2-(2-oxazolidinyl)succinic acid dimethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-oxazolidinyl)succinic acid dimethyl ester
• 英文别名: Dimethyl 2-(2-oxo-1,3-oxazolidin-3-yl)butanedioate；dimethyl 2-(2-oxo-1,3-oxazolidin-3-yl)butanedioate
• 化学式: C₉H₁₃NO₆
• 分子量: 231.205
• InChiKey: CSPHPEIHNGKHMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-唑烷酮 、 马来酸二甲酯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 14.0h， 以93%的产率得到2-(2-oxazolidinyl)succinic acid dimethyl ester
  参考文献：
  名称：

  1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-promoted efficient and versatile aza-Michael addition

  摘要：

  A convenient and versatile method was developed for aza-Michael addition using a substoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Various nitrogen nucleophiles were efficiently introduced to a,a-unsaturated carbonyl compounds employing 0.5 equiv of DBU. Furthermore, other heteroatomic nucleophiles could also be introduced successfully under the same reaction conditions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.11.037

文献信息

• 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-promoted efficient and versatile aza-Michael addition
  作者：Chang-Eun Yeom、Mi Jeong Kim、B. Moon Kim

  DOI：10.1016/j.tet.2006.11.037

  日期：2007.1

  A convenient and versatile method was developed for aza-Michael addition using a substoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Various nitrogen nucleophiles were efficiently introduced to a,a-unsaturated carbonyl compounds employing 0.5 equiv of DBU. Furthermore, other heteroatomic nucleophiles could also be introduced successfully under the same reaction conditions. (c) 2006 Elsevier Ltd. All rights reserved.