L-tyrosine hexyl ester hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-tyrosine hexyl ester hydrochloride
• 英文别名: hexyl L-tyrosinate hydrochloride；tyrosine hexyl ester chloride；[(2S)-1-hexoxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]azanium;chloride
• 化学式: C₁₅H₂₃NO₃*ClH
• 分子量: 301.813
• InChiKey: GIUCGSNVKZOORK-UQKRIMTDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.81
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  72.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  L-tyrosine hexyl ester hydrochloride 在 聚碳化二亚胺 作用下， 以 乙酸乙酯 为溶剂， 生成 L-酪氨酸,N-[O-氰基-N-[(苯基甲氧基)羰基]-L-酪氨酰]-,己基酯,氰酸酯(ester)
  参考文献：
  名称：

  涉及α-L-氨基酸侧链的聚合反应

  摘要：

  Faisabilite de lapolymerisation de cesaminoacids naturalls via leurs chaineslaterales par des liaisons autres que les liaisons amide

  DOI：

  10.1021/ja00237a030
• 作为产物：
  描述：

  L-酪氨酸 、 正己醇 在 氯化亚砜 作用下， 生成 L-tyrosine hexyl ester hydrochloride
  参考文献：
  名称：

  光学活性聚氨酯二级结构与氢键的相关性及其对红外发射率的影响。

  摘要：

  摘要采用氢转移加成聚合方法，以对映体过量的异氰酸酯-苯酚为原料，合成了旋光度不同的旋光性聚氨酯。随着单体对映体过量的增加，PU的光学活性增强。PU中的螺旋二级结构具有大分子主链的更紧密排列，有助于链间氢键合，并且相应聚合物的红外发射率降低。结果表明，大分子中氢键的顺序和数量在控制红外发射率中起着重要作用。

  DOI：

  10.1016/j.reactfunctpolym.2012.05.006

文献信息

• Synthesis, characterization and infrared emissivity property of optically active polyurethane derived from tyrosine
  作者：Yong Yang、Yuming Zhou、Jianhua Ge、Yongjuan Wang、Xinglan Chen

  DOI：10.1016/j.polymer.2011.06.027

  日期：2011.8

  Optically active polyurethanes (LPU and DPU) and racemic polyurethane (RPU) were synthesized by the self-polyaddition of the isocyanate-phenols which derived from the chiral and racemic tyrosine. All of the polymers were characterized by FT-IR, 1H NMR, GPC, UV–Vis spectroscopy, circular dichroism (CD) spectroscopy, TGA and X-ray diffraction (XRD), and the infrared emissivity values were investigated

  通过自手性和外消旋酪氨酸衍生的异氰酸酯-酚的自聚加成反应合成了旋光性聚氨酯（LPU和DPU）和外消旋聚氨酯（RPU）。所有聚合物均通过FT-IR表征1此外，还对1 H NMR，GPC，UV-Vis光谱，圆二色性（CD）光谱，TGA和X射线衍射（XRD）以及红外发射率值进行了研究。LPU和DPU是两个对映体，与具有随机盘绕分子链的RPU相比，它们具有螺旋构型和更高的氢键结合度。LPU和DPU的结晶度和热分解温度高于RPU，这是由于二级结构更为规则，有利于形成大量链间氢键。因此，LPU和DPU的红外发射率值较低（8–14μm），分别降至0.611和0.625。
• Correlation between the secondary structure and hydrogen bonding in optically active polyurethane and its effect on infrared emissivity
  作者：Yong Yang、Yuming Zhou、Jianhua Ge、Xiaoming Yang

  DOI：10.1016/j.reactfunctpolym.2012.05.006

  日期：2012.9

  Abstract Optically active polyurethanes (PUs) with different specific rotations were synthesized using a hydrogen transfer addition polymerization procedure with isocyanate–phenols of varying enantiomeric excess. The optical activities of the PUs were enhanced with an increase in the enantiomeric excess of the monomers. A helical secondary structure in the PUs with a more compact arrangement of the

  摘要采用氢转移加成聚合方法，以对映体过量的异氰酸酯-苯酚为原料，合成了旋光度不同的旋光性聚氨酯。随着单体对映体过量的增加，PU的光学活性增强。PU中的螺旋二级结构具有大分子主链的更紧密排列，有助于链间氢键合，并且相应聚合物的红外发射率降低。结果表明，大分子中氢键的顺序和数量在控制红外发射率中起着重要作用。
• Biodegradable polymeric drug delivery system with adjuvant activity
  申请人：Massachusetts Institute of Technology

  公开号：US04863735A1

  公开（公告）日：1989-09-05

  An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may be polymer degradation products or an adjuvant which is contained within or bound to the polymer. In one embodiment, the polymer is formed from tyrosine dipeptides. Poly(CTTH-iminocarbonate) is a preferred tyrosine dipeptide polymer for constructing implantable delivery systems for antigenic material. The polymer is not an adjuvant in itself but degrades into products which stimulate the immune system. The tyrosine dipeptide can also be used as a conventional adjuvant. The advantages of the system are that a polymer can be used to form a biodegradable integral structure which is useful as both an implantable source of an antigen or other biologically active compound and as a control means for the rate of release of the biologically active compound, wherein the result is sustained, relatively constant delivery of antigen with simultaneous stimulation of the immune response.

  一种抗原传递系统，利用具有良好机械性能的可生物降解聚合物与刺激免疫系统的材料相结合。具有佐剂活性的材料可以是聚合物降解产物或包含在聚合物中或与聚合物结合的佐剂。在一个实施例中，聚合物由酪氨酸二肽形成。聚（CTTH-亚氨酸酯）是一种用于构建抗原材料可植入传递系统的优选酪氨酸二肽聚合物。该聚合物本身不是佐剂，但会降解成刺激免疫系统的产物。酪氨酸二肽也可以用作传统的佐剂。该系统的优点在于可以使用聚合物形成可生物降解的完整结构，既有助于作为抗原或其他生物活性化合物的可植入来源，又有助于控制生物活性化合物释放速率的手段，从而实现持续、相对恒定的抗原传递并同时刺激免疫反应。
• Optically active polyurethane@indium tin oxide nanocomposite: Preparation, characterization and study of infrared emissivity
  作者：Yong Yang、Yuming Zhou、Jianhua Ge、Xiaoming Yang

  DOI：10.1016/j.materresbull.2012.05.045

  日期：2012.9

  Optically active polyurethane@indium tin oxide and racemic polyurethane@indium tin oxide nanocomposites (LPU@ITO and RPU@ITO) were prepared by grafting the organics onto the surfaces of modified ITO nanoparticles. LPU@ITO and RPU@ITO composites based on the chiral and racemic tyrosine were characterized by FT-IR, UV-vis spectroscopy, X-ray diffraction (XRD), SEM, TEM, and thermo-gravimetric analysis (TGA), and the infrared emissivity values (8-14 mu m) were investigated in addition. The results indicated that the polyurethanes had been successfully grafted onto the surfaces of ITO without destroying the crystalline structure. Both composites possessed the lower infrared emissivity values than the bare ITO nanoparticles, which indicated that the interfacial interaction had great effect on the infrared emissivity. Furthermore, LPU@ITO based on the optically active polyurethane had the virtue of regular secondary structure and more interfacial synergistic actions between organics and inorganics, thus it exhibited lower infrared emissivity value than RPU@ITO based on the racemic polyurethane. (C) 2012 Elsevier Ltd. All rights reserved.
• [EN] MATERIALS AND METHODS OF INTRODUCING GENETIC MATERIAL INTO LIVING CELLS<br/>[FR] MATÉRIAUX ET PROCÉDÉS DESTINÉS À INTRODUIRE UN MATÉRIAU GÉNÉTIQUE DANS DES CELLULES VIVANTES
  申请人：UNIV AKRON

  公开号：WO2008063562A3

  公开（公告）日：2008-10-16