二仲辛基胺 | 5412-92-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 二仲辛基胺
• 英文名称: bis(2-octyl)amine
• 英文别名: bis-(1-methyl-heptyl)-amine；Bis-(1-methyl-heptyl)-amin；Bis-(α-methyl-n-heptyl)-amin；Di-(sek.-n-octyl)-amin；N-(1-methylheptyl)-2-octanamine；Bis-<1-methyl-heptyl>-amin；2-Octanamine, N-(1-methylheptyl)-；N-octan-2-yloctan-2-amine
• CAS: 5412-92-0
• 化学式: C₁₆H₃₅N
• mdl: MFCD00048901
• 分子量: 241.461
• InChiKey: WFHJRRVARWWPDH-UHFFFAOYSA-N

物化性质

• 熔点：
  14.62°C (estimate)
• 沸点：
  304.24°C (estimate)
• 密度：
  0.8056

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921199090

反应信息

• 作为产物：
  描述：

  仲辛醇 在 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 氟硼酸铵 、 碳酸氢钠 作用下， 反应 17.0h， 以54%的产率得到二仲辛基胺
  参考文献：
  名称：

  通过cp *铱催化的铵盐与醇的多烷基化选择性合成仲胺和叔胺。

  摘要：

  通过Cp * Ir催化的铵盐与醇的无溶剂多烷基化反应已经实现了仲胺和叔胺的有效选择性合成：乙酸铵与醇的反应仅产生叔胺，而四氟硼酸铵的胺选择性地提供了仲胺。使用这种方法，在一锅中由四氟硼酸铵和二醇合成了五元​​和六元仲胺。

  DOI：

  10.1021/ol702522k

文献信息

• Selective Synthesis of Secondary and Tertiary Amines by Cp*Iridium-Catalyzed Multialkylation of Ammonium Salts with Alcohols
  作者：Ryohei Yamaguchi、Shoko Kawagoe、Chiho Asai、Ken-ichi Fujita

  DOI：10.1021/ol702522k

  日期：2008.1.1

  synthesis of secondary and tertiary amines has been achieved by means of Cp*Ir-catalyzed multialkylation of ammonium salts with alcohols without solvent: the reactions of ammonium acetate with alcohols gave tertiary amines exclusively, while those of ammonium tetrafluoroborate afforded secondary amines selectively. Using this method, secondary 5- and 6-membered cyclic amines were synthesized from ammonium

  通过Cp * Ir催化的铵盐与醇的无溶剂多烷基化反应已经实现了仲胺和叔胺的有效选择性合成：乙酸铵与醇的反应仅产生叔胺，而四氟硼酸铵的胺选择性地提供了仲胺。使用这种方法，在一锅中由四氟硼酸铵和二醇合成了五元​​和六元仲胺。
• A New Atom-Economical and Selective Synthesis of Secondary and Tertiary Alkylamines by Means of Cp*Iridium Complex Catalyzed Multiple N-Alkylation of Ammonium Salts with Alcohols without Solvent
  作者：Ryohei Yamaguchi、Ken-ichi Fujita、Zhu Mingwen、Shoko Kawagoe、Chiho Asai

  DOI：10.1055/s-0028-1087996

  日期：2009.4

  A new atom-economical and selective synthetic method for secondary and tertiary alkylamines has been achieved by means of (pentamethylcyclopentadienyl)iridium (Cp*Ir) complex catalyzed multiple N-alkylations of ammonium salts with primary and secondary alcohols without solvent.

  通过使用（五甲基环戊二烯基）铱（Cp*Ir）络合物催化，无需溶剂的情况下，实现了一项针对仲、叔烷基胺的新型原子经济性和选择性合成方法，即对铵盐进行多次N-烷基化反应，原料为伯、仲醇。
• Selective Synthesis of Primary Amines by Reductive Amination of Ketones with Ammonia over Supported Pt catalysts
  作者：Yoichi Nakamura、Kenichi Kon、Abeda Sultana Touchy、Ken-ichi Shimizu、Wataru Ueda

  DOI：10.1002/cctc.201402996

  日期：2015.3

  Supported platinum catalysts are studied for the reductive amination of ketones under ammonia and hydrogen. For a model reaction with 2‐adamantanone, Pt‐loaded MoOx/TiO2 (Pt‐MoOx/TiO2) shows the highest yield of primary amine. The catalyst is effective for the selective transformation of various aliphatic and aromatic ketones to the corresponding primary amines, which demonstrates the first example

  对负载的铂催化剂进行了研究，以在氨和氢下将酮还原胺化。对于与2-金刚烷酮的模型反应，负载Pt的MoO x / TiO 2（Pt-MoO x / TiO 2）显示出最高的伯胺收率。该催化剂对于将各种脂族和芳族酮选择性转化为相应的伯胺是有效的，这证明了通过该反应选择性合成伯胺的第一个实例。在催化剂上吸附的丙酮的红外光谱中，胺的产率随CO伸缩带负移的增加而增加，这表明载体材料上的路易斯酸位在该催化体系中起着重要的作用。
• PHOTOBASE GENERATOR
  申请人：Kuramoto Ayako

  公开号：US20110233048A1

  公开（公告）日：2011-09-29

  There is intended to provide the novel compounds which generate a base easily when irradiated with long wavelength light (active energy rays), a photobase generator containing the compounds and a photobase generation method, and the present invention relates to the compounds represented by the general formula [1], a photobase generator containing the compounds and a photobase generation method: (wherein, Ar represents any of groups with specific structures selected from the group consisting of an anthracenyl group, an anthraquinonyl group and a pyrenyl group; R 1 and R 2 each independently represent a hydrogen atom or a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms, or represent ones which can form an alicyclic ring containing nitrogen atom(s) or an aromatic ring containing nitrogen atom(s) together with a nitrogen atom to which they are bound, which the rings having 3 to 8 carbon atoms which may have a substituent, R 3 and R 4 each independently represent a hydrogen atom, a linear, branched or acyclic alkyl group having 1 to 10 carbon atoms).

  本发明旨在提供当受长波长光（活性能量射线）照射时易于产生碱的新化合物，包含这些化合物的光碱发生器以及光碱生成方法，本发明涉及由通式[1]表示的化合物，包含这些化合物的光碱发生器以及光碱生成方法：（其中，Ar代表从蒽基团、蒽醌基团和芘基团中选择的具有特定结构的任何基团；R1和R2各自独立地代表氢原子或具有1至10个碳原子的直链、支链或环烷基基团，或表示能够与它们结合的氮原子形成含氮原子的脂环烷基环或含氮原子的芳香环，这些环具有3至8个碳原子，可能有取代基；R3和R4各自独立地代表氢原子，具有1至10个碳原子的直链、支链或非环烷基基团）。
• Heterogeneous Ni Catalyst for Direct Synthesis of Primary Amines from Alcohols and Ammonia
  作者：Ken-ichi Shimizu、Kenichi Kon、Wataru Onodera、Hiroshi Yamazaki、Junko N. Kondo

  DOI：10.1021/cs3007473

  日期：2013.1.4

  This paper reports the synthesis of primary amines from alcohols and NH3 by an Al2O3-supported Ni nanoparticle catalyst as the first example of heterogeneous and noble-metal-free catalytic system for this reaction without additional hydrogen sources under relatively mild conditions. Various aliphatic alcohols are tolerated, and turnover numbers were higher than those of Ru-based homogeneous catalysts

  本文报道了由Al 2 O 3由醇和NH 3合成伯胺负载的Ni纳米颗粒催化剂作为该反应的第一个例子，该反应在相对温和的条件下无需额外的氢源即可用于该反应。可以耐受各种脂族醇，其周转数高于Ru基均相催化剂。该催化剂是可回收的并且可以重复使用。研究了镍的氧化态和载体氧化物的酸碱性质对催化活性的影响。清楚的是，表面金属Ni位点是催化活性物质，并且在该催化体系上，在载体表面上酸性位点和碱性位点的共存也是必不可少的。