Fe(Tyr)₃

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fe(Tyr)₃
• 英文别名: tris(L-tyrosynato)iron(III)；(2S)-2-amino-3-(4-hydroxyphenyl)propanoate;iron(3+)
• 化学式: C₂₇H₃₀FeN₃O₉
• 分子量: 596.397
• InChiKey: ZQHLVVQRSVSNHI-GJQOQBEKSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -2.97
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  259
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Fe(Tyr)₃ 以 neat (no solvent) 为溶剂， 生成 iron(III) oxide
  参考文献：
  名称：

  Preparation, structural characterization and biological evaluation of l-tyrosinate metal ion complexes

  摘要：

  The complexes formed between different metal ions and biological molecules like amino acids play an important role in human life. Sn(II), Sn(IV), Zn(II), Cd(II), Hg(II), Cr(III), Fe(III), La(III), ZrO(II) and UO(2)(II) complexes are synthesized With L-tyrosine (tyr). These complexes are characterized by elemental analysis, molar conductance, magnetic measurements, mass, IR, UV-vis and (1)H NMR spectra as well as thermogravimetric analysis (TGA/DTG). It has been found from the elemental analysis and the thermal studies that the ligand behaves as bidentate ligand forming chelates with 1:3 (metal:ligand) stoichiometry for trivalent metals and 1:2 for divalent and tetravalent metals. The molar conductance measurements of the complexes in DMSO indicate that the complexes are non-electrolyte. The activation energies and other kinetic parameters were calculated from the Coats-Redfern and Horowitz-Metzger equations. The biological activities of the metal complexes have also been studied against different bacteria and fungi. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2007.08.027
• 作为产物：
  描述：

  iron(III) chloride 、 L-酪氨酸 在 lithium hydroxide monohydrate 作用下， 以 水 为溶剂， 反应 0.58h， 以5.85 g的产率得到Fe(Tyr)₃
  参考文献：
  名称：

  [EN] ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
  [FR] COMPOSÉS ET COMPOSITIONS ANTIMICROBIENS AINSI QUE LEURS UTILISATIONS

  摘要：

  公开号：

  WO2016025448A3

文献信息

• Synthesis and spectroscopic investigations of iron oxide nano-particles for biomedical applications in the treatment of cancer cells
  作者：Aly H. Atta、Mosad A. El-ghamry、Adel Hamzaoui、Moamen S. Refat

  DOI：10.1016/j.molstruc.2014.12.085

  日期：2015.4

  Recently, upon the great importance of synthesized nano-particles especially ferric oxides on medicinal applications, these nano-particles have been prepared here using friendly and low cost biological precursors moieties via a thermal decomposition method. The Fe2O3 nano-particles preparation method is based on thermal degradation of ferric complexes of hippuric acid, itaconic acid, or tyrosine amino acid at 600 degrees C. The used precursors were characterized by several characterization techniques such as microanalysis, conductance, infrared spectra, electronic spectra, and thermogravimetric (TG/DTG). The calcinations stages were identified from the thermogravimetric analyses of ferric complexes. The narrow size distribution in nano-scale range for the Fe2O3 crystals have been studied using X-ray powder diffraction (XRD), scanning electron microscope (SEM), X-ray energy dispersive spectrometer (EDX) and transmission electron microscopy (TEM) analyzer. XRD data indicate that a single phase Fe2O3 nano-particles are obtained with particle size ranging from 20 to 60 nm. The cytotoxic activity of the Fe2O3 nanoparticles was tested against the breast carcinoma cells (MCF-7 cell line). The results of inhibitory concentration fifty (IC50) were existed within the 3.10-3.81 mu g limit. (C) 2015 Elsevier B.V. All rights reserved.