10-isopropoxy-10-oxodecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-isopropoxy-10-oxodecanoic acid
• 英文别名: decanedioic acid mono-isopropyl ester；10-oxo-10-propan-2-yloxydecanoic acid
• 化学式: C₁₃H₂₄O₄
• 分子量: 244.331
• InChiKey: LVOGXJMCDAOKSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-十一烯酸 、 异丙醇 在 臭氧 、 盐酸羟胺 作用下， 反应 48.0h， 以90%的产率得到10-isopropoxy-10-oxodecanoic acid
  参考文献：
  名称：

  羟胺和氨基脲盐酸盐作用下10-十一碳烯酸在各种溶剂中的臭氧分解转化

  摘要：

  研究了可从蓖麻油中获得的 10-十一碳烯酸的臭氧分解转化。开发了几种 α, ω-双功能癸二酸衍生物的合成。

  DOI：

  10.1007/s10600-014-1031-8

文献信息

• [EN] BORON-CONTAINING RHO KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA RHO KINASE CONTENANT DU BORE
  申请人：PERCIPIAD INC

  公开号：WO2021011873A1

  公开（公告）日：2021-01-21

  The present invention provides boron-containing isoquinoline compounds as protein kinase-modulating compounds. These compounds are useful as neuroprotective and neuro-regenerative agents for the amelioration of glaucoma and other ocular neuropathies.

  本发明提供了含硼的异喹啉化合物作为蛋白激酶调节化合物。这些化合物可用作神经保护和神经再生剂，用于改善青光眼和其他眼神经病变。
• [EN] COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT ET/OU LES SOINS DE LA PEAU, DES CHEVEUX, DES ONGLES ET/OU DES MEMBRANES MUQUEUSES
  申请人：LUBRIZOL ADVANCED MATERIALS INC

  公开号：WO2020161683A1

  公开（公告）日：2020-08-13

  The invention relates to a compound of formula (I) R1 - Wm-Xn-AAi - AA2-AA3-AA4-AA5-AA6- Yp-Zq-Ra, a stereoisomer and/or cosmetically acceptable salt thereof wherein: AA1 is Asp, Gly, Asn, Gln, Ala or no amino acid; AA2 is Val, Ile, Leu or Ala; AA3 is Tyr, Phe, Trp, Lys, Arg or His; AA4 is Lys, Arg, His, Pro or Val; AA5 is Asn, Asp, Gln or no amino acid; AA6 is Thr, Ala, Ser or no amino acid. The compounds are useful for the treatment and/or prevention of the symptoms of skin aging and, in particular, for the treatment and/or prevention of skin wrinkles, the treatment and/or prevention of a sagging appearance of the skin, and/or the reduction and/or prevention of facial asymmetry.

  该发明涉及一种化合物，其化学式为（I）R1 - Wm-Xn-AAi - AA2-AA3-AA4-AA5-AA6- Yp-Zq-Ra，以及其立体异构体和/或在化妆品中可接受的盐，其中：AA1为Asp、Gly、Asn、Gln、Ala或无氨基酸；AA2为Val、Ile、Leu或Ala；AA3为Tyr、Phe、Trp、Lys、Arg或His；AA4为Lys、Arg、His、Pro或Val；AA5为Asn、Asp、Gln或无氨基酸；AA6为Thr、Ala、Ser或无氨基酸。这些化合物可用于治疗和/或预防皮肤衰老症状，特别是用于治疗和/或预防皮肤皱纹，治疗和/或预防皮肤松弛外观，以及/或减少和/或预防面部不对称。
• PHARMACEUTICAL COMPOSITION FOR TOPICAL ADMINISTRATION
  申请人：ZIARCO PHARMA LIMITED

  公开号：US20170007576A1

  公开（公告）日：2017-01-12

  The present invention relates to a pharmaceutical composition for topical administration comprising a compound of formula I, 3-4-[2-5-chloro-1-(diphenylmethyl)-2-[2-([2-(trifluoromethyl)benzyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethyl]sulfonyl}phenyl}propanoic acid: or pharmaceutically acceptable salts thereof; and to methods of treating inflammation comprising topical administration of a compositions comprising a compound of formula I.

  本发明涉及一种用于局部给药的药物组成物，包括公式I的化合物，即3-4-[2-5-氯-1-(二苯甲基)-2-[2-([2-(三氟甲基)苯基]磺酰}氨基)乙基]-1H-吲哚-3-基}乙基]磺酰}苯基}丙酸或其药学上可接受的盐；以及治疗炎症的方法，包括局部给药含有公式I的化合物的组合物。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani Giammaria

  公开号：US20110224298A1

  公开（公告）日：2011-09-15

  The present invention relates to a novel use of compounds having the general formula (I): CH 3 (—CH═CH) n —R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH 2 OH, CH 2 O—CO—R′, CO—OR′, CO—O (−) , where R′ is chosen from among H, the alkyl from C 1 to C 22 , each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.

  本发明涉及具有通式（I）的化合物的新用途： CH3（—CH═CH）n—R  (I) 其中n=2至7，R选择自：CHO，CH2OH，CH2O—CO—R′，CO—OR′，CO—O（−），其中R′选择自：H，C1至C22的烷基。每个通式（I）的化合物被用作活性原料，单独或混合使用，用于制备医药或化妆品组合物，通过细胞角蛋白cK-19介导的角蛋白的生产，提高人类表皮细胞修复活性。