3-di-n-butylamino-propionamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-di-n-butylamino-propionamide
• 英文别名: N,N-dibutyl-β-alanine amide；N,N-Dibutyl-β-alanin-amid；3-(Dibutylamino)propanamide
• 化学式: C₁₁H₂₄N₂O
• mdl: MFCD00461149
• 分子量: 200.324
• InChiKey: KBXDORNHPJQBGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二正丁胺 、 丙烯酰胺 在 1 mol% HClO4/SiO2 作用下， 以93%的产率得到3-di-n-butylamino-propionamide
  参考文献：
  名称：

  高氯酸浸渍在硅胶上的微波辅助、快速、无溶剂 Aza-Michael 反应

  摘要：

  摘要 高氯酸浸渍硅胶 (HClO4/SiO2) 催化微波辐射条件下，多种胺与 α,β-不饱和羰基化合物的高效无溶剂氮杂-迈克尔加成反应。反应在微波炉中 2-7 分钟内完成，以优异的收率产生相应的加合物，并且催化剂可以回收和重复使用。

  DOI：

  10.1080/00397910902883579

文献信息

• An efficient biomaterial supported bifunctional organocatalyst (ES-SO3− C5H5NH+) for the synthesis of β-amino carbonyls
  作者：Sanny Verma、Suman L. Jain、Bir Sain

  DOI：10.1039/c0ob00965b

  日期：——

  A biomaterial supported organocatalyst, readily synthesized by the reaction of chemically modified sulfonic group containing expanded corn starch with pyridine exhibited excellent catalytic activity for the synthesis of β-amino carbonyls in excellent yields via aza-Michael addition of amines to electron deficient alkenes. A remarkable enhancement in the reaction rates was observed with the prepared bifunctional organocatalyst in comparison to the either starch grafted sulfonic acid or the corresponding homogeneous pyridinium p-toluenesulfonate.

  一种由化学改性的含磺酸基团的膨胀玉米淀粉与吡啶反应合成的生物材料负载型有机催化剂，在胺与缺电子烯烃的aza-Michael加成反应中，表现出优异的催化活性，可高效合成β-氨基羰基化合物。与淀粉接枝磺酸酸或相应的均相吡啶盐-对甲苯磺酸盐相比，所制备的双功能有机催化剂显著提高了反应速率。
• Graphene oxide: an efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes
  作者：Sanny Verma、Harshal P. Mungse、Neeraj Kumar、Shivani Choudhary、Suman L. Jain、Bir Sain、Om P. Khatri

  DOI：10.1039/c1cc15230k

  日期：——

  Graphene oxide was found to be a highly efficient, reusable and cost-effective organocatalyst for the aza-Michael addition of amines to activated alkenes to furnish corresponding β-amino compounds in excellent yields.

  氧化石墨烯被发现是一种高效、可重复使用且成本效益良好的有机催化剂，用于胺与活化烯烃的氮迈克尔加成反应，能以优异的产率制备相应的β-氨基化合物。
• Microwave-Assisted, Rapid, Solvent-Free Aza-Michael Reaction by Perchloric Acid Impregnated on Silica Gel
  作者：Surya Prakash Singh、T. Vijaya Kumar、M. Chandrasekharam、L. Giribabu、P. Yella Reddy

  DOI：10.1080/00397910902883579

  日期：2009.10.21

  Highly efficient solvent-free aza-Michael additions of a variety of amines to α,β-unsaturated carbonyl compounds under microwave-irradiation conditions catalyzed by perchloric acid impregnated on silica gel (HClO4/SiO2) is reported. The reactions are completed within 2–7 min in a microwave oven to produce the corresponding adducts in excellent yields, and the catalyst can be recovered and reused.

  摘要 高氯酸浸渍硅胶 (HClO4/SiO2) 催化微波辐射条件下，多种胺与 α,β-不饱和羰基化合物的高效无溶剂氮杂-迈克尔加成反应。反应在微波炉中 2-7 分钟内完成，以优异的收率产生相应的加合物，并且催化剂可以回收和重复使用。
• Efficient, Simple Preparation of 1,3‐Diamine Derivatives through Addition of Acrylamides with Secondary Amines
  作者：Yi Liu、Ruimao Hua、Xianqing Qiu

  DOI：10.1081/scc-200057283

  日期：2005.5.1

  Abstract Reaction of acrylamides with secondary amines results in the formation of β‐amino‐propionamide through the addition reaction of N–H bond of amines across the double bond of acrylamides in the good to excellent yield. The structure of 2‐methyl‐3‐(1‐piperidinyl)‐propionamide has been determined by X‐ray analysis.

  摘要 丙烯酰胺与仲胺反应通过胺的 N-H 键跨丙烯酰胺双键的加成反应形成 β-氨基-丙酰胺，收率良好至极好。2-甲基-3-(1-哌啶基)-丙酰胺的结构已通过X射线分析确定。
• Carboxamide derivative, processes for producing the same, and detergent composition
  申请人：Yajima Toshio

  公开号：US20070010680A1

  公开（公告）日：2007-01-11

  To provide: a carboxamide derivative having reduced content of amide ester; a method for producing thereof; and a detergent composition containing the carboxamide derivative and having excellent low-temperature stability. One method for producing a carboxamide derivative is to react carboxamide, produced with a manufacturing method of carboxamide including 0.02% by weight to 0.18% by weight of amide ester, with hydrogen peroxide, wherein the method includes a carboxamide synthesis process to synthesize carboxamide by reacting diamine with fatty acid ester at a molar rate of 1.20 to 1.60. Another method for producing a carboxamide derivative is to react the carboxamide with monohaloalkylcarboxylic acid or a salt thereof. A carboxamide derivative is produced by the method for producing a carboxamide derivative. A detergent composition includes the carboxamide derivative. The carboxamide derivative is preferably amidoamine oxide or amide betaine.

  提供一种具有减少酰胺酯含量的羧酰胺衍生物；一种生产该衍生物的方法；以及含有该羧酰胺衍生物并具有优异低温稳定性的洗涤剂组合物。一种生产羧酰胺衍生物的方法是将羧酰胺（由含有0.02重量％至0.18重量％酰胺酯的羧酰胺制造方法制备而成）与过氧化氢反应，其中该方法包括羧酰胺合成过程，通过将二胺与脂肪酸酯以摩尔比1.20至1.60反应合成羧酰胺。另一种生产羧酰胺衍生物的方法是将羧酰胺与单卤代烷基羧酸或其盐反应。通过生产羧酰胺衍生物的方法生产羧酰胺衍生物。洗涤剂组合物包括羧酰胺衍生物。该羧酰胺衍生物最好是酰胺胺氧化物或酰胺甜菜碱。