4,5-dimethyl-4-cyclohexene-1,2-dicarboxylic anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4,5-dimethyl-4-cyclohexene-1,2-dicarboxylic anhydride
• 英文别名: 6-(6-Carboxy-3,4-dimethylcyclohex-3-ene-1-carbonyl)oxycarbonyl-3,4-dimethylcyclohex-3-ene-1-carboxylic acid
• 化学式: C₂₀H₂₆O₇
• 分子量: 378.422
• InChiKey: XKBQSAYMBQOUBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4,5-dimethyl-4-cyclohexene-1,2-dicarboxylic anhydride 在 二氧化铂 作用下， 以 四氢呋喃 为溶剂， 生成 4,5-dimethylcyclohexene-1,2-dicarboxylic anhydride
  参考文献：
  名称：

  N-(substituted piperazinyl) alkylbicyclic succinimide derivatives

  摘要：

  一种琥珀酰亚胺衍生物的化学式：##STR1## 其中A是直链或支链的C.sub.2 -C.sub.6烷基或烯基，B是直链或支链的C.sub.3 -C.sub.5烷基，D是直链或支链的C.sub.2 -C.sub.3烷基，E是直链或支链的C.sub.2 -C.sub.3烷基，R.sup.1和R.sup.2分别是氢或C.sub.1 -C.sub.4烷基，或它们可以形成单键，R.sup.3是苯基，可选择地取代为C.sub.1 -C.sub.4烷基，C.sub.1 -C.sub.4烷氧基，卤素和/或三氟甲基，一个可选择地取代为卤素的2-吡啶基，一个可选择地取代为卤素的2-嘧啶基，一个化学式的基团：##STR2##（其中R.sup.4是氢或苯基），一个化学式的基团：CO--R.sup.5（其中R.sup.5是金刚烷基或呋喃基）或羟基（C.sub.2 -C.sub.4）烷基，以及其酸盐加合物，可用作抗焦虑药物和/或抗过敏药物。

  公开号：

  US04598078A1
• 作为产物：
  描述：

  马来酸酐 、 2,3-二甲基-1,3-丁二烯 以 苯 为溶剂， 生成 4,5-dimethyl-4-cyclohexene-1,2-dicarboxylic anhydride
  参考文献：
  名称：

  N-(substituted piperazinyl) alkylbicyclic succinimide derivatives

  摘要：

  一种琥珀酰亚胺衍生物的化学式：##STR1## 其中A是直链或支链的C.sub.2 -C.sub.6烷基或烯基，B是直链或支链的C.sub.3 -C.sub.5烷基，D是直链或支链的C.sub.2 -C.sub.3烷基，E是直链或支链的C.sub.2 -C.sub.3烷基，R.sup.1和R.sup.2分别是氢或C.sub.1 -C.sub.4烷基，或它们可以形成单键，R.sup.3是苯基，可选择地取代为C.sub.1 -C.sub.4烷基，C.sub.1 -C.sub.4烷氧基，卤素和/或三氟甲基，一个可选择地取代为卤素的2-吡啶基，一个可选择地取代为卤素的2-嘧啶基，一个化学式的基团：##STR2##（其中R.sup.4是氢或苯基），一个化学式的基团：CO--R.sup.5（其中R.sup.5是金刚烷基或呋喃基）或羟基（C.sub.2 -C.sub.4）烷基，以及其酸盐加合物，可用作抗焦虑药物和/或抗过敏药物。

  公开号：

  US04598078A1

文献信息

• [6-(substituted-methyl)-3-cyclohexenyl] formamide derivative, hair growth promoter and external composition for skin
  申请人：Shiseido Co., Ltd.

  公开号：US06174885B1

  公开（公告）日：2001-01-16

  A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is—(CH2)n-NR2R3; Z is —O—, —OCO—, —OCONR6— or —NR6—; R2 and R3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; —NR5—(CH2)n-NR2R3 or —NR6—(CH2)n-NR2R3 may be Group W, and —OCONR6—(CH2)n-NR2R3 may be —OCO—W, wherein W is a formula of: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, lower alkyl, phenyl or benzyl group; R4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R5 and R6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  一种由以下化学式（I）表示的A［6-（取代甲基）-3-环己烯基］甲酰胺衍生物或其盐：其中A和B中的一个是由R1表示的C10-30的烃基，另一个是-（CH2）n-NR2R3；Z是-O-，-OCO-，-OCONR6-或-NR6-；R2和R3分别表示氢、低碳烷基、苯基或苄基，或者一起表示具有3-7个成员的杂环；-NR5-（CH2）n-NR2R3或-NR6-（CH2）n-NR2R3可以是W组，-OCONR6-（CH2）n-NR2R3可以是-OCO-W，其中W是以下公式：其中环E是包括两个氮原子的6或7个成员的杂环，R2是氢、低碳烷基、苯基或苄基；R4是卤素、低碳烷基、低酰基、硝基、氰基、低烷氧羰基、氨基甲酰基、低烷基甲酰胺基、低烷氧基或低酰氧基；R5和R6中的每一个是氢、低碳烷基、低酰基、低烷基甲酰基，或者是所述W组的一部分；m是0-2的整数；n是0-5的整数。该［6-（取代甲基）-3-环己烯基］甲酰胺衍生物或其盐具有出色的促进头发生长和再生效果，可用于哺乳动物的头发护理、改善或预防脱发，尤其是人类。
• Succinimide derivatives and their production
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0109562A1

  公开（公告）日：1984-05-30

  A succinimide derivative of the formula: wherein A is straight or branched C2-C6 alkylene or alkenylene, B is straight or branched C3-C5 alkylene, D is straight or branched C2-C3 alkylene, E is straight or branched C2-C3 alkylene, R1 and R2 are each hydrogen or C1-C4 alkyl, or they may form a single bond and R3 is a phenyl group optionally substituted with C1-C4 alkyl, C1-C4 alkoxy, halogen and or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: (in which R4 is hydrogen or phenyl), a group of the formula: CO-R5 (in which R5 is adamantyl or furyl) or hydroxy(C2-C4)alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.

  一种琥珀酰亚胺衍生物，其式如下 其中 A 为直链或支链 C2-C6 亚烷基或烯基，B 为直链或支链 C3-C5 亚烷基，D 为直链或支链 C2-C3 亚烷基，E 为直链或支链 C2-C3 亚烷基，R1 和 R2 各为氢或 C1-C4 烷基，或它们可形成单键，R3 为任选被 C1-C4 烷基、C1-C4 烷氧基、卤素和或三氟甲基取代的苯基，任选被卤素取代的 2-吡啶基，任选被卤素取代的 2-嘧啶基，式中的一个基团： (其中 R4 为氢或苯基）、式中的一个基团： CO-R5（其中 R5 为金刚烷基或呋喃基）或羟基（C2-C4）烷基，以及它们的酸加成盐，可用作抗焦虑药和/或抗过敏药。
• 6- (Substituted-methyl) -3- cyclohexenyl formamide derivative, hair growth promoter and external composition for skin
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0940390A1

  公开（公告）日：1999-09-08

  A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is - (CH)n-NR2R3; Z is -O-, -OCO-, -OCONR6- or -NR6-; R2 and R3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; -NR5-(CH)n-NR2R3 or -NR6-(CH)n-NR2R3 may be Group W, and -OCONR6-(CH)n-NR2R3 may be -OCO-W, wherein W is a formula of: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, lower alkyl, phenyl or benzyl group; R4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R5 and R6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  一种[6-(取代-甲基)-3-环己烯基]甲酰胺衍生物或其盐，由下式(I)表示： 其中 A 和 B 中的一个是由 R1 表示的 C10-30 的烃基，另一个是-(CH)n-NR2R3；Z 是-O-、-OCO-、-OCONR6- 或-NR6-；R2 和 R3 分别代表氢、低级烷基、苯基或苄基，或共同代表具有 3-7 个成员的杂环；-NR5-(CH)n-NR2R3 或 -NR6-(CH)n-NR2R3 可以是 W 组，而 -OCONR6-(CH)n-NR2R3 可以是 -OCO-W，其中 W 的式子为： 其中环 E 是包括两个氮原子的 6 或 7 个成员的杂环，R2 是氢、低级烷基、苯基或苄基；R4 是卤素、低级烷基、低级酰基、硝基、氰基、低级烷氧羰基、氨基甲酰基、低级烷基氨基甲酰基、低级烷氨基、低级酰氨基、低级烷氧基或低级酰氧基；R5 和 R6 中的每一个是氢、低级烷基、低级酰基、低级烷基氨基甲酰基或所述 W 组的一部分；m 是 0-2 的整数；n 是 0-5 的整数。6-(取代-甲基)-3-环己烯基]甲酰胺衍生物或其盐具有良好的促进毛发生长和再生的效果，可用于护理、改善或预防哺乳动物，尤其是人类的脱发。
• METAL SALT OF ALICYCLIC DICARBOXYLIC ACID HAVING EXCELLENT DISPERSIBILITY IN POLYOLEFIN RESIN, PRODUCTION METHOD FOR SAID METAL SALT OF ALICYCLIC DICARBOXYLIC ACID, CRYSTAL NUCLEATOR FOR POLYOLEFIN RESIN CONTAINING SAID METAL SALT OF ALICYCLIC DICARBOXYLIC ACID, CRYSTAL NUCLEATOR COMPOSITION CONTAINING SAID CRYSTAL NUCLEATOR, POLYOLEFIN RESIN COMPOSITION, AND POLYOLEFIN RESIN MOLDED ARTICLE
  申请人：New Japan Chemical Co., Ltd.

  公开号：EP3851432A1

  公开（公告）日：2021-07-21

  The purpose of the present invention is to provide a metal salt of an alicyclic dicarboxylic acid which has excellent dispersibility in polyolefin resins, and is thus excellent in crystallinity improving effect that is essential performance as a crystal nucleating agent for polyolefin resins, regardless of processing conditions; a method for producing the metal salt of an alicyclic dicarboxylic acid; a crystal nucleating agent containing the metal salt of an alicyclic dicarboxylic acid; a crystal nucleating agent composition for polyolefin resins containing the crystal nucleating agent and a fatty acid metal salt; a polyolefin resin composition containing the crystal nucleating agent; and a polyolefin resin molded article obtained using the polyolefin resin composition as a raw material. Provided is a metal salt of an alicyclic dicarboxylic acid in which the alicyclic dicarboxylic acid is an alkyl substituent-containing cyclohexane-1,2-dicarboxylic acid, and the metal salt is a calcium salt, a hydroxyaluminum salt, a disodium salt, or a dilithium salt.

  本发明的目的是提供一种脂环族二羧酸金属盐，该金属盐在聚烯烃树脂中具有极佳的分散性，因此无论加工条件如何，作为聚烯烃树脂的晶核剂都具有优异的结晶度改善效果，而这是作为聚烯烃树脂晶核剂的基本性能；一种脂环族二羧酸金属盐的生产方法；含有脂环族二羧酸金属盐的成核剂；含有该成核剂和脂肪酸金属盐的聚烯烃树脂用成核剂组合物；含有该成核剂的聚烯烃树脂组合物；以及以该聚烯烃树脂组合物为原料获得的聚烯烃树脂成型品。本发明提供了一种脂环族二羧酸的金属盐，其中脂环族二羧酸为含烷基取代基的环己烷-1,2-二羧酸，金属盐为钙盐、羟基铝盐、二钠盐或二锂盐。
• Imide derivatives, their production and use
  申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

  公开号：EP0196096B1

  公开（公告）日：1992-04-22