二吲哚基顺丁烯二酰亚胺I盐酸 | 176504-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 二吲哚基顺丁烯二酰亚胺I盐酸
• 中文别名: 3-[1-[3-(二甲基氨基)丙基]-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮单盐酸盐
• 英文名称: Bisindolylmaleimide I HCl
• 英文别名: 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;hydrochloride
• CAS: 176504-36-2
• 化学式: C25H25ClN4O2
• 分子量: 448.9
• InChiKey: XRAMWNCMYJHGGH-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMF：10 mg/ml；二甲基亚砜：16 mg/ml； DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  4.06
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• OXAZINYL ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USE
  申请人：Heaton Andrew

  公开号：US20110046722A1

  公开（公告）日：2011-02-24

  The invention provides oxazinyl isoflavonoid compounds and compositions containing same, methods for their preparation and their use as therapeutic agents particularly as cardioprotective, anti-inflammatory, anti-oxidant and chemotherapeutic agents.

  本发明提供了含有噁唑基异黄酮化合物的组合物和组成物，以及它们的制备方法和用作治疗剂，特别是作为心脏保护剂、抗炎剂、抗氧化剂和化疗剂的用途。
• METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS
  申请人：SANOFI

  公开号：US20170216360A1

  公开（公告）日：2017-08-03

  The disclosure relates to methods and compositions for improving homing of cells including mesenchymal stem cells (MSCs). Compositions include compounds described herein as capable of inducing expression by MSCs of cell surface homing ligand molecules such as CD1 la, promoting increased firm adhesion by MSCs in an in vitro shear flow assay, increasing binding to an adhesion molecule such as E-selectin or ICAM-1, and/or demonstrating anti-inflammatory activity upon in vivo systemic administration in cell therapy using human MSCs. Also described are screening methods to identify small molecule compounds for improving a homing function of MSCs.
• US8367659B2
  申请人：——

  公开号：US8367659B2

  公开（公告）日：2013-02-05
• [EN] METHODS AND COMPOSITIONS FOR IMPROVING HOMING OF CELLS INCLUDING MESENCHYMAL STEM CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR AMÉLIORER LE GUIDAGE DE CELLULES SOUCHES MÉSENCHYMATEUSES
  申请人：SANOFI SA

  公开号：WO2015112602A1

  公开（公告）日：2015-07-30

  The disclosure relates to methods and compositions for improving homing of cells including mesenchymal stem cells (MSCs). Compositions include compounds described herein as capable of inducing expression by MSCs of cell surface homing ligand molecules such as CD1 la, promoting increased firm adhesion by MSCs in an in vitro shear flow assay, increasing binding to an adhesion molecule such as E-selectin or ICAM-1, and/or demonstrating anti-inflammatory activity upon in vivo systemic administration in cell therapy using human MSCs. Also described are screening methods to identify small molecule compounds for improving a homing function of MSCs.