二偶氮乙酰基-DL-正亮氨酰-甲酯

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二偶氮乙酰基-DL-正亮氨酰-甲酯
• 英文名称: diazoacetyl-DL-norleucine methyl ester
• 英文别名: diazoacetyl-DL-norleucin methyl ester；diazoacetyl-DL-2-aminohexanoic acid-methyl ester；methyl 2-[[(2E)-2-diazoacetyl]amino]hexanoate
• 化学式: C₉H₁₅N₃O₃
• 分子量: 213.236
• InChiKey: GZUCPCIYJMTPIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] CATHEPSIN-D AND ANGIOGENESIS INHIBITORS AND COMPOSITIONS THEREOF FOR TREATING BREAST CANCER<br/>[FR] INHIBITEURS DE LA CATHEPSINE D ET DE L'ANGIOGENÈSE ET LEURS COMPOSITIONS DE CEUX-CI DESTINÉES AU TRAITEMENT DU CANCER DU SEIN
  申请人：YOGEES BIOINNOVATIONS PRIVATE LTD

  公开号：WO2018163204A1

  公开（公告）日：2018-09-13

  The invention relates to Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer. More particularly, the invention relates to the design and synthesis of inhibitors of Cathepsin D which exhibits antiproliferative activity and also inhibits angiogenesis. The present invention also relates to the compositions thereof for treating breast cancer.

  这项发明涉及Cathepsin-D和抑制血管生成的抑制剂及其组合物，用于治疗乳腺癌。更具体地，该发明涉及设计和合成Cathepsin D的抑制剂，该抑制剂表现出抗增殖活性，并且还抑制血管生成。本发明还涉及用于治疗乳腺癌的这些组合物。
• Immunoassay
  申请人：BOOTS-CELLTECH DIAGNOSTICS LIMITED

  公开号：EP0117648A2

  公开（公告）日：1984-09-05

  There is described an enzyme inhibitor labelled immunoassay for measuring the concentration of an analyte in a sample wherein the substrate for the enzyme forms at least a part of the sample. In a particular embodiment the sample comprises or consists of a milk sample and the inhibitor label is capable of inhibiting the activity of an enzyme capable of clotting milk. Examples are given of suitable inhibitors. The assay described may be used to measure the concentration of progestagens or oestrogens in milk using the techniques of heterogeneous or homogeneous enzyme inhibitor labelled immunoassay. The results of such an assay give an indication of the fertility of a milk producing domestic animal (e. g. a cow) and may be used to diagnose pregnancy of such an animal. Particular compounds for use in the assay are described, as is a kit of reagents for use in the assay.

  本发明描述了一种酶抑制剂标记免疫测定法，用于测量样品中分析物的浓度，其中酶的底物至少构成样品的一部分。在一个特定的实施方案中，样品包括或由牛奶样品组成，抑制剂标签能够抑制能够凝结牛奶的酶的活性。本文举例说明了合适的抑制剂。所述检测方法可用于使用异构或同构酶抑制剂标记免疫检测技术来测量牛奶中孕激素或雌激素的浓度。这种检测的结果可显示产奶家畜（如奶牛）的生育能力，并可用于诊断该家畜是否怀孕。本文介绍了用于该测定法的特定化合物，以及用于该测定法的试剂盒。
• Novel compounds WK-142 and process for preparing the same
  申请人：KITASATO KENKYUSHO

  公开号：EP0236948A2

  公开（公告）日：1987-09-16

  Novel compounds WK-142 having the following formula: wherein X stands for a benzyl group or an isobutyl group and Y stands for an alkyl group, or pharmaceutically acceptable salts thereof, and a cultivating method for preparing the same are disclosed. The novel compounds have acid protease-inhibiting activity.

  本发明公开了具有下式的新型化合物 WK-142（其中 X 代表苄基或异丁基，Y 代表烷基）或其药学上可接受的盐，以及制备该化合物的培养方法。 该新型化合物具有酸性蛋白酶抑制活性。
• Methods for detecting beta amyloid precursor protein processing enzymes
  申请人：Bayer Corporation

  公开号：EP0569777A2

  公开（公告）日：1993-11-18

  Disclosed are methods for regulating formation of beta-amyloid protein with inhibitors of proteases specific for the Precursor to the Alzheimer's Disease beta-amyloid protein, such as inhibitors of aspartic protease, cathepsin D, and a chymotryptic-like serine protease; a method for detecting in vitro protease activity for molecules which possess specificity necessary for the degradation of the Amyloid Precursor Protein; and assays for identifying inhibitors of proteases specific for the Amyloid Precursor Protein.

  公开了用阿尔茨海默病β-淀粉样蛋白前体特异性蛋白酶抑制剂调节β-淀粉样蛋白形成的方法，如天冬氨酸蛋白酶、酪蛋白D和糜蛋白酶样丝氨酸蛋白酶的抑制剂；一种检测体外蛋白酶活性的方法，用于检测具有降解淀粉样前体蛋白所需特异性的分子；以及用于鉴定淀粉样前体蛋白特异性蛋白酶抑制剂的检测方法。
• Compositions and methods for diagnosing or treating psoriasis
  申请人：Celltech R & D, Inc.

  公开号：EP2290080A2

  公开（公告）日：2011-03-02

  In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.

  一方面，本发明提供了编码 CAN-1 多肽或 STG 多肽的分离核酸分子。另一方面，本发明还提供了分离的 STG 多肽、分离的 CAN-1 多肽和分离的 SEEK-1 多肽。另一方面，本发明提供了与 CAN-1、SEEK-1 或 STG 多肽特异性结合的分离抗体。另一方面，本发明提供了诊断或预测个体银屑病易感性的方法。另一方面，本发明提供了改善银屑病症状和/或病情发展的方法。