Disclosed are a process for preparing a chiral sulfoxide compound of general formula I as a single enantiomer or in an enantiomerically enriched form, and S-(-)-levo-omeprazole, S-(-)-levo-pantoprazole and S-(-)-le vo-lansoprazole prepared thereby. Formula (I) omeprazole: R 1=CH 3, R 2=OCH 3, R 3=CH 3, R 4= R 6= R 7=H, R 5=OCH 3 lansoprazole: R 1=H, R 2=OCH 2CF 3, R 3=CH 3, R 4= R 5= R 6= R 7=H pantoprazole: R 1=H, R2=OCH 3, R 3=OCH 3, R 4= R 6= R 7=H, R 5=OCHF 2
本申请公开了一种制备一种手性亚砜化合物的方法,该化合物的通式为I,可以是单对映体或在对映富集形式中存在,并且由此制备的S-(-)-左旋
奥美拉唑、S-(-)-
左旋泮托拉唑和S-(-)-
左旋兰索拉唑。通式(I)
奥美拉唑:R1=
CH3,R2=O ,R3= ,R4= R6= R7=H,R5=O
兰索拉唑:R1=H,R2=OCH2CF3,R3= ,R4= R5= R6= R7=H
泮托拉唑:R1=H,R2=O ,R3=O ,R4= R6= R7=H,R5=OCHF2