N-undecylenoyl sarcosine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-undecylenoyl sarcosine
• 英文别名: 2-[Methyl(undec-10-enoyl)amino]acetic acid
• 化学式: C₁₄H₂₅NO₃
• 分子量: 255.357
• InChiKey: QYSOBJBTUIFXRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-十一碳烯基氯酸 、 肌氨酸 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 4.0h， 以94%的产率得到N-undecylenoyl sarcosine
  参考文献：
  名称：

  [EN] N-ACYL SARCOSINES AS ANTIMICROBIALS FOR PRESERVATION OF HOME AND PERSONAL CARE PRODUCTS
  [FR] N-ACYLSARCOSINES EN TANT QU'ANTIMICROBIENS POUR LA CONSERVATION DE PRODUITS D'ENTRETIEN MÉNAGER ET DE SOINS PERSONNELS

  摘要：

  本发明涉及公式I中的N-酰基肌氨酸，其中R = C7烷基和带有末端双键的C10烯基基团，作为家庭和个人护理产品的新型抗菌防腐剂。本专利申请的脂质化肌氨酸可用于保存个人护理行业的乳霜、乳液、乳化液、溶液或悬浮液型配方。这些防腐剂可单独或与其他抗菌剂结合使用，用于“留置”（冷霜、防晒霜）以及“冲洗”（洗面奶、沐浴露、洗发水）型配方中。

  公开号：

  WO2017141266A1

文献信息

• Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 1. Polymerized Anionic Surfactants
  作者：A. Leydet、Ph. Barthelemy、B. Boyer、G. Lamaty、J. P. Roque、A. Bousseau、M. Evers、Y. Henin、R. Snoeck、S. Ikeda、D. Reymen、E. De Clercq

  DOI：10.1021/jm00013a019

  日期：1995.6

  A series of polyanionic compounds was synthesized and evaluated for their activity against human immunodeficiency virus (HIV-1, HIV-2) and various other RNA and DNA viruses. Several compounds, i.e., 2p, 3p, 8p, 13p, 14p, 15p, 17p, 18p, and 19p, proved active against HIV-I within the concentration range of 0.1-3 mu g/mL while not being toxic to the host cells (GEM, MT-4) at concentrations up to 100 mu g/mL or higher. As a rule, these polyanionic compounds proved also active, albeit at somewhat higher concentrations than those required for HIV-1 inhibition, against a number of other enveloped viruses, including HIV-2, human cytomegalovirus, influenza A virus, respiratory syncytial virus, and arenaviruses (Junin and Tacaribe). Among the most potent HIV-1 inhibitors ranked compounds 18p and 19p, the sodium salts of N-methylamides obtained by polymerization of monomers prepared starting from 10-undecenoyl chloride and omega-aminoalkanoic acids.
• N-ACYL SARCOSINES AS ANTIMICROBIALS FOR PRESERVATION OF HOME AND PERSONAL CARE PRODUCTS
  申请人：GALAXY SURFACTANTS LTD.

  公开号：US20210161786A1

  公开（公告）日：2021-06-03

  N-Acyl sarcosines of Formula I, wherein, R═C 7 alkyl and C 10 alkenyl group with terminal double bond, are described as new antimicrobial preservatives for home and personal care products. Lipidated sarcosines of this patent application preserve creams, lotions, emulsions, solutions or suspensions types of formulations of personal care industry. These are used in: leave-on (cold cream sunscreen) as well as: rinse-off” (facewash, body wash, shampoo) formulations either alone or in combination with other antimicrobials.
• [EN] N-ACYL SARCOSINES AS ANTIMICROBIALS FOR PRESERVATION OF HOME AND PERSONAL CARE PRODUCTS<br/>[FR] N-ACYLSARCOSINES EN TANT QU'ANTIMICROBIENS POUR LA CONSERVATION DE PRODUITS D'ENTRETIEN MÉNAGER ET DE SOINS PERSONNELS
  申请人：GALAXY SURFACTANTS LTD

  公开号：WO2017141266A1

  公开（公告）日：2017-08-24

  N-Acyl sarcosines of Formula I, wherein, R = C7 alkyl and C10 alkenyl group with terminal double bond, are described as new antimicrobial preservatives for home and personal care products. Formula I Lipidated sarcosines of this patent application preserve creams, lotions, emulsions, solutions or suspensions types of formulations of personal care industry. These are used in 'leave-on' (cold cream, sunscreen) as well as 'rinse-off' (face wash, body wash, shampoo) formulations either alone or in combination with other antimicrobials.

  本发明涉及公式I中的N-酰基肌氨酸，其中R = C7烷基和带有末端双键的C10烯基基团，作为家庭和个人护理产品的新型抗菌防腐剂。本专利申请的脂质化肌氨酸可用于保存个人护理行业的乳霜、乳液、乳化液、溶液或悬浮液型配方。这些防腐剂可单独或与其他抗菌剂结合使用，用于“留置”（冷霜、防晒霜）以及“冲洗”（洗面奶、沐浴露、洗发水）型配方中。