Ac-Cys(Boc)-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-Cys(Boc)-OH
• 英文别名: (2R)-3-{[(tert-butoxy)carbonyl]sulfanyl}-2-acetamidopropanoic acid；(2R)-2-acetamido-3-[(2-methylpropan-2-yl)oxycarbonylsulfanyl]propanoic acid
• 化学式: C₁₀H₁₇NO₅S
• 分子量: 263.315
• InChiKey: IQPBUZABCREQMZ-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  氨乙硝酸 、 Ac-Cys(Boc)-OH 在 焦碳酸二乙酯 作用下， 生成 (2R)-N-(2-Nitrooxyethyl)-2-acetylamino-3-tert-butoxycarbonylthiopropanamide
  参考文献：
  名称：

  Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties

  摘要：

  To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00199-9

文献信息

• Regio‐ and Stereoselective Chan‐Lam‐Evans Enol Esterification of Carboxylic Acids with Alkenylboroxines
  作者：Luuk Steemers、Linda Wijsman、Jan H. van Maarseveen

  DOI：10.1002/adsc.201800914

  日期：2018.11.5

  Efficient and scalable Cu(II)‐mediated enol esterification methodology of carboxylic acids from alkenyl boroxines and boronic acids is presented. The reaction shows a wide scope in aliphatic and aromatic carboxylic acids in combination with several alkenyl boroxines. In the case of 2‐substituted alkenyl boroxines the double bond configuration was fully retained in the enol ester product. Also N‐hydroxyimides

  提出了一种高效，可扩展的Cu（II）介导的烯基环硼氧烷和硼酸羧酸的烯醇酯化方法。该反应在脂肪族和芳香族羧酸与几种烯基环硼氧烷化合物的组合中显示出广泛的范围。对于2取代的烯基硼氧烷，双键构型完全保留在烯醇酯产品中。N-羟基酰亚胺和酰亚胺也可以在相应的酰氧基乙烯基烯醇醚和乙烯基酰胺中转化。最后，除甲硫氨酸外，所有其他19种规范氨基酸都显示出它们的相容性，从而以立体选择性方式生成烯醇酯。
• AMINO ACID DERIVATIVE
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0641769A1

  公开（公告）日：1995-03-08

  Constitution: an amino acid derivative represented by the general formula (I): R¹NH-CH(R²)-CONH-A-ONO₂ and a pharmacologically acceptable salt thereof, wherein R¹ represents hydrogen, C₁-C₇ alkanoyl, C₁-C₆ alkoxycarbonyl, C₆-C₁₀ arylcarbonyl, C₇-C₁₃ aralkylcarbonyl, C₇-C₁₃ aralkyloxycarbonyl, or 5- or 6-membered heteroarylcarbonyl; R² represents substituted C₁-C₆ alkyl; and A represents C₂-C₅ alkylene. Effect: this compound is excellent in a collateral vessel dilator activity and an antianginal activity, and hence useful as an antianginal drug.

  构成：通式(I)代表的氨基酸衍生物：R¹NH-CH(R²)-CONH-A-ONO₂ 及其药理学上可接受的盐，其中 R¹ 代表氢、C₁-C₇ 烷酰基C₁-C₆烷氧基羰基、C₆-C₁₀芳基羰基、C₇-C₁₃ 芳基羰基、C₇-C₁₃ 芳基氧基羰基或 5 或 6 元杂芳基羰基；R² 代表取代的 C₁-C₆ 烷基；以及 A 代表 C₂-C₅ 亚烷基。功效：该化合物具有良好的扩张侧支血管活性和抗心绞痛活性，因此可用作抗心绞痛药物。
• US5705527A
  申请人：——

  公开号：US5705527A

  公开（公告）日：1998-01-06