p-nitrobenzyl (2R,5R,6R)-6-dimethylamino-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: p-nitrobenzyl (2R,5R,6R)-6-dimethylamino-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 英文别名: p-nitrobenzyl (2R,5R,6R)-6-dimethylamino-3,7-dioxo-1-azabicyclo[3.2.0)heptane-2-carboxylate；(4-nitrophenyl)methyl (2R,5R,6R)-6-(dimethylamino)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 化学式: C₁₆H₁₇N₃O₆
• 分子量: 347.327
• InChiKey: LYRFVLDIAWKULM-MRVWCRGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  113
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-乙酰基半胱胺 、 p-nitrobenzyl (2R,5R,6R)-6-dimethylamino-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate 生成 p-nitrobenzyl (5R,6R)-3-(2-acetamidoethyl)thio-6-dimethylamino-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  参考文献：
  名称：

  YOSHIKA, TAKEO;CHIDA, NORITAKA;WATANABE, AZUMA;FUKAGAWA, YASUO;ISHIKURA, +

  摘要：

  DOI：
• 作为产物：
  描述：

  (3R,4R)-4-(3-diazo-3-p-nitrobenzyloxycarbonyl-2-oxo)propyl-3-dimethylamino-2-azetidinone 、 乙酸铑(II)二聚物二水合物 以97%的产率得到
  参考文献：
  名称：

  YOSHIKA, TAKEO;CHIDA, NORITAKA;WATANABE, AZUMA;FUKAGAWA, YASUO;ISHIKURA, +

  摘要：

  DOI：

文献信息

• 6-(disubstituted amino)carbapenam compounds
  申请人：Sanraku Incorporated

  公开号：US04812563A1

  公开（公告）日：1989-03-14

  A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an alkyl group or a substituted or unsubstituted aralkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.

  公式表示的化合物为##STR1##其中R.sub.1代表较低的烷基或较低的卤代烷基；R.sub.2代表较低的烷基、较低的卤代烷基、芳基烷基或具有公式--COOR.sub.4或--SO.sub.2R.sub.5的基团，其中R.sub.4代表烷基或取代或未取代的芳基烷基，R.sub.5代表烷基或取代或未取代的芳基；而R.sub.3代表氢原子或可轻松分离的羧基保护基团。该化合物在生产6-(二取代氨基)卡巴胺系抗生素方面有用。
• 6-(disubstituted amino)carbapenem compounds
  申请人：Sanraku Incorporated

  公开号：US04996314A1

  公开（公告）日：1991-02-26

  A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. The compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

  该化合物的化学式为##STR1##其中R.sub.1代表较低的烷基或较低的卤代烷基; R.sub.2代表较低的烷基，较低的卤代烷基，芳基烷基或式子--COOR.sub.4或--SO.sub.2 R.sub.5中的一种，其中R.sub.4代表芳基烷基或取代或未取代的烷基，R.sub.5代表烷基或取代或未取代的芳基; R.sub.3代表氢原子或易于分离的羧基保护基。该化合物在6-(二取代氨基)卡那霉素系列抗生素的生产中有用。式子##STR2##其中R.sub.1和R.sub.2如上所定义，是合成式(I)化合物和/或上述双(取代氨基)卡那霉素系列抗生素的重要中间体。