二十碳三烯酸（5Z，8Z，14Z） | 90105-02-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 二十碳三烯酸（5Z，8Z，14Z）
• 英文名称: eicosa-5Z,8Z,14Z-trienoic acid
• 英文别名: (5Z,8Z,14Z)-icosa-5,8,14-trienoic acid
• CAS: 90105-02-5
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.5
• InChiKey: MZHLWKPZCXLYSL-IJJPYCETSA-N

物化性质

• 溶解度：
  0.1 M Na2CO3：1.5 mg/ml； DMF：100 mg/ml；二甲基亚砜：100 mg/ml；乙醇：100 mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• USE OF CIS-EPOXYEICOSANTRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO REDUCE PULMONARY INFILTRATION BY NEUTROPHILS
  申请人：Hammock Bruce D.

  公开号：US20100317733A1

  公开（公告）日：2010-12-16

  It has now been discovered that inhibitors of soluble epoxide hydrolase (“sEH”) are useful in reducing the severity of or inhibiting the progression of obstructive pulmonary diseases, restrictive airway diseases, and asthma. Administering a cis-epoxyeicosantrienoic acid (“EET”) in addition to the inhibitor is at least additive, and may be synergistic, in reducing or inhibiting these conditions and diseases, as measured by reduced numbers of neutrophils present in the lung. The inhibitor of sEH may be a nucleic acid, such as a small interfering RNA.

  现在已经发现，可溶性环氧酯酶（“sEH”）的抑制剂对减轻或抑制阻塞性肺疾病、限制性气道疾病和哮喘的进展非常有用。除抑制剂外，给予顺式环氧二十碳三烯酸（“EET”）至少具有加成作用，可能对减轻或抑制这些疾病有协同作用，如通过减少肺部中中性粒细胞的数量来衡量。sEH的抑制剂可以是核酸，例如小干扰RNA。
• US9616017B2
  申请人：——

  公开号：US9616017B2

  公开（公告）日：2017-04-11
• [EN] COMPOSITIONS COMPRISING FATTY ACIDS AND THEIR USE<br/>[FR] COMPOSITIONS COMPRENANT DES ACIDES GRAS ET LEUR UTILISATION
  申请人：NESTEC SA

  公开号：WO2017167415A1

  公开（公告）日：2017-10-05

  The present invention relates to a composition comprising one or more fatty acid derivatives for use in promoting, supporting or optimizing one or more of the following: (i) de novo myelination; (ii) brain structure; (iii) brain connectivity; (iv) intellectual potential; (v) cognitive potential; and (vi) learning potential; (vii) cognitive functioning in an offspring of a female subject, wherein said composition is for administration to the female subject.