的苯硼酸、某些硼酸化的寡肽以及某些硼酸化的肽和蛋白质。本发明还包括通过用一种或多种苯硼酸或硼酸化寡肽硼酸化来增强货物分子细胞摄取的试剂盒。
• N,N?-Diacylated imidazolidines and hexahydropyrimidines
  作者：O. A. Luk'yanov、G. V. Pokhvisneva、T. V. Ternikova

  DOI：10.1007/bf00703698

  日期：1994.8

  A method for the preparation ofN-monoacyl imidazolidines and hexahydropyrimidines (as hydrochlorides) by interaction of monoacylated derivatives of ethylenediamine and trimethylenediamine with chloromethyl methyl ether was developed. Also a method for the preparation ofN,N′-diacylimidazolidines and hexahydropyrimidines either by acylation of their monoacyl derivatives or by reaction of the correspondingN

  开发了一种通过乙二胺和三亚甲基二胺的单酰化衍生物与氯甲基甲醚相互作用制备N-单酰基咪唑烷和六氢嘧啶（作为盐酸盐）的方法。还有一种制备 N,N'-二酰基咪唑烷和六氢嘧啶的方法，通过它们的单酰基衍生物的酰化或通过相应的 N,N'-二酰基亚烷基二胺衍生物与二甲氧基甲烷、二乙酰氧基甲烷、1,3,5-三恶烷或氯甲基甲醚的反应被设计。
• Process for preparing 1,1-disubstituted ethylenic monomers
  申请人：Afinitica Technologies, S. L.

  公开号：EP2927209A1

  公开（公告）日：2015-10-07

  The present invention relates to a process for preparing 1,1-disubstituted ethylene monomers having general formula (I) from a compound of general formula (II) and an active methylene compound of general formula (III) using a catalytic amount of an ammonium or iminium salt in homogeneous phase or supported on a solid substrate. Said process allows the direct synthesis of the monomers and finds application in the preparation of a wide variety of monomers. The products obtained are reactive monomers of high purity which find application in the field of fast curing adhesives.

  本发明涉及一种从一般式（II）的化合物和一般式（III）的活性甲基化合物中，使用铵盐或亚胺盐的催化量在均相或固相载体上制备具有通式（I）的1,1-二取代乙烯单体的方法。该方法允许直接合成单体，并在制备各种单体方面找到应用。所得产品是高纯度的反应性单体，适用于快速固化胶粘剂领域。