4-(2-diethylaminoethoxy)phenylguanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-diethylaminoethoxy)phenylguanidine
• 英文别名: 2-[4-[2-(Diethylamino)ethoxy]phenyl]guanidine
• 化学式: C₁₃H₂₂N₄O
• 分子量: 250.344
• InChiKey: MEUGCSRWLVHGOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  76.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-dimethylaminoprop-2-en-1-oyl)-6-phenylimidazo[1,2-a]pyridine 、 4-(2-diethylaminoethoxy)phenylguanidine 在 sodium methylate 作用下， 以 正丁醇 为溶剂， 反应 15.0h， 以6%的产率得到2-[4-(2-diethylaminoethoxy)anilino]-4-(6-phenylimidazo[1,2-a]pyrid-3-yl)pyrimidine
  参考文献：
  名称：

  IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES

  摘要：

  公开号：

  EP1214318B1
• 作为产物：
  描述：

  4-(2-(二乙基氨基)乙氧基)-苯胺 、 3,5-二甲基吡唑-1-硝酸咪 以 水 为溶剂， 反应 3.0h， 生成 4-(2-diethylaminoethoxy)phenylguanidine
  参考文献：
  名称：

  IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES

  摘要：

  公开号：

  EP1214318B1

文献信息

• 2-Arylamino-pyrimidines for the treatment of gsk3-related disorders
  申请人：——

  公开号：US20040106574A1

  公开（公告）日：2004-06-03

  An aqueous solution for prophylactic treatment of teats of lactating mammals, comprising as a first component at least partially deacetylated chitosan, or an acid addition salt thereof, in a concentration of up to about 2% by weight of chitosan, the solution having a pH of from about 4 to about 6.8, and said first component having a molecular weight such that the viscosity of the solution is less than about 50 mPas; and a method of prophylactic treatment of teats of lactating mammals.

  一种用于预防治疗泌乳哺乳动物乳头的水溶液，包括作为第一成分的至少部分去乙酰化壳聚糖或其酸加成盐，浓度高达约2%的壳聚糖重量，pH约为4至6.8的溶液，且第一成分具有分子量，使得溶液的粘度小于约50mPas；以及一种预防性治疗泌乳哺乳动物乳头的方法。
• 2-ARYLAMINO-PYRIMIDINES FOR THE TREATMENT OF GSK3-RELATED DISORDERS
  申请人：AstraZeneca AB

  公开号：EP1423388B1

  公开（公告）日：2008-12-03
• US6855719B1
  申请人：——

  公开号：US6855719B1

  公开（公告）日：2005-02-15
• US7078410B2
  申请人：——

  公开号：US7078410B2

  公开（公告）日：2006-07-18
• [EN] IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES<br/>[FR] DERIVES DE IMIDAZO[1,2-A]PYRIDINE ET DE PYRAZOLO[2,3-A]PYRIDINE
  申请人：ASTRAZENECA AB

  公开号：WO2001014375A1

  公开（公告）日：2001-03-01

  A compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid-3-yl or pyrazolo[2,3a]pyrid-3-yl; R2 is as defined within; m is 0-5; wherein the values of R2 may be the same or different; R1 is as defined within; n is 0 to 2, wherein the values of R1 may be the same or different; Ring B is phenyl or phenyl fused to a C¿5-7?cycloalkyl ring; R?3¿ is as defined within; p is 0-4; wherein the values of R3 may be the same or different; R4 is as defined within; q is 0-2; wherein the values of R4 may be the same or different; and wherein p+q≤5; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.