N-(2-methoxypyridin-3-ylmethyl)-N-(2-phenoxy-phenyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methoxypyridin-3-ylmethyl)-N-(2-phenoxy-phenyl)acetamide
• 英文别名: N-(2-Methoxy-pyridin-3-ylmethyl)-N-(2-phenoxy-phenyl)acetamide；N-[(2-methoxypyridin-3-yl)methyl]-N-(2-phenoxyphenyl)acetamide
• 化学式: C₂₁H₂₀N₂O₃
• 分子量: 348.401
• InChiKey: GNGWNCQBZNYIST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-methoxypyridin-3-ylmethyl)-N-(2-phenoxy-phenyl)acetamide 在 4-二甲氨基吡啶 、 氢溴酸 、 potassium carbonate 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide
  参考文献：
  名称：

  JP5787873

  摘要：

  公开号：
• 作为产物：
  描述：

  2-硝基苯基苯基醚 在 4-二甲氨基吡啶 、 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 28.75h， 生成 N-(2-methoxypyridin-3-ylmethyl)-N-(2-phenoxy-phenyl)acetamide
  参考文献：
  名称：

  JP5787873

  摘要：

  公开号：

文献信息

• ARYLOXYANILIDE DERIVATIVES
  申请人：Wadsworth Harry John

  公开号：US20120003154A1

  公开（公告）日：2012-01-05

  The present invention provides a novel radiolabeled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject.

  本发明提供了一种新型放射性标记的芳氧基脯氨酸衍生物，适用于体内成像。与已知的芳氧基脯氨酸衍生物体内成像剂相比，本发明的体内成像剂具有更好的体内成像性能。本发明的体内成像剂在给予受试者后，表现出良好的选择性结合外周苯二氮平受体（PBR），结合良好的脑吸收和体内动力学。
• Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands
  作者：Taketoshi Okubo、Ryoko Yoshikawa、Shigeyuki Chaki、Shigeru Okuyama、Atsuro Nakazato

  DOI：10.1016/j.bmc.2003.10.050

  日期：2004.1

  Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiological role and functions of PBR have not been fully elucidated. Currently, we presented the pharmacological profile of two high and selective PBR ligands, N-(2,5-dimethoxybenzyl)-N-(4-fluoro-2-phenoxyphenyl)acetamide (7-096, DAA1106) (PBR: IC50 = 0.28 nM) and N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide (7-099, DAA1097) (PBR: IC50=0.92 nM). The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives. The aryloxyanilide derivatives, which have been derived by opening the diazepine ring of 1, are a novel class as PBR ligands and have exhibited high and selective affinity for peripheral benzodiazepine receptors (PBRs). These novel derivatives would be useful for exploring the functions of PBR. In this paper, the design, synthesis and structure-affinity relationships of aryloxyanilide derivatives are described. (C) 2003 Elsevier Ltd. All rights reserved.
• RADIOLABELLED PYRIDINYL DERIVATIVES FOR IN-VIVO IMAGING
  申请人：GE Healthcare Limited

  公开号：EP2408451A2

  公开（公告）日：2012-01-25
• [EN] ARYLOXYANILIDE DERIVATIVES<br/>[FR] DÉRIVÉS D'ARYLOXYANILIDE
  申请人：GE HEALTHCARE LTD

  公开号：WO2010106166A2

  公开（公告）日：2010-09-23

  The present invention provides a novel radiolabeled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject.
• JP5787873
  申请人：——

  公开号：——

  公开（公告）日：——