6-cyano-1-isopropyl-benzoimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 6-cyano-1-isopropyl-benzoimidazole
• 英文别名: 3-Propan-2-ylbenzimidazole-5-carbonitrile；3-propan-2-ylbenzimidazole-5-carbonitrile
• 化学式: C₁₁H₁₁N₃
• 分子量: 185.228
• InChiKey: ULNIXUQVIOBVIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-cyano-1-isopropyl-benzoimidazole 、 、 异丙胺 在 tris(2,2'-bipyridyl)ruthenium dichloride 作用下， 以 neat (no solvent) 为溶剂， 以87%的产率得到3-isopropyl-2-(isopropylamino)-3H-benzo[d]imidazole-5-carbonitrile
  参考文献：
  名称：

  Eco-friendly strategy: design and synthesis of biologically potent benzimidazole–amine hybrids via visible-light generated oxidative C–H arylamylation of analenic amidines

  摘要：

  An operationally simple visible light mediated intramolecular cyclization of benzimidazole to 2-amino benzimidazole hybrid. The disclosed procedure is rapid and the convenient synthesis of benzimidazole-amine hybrids from easily available substituted cyclic, acyclic amines, and benzimidazole under neat conditions in the presence of catalyst tris(2,2-bipyridine)ruthenium(II) chloride. Indubitably this methodology gives a facile and straightforward pathway to construct benzimidazole-amine hybrid derivatives in an eco-friendly fashion. The reaction proved to be economical interims of product yield, low loading of catalyst under solvent free condition. The solvent free method has supreme importance in industrial research. The scope and efficiency of this new green method is significantly better than the existing methods. (C) 2015 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2015.10.042
• 作为产物：
  描述：

  1H-苯咪唑-5-腈 、 2-碘代丙烷 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 生成 6-cyano-1-isopropyl-benzoimidazole 、 5-氰基-1-异丙基苯并咪唑
  参考文献：
  名称：

  N-杂环卡宾作为表面增强拉曼光谱的强大平台

  摘要：

  表面增强拉曼光谱 (SERS) 支持广泛的商业和基础应用。SERS 通常依赖于与贵金属表面结合的配体，通常是硫醇。直接硫醇合成的困难加上它们在表面上的不稳定性突出了对替代配体设计的需求。我们展示了第一个利用 N-杂环卡宾配体的 SERS 示例。介绍了功能化 NHC-CO2 加合物的一般三步合成。这些配体在无溶剂和无碱条件下沉积在 SERS 活性金膜纳米球基底 (AuFON) 上，从而防止结垢。发现所得薄膜坚固且能够进行合成后修饰。

  DOI：

  10.1021/jacs.7b12779

文献信息

• NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3279997A1

  公开（公告）日：2018-02-07

  The purpose of the present invention is to provide a nonaqueous electrolyte that contains acetonitrile having an excellent balance between viscosity and the dielectric constant and a fluorine-containing inorganic lithium salt, wherein the generation of complex cations comprising a transition metal and acetonitrile is suppressed, excellent load characteristics are exhibited, and increases in internal resistance upon repeated charge/discharge cycles are suppressed; a further purpose of the present invention is to provide a nonaqueous secondary battery. The present invention relates to a nonaqueous electrolyte which contains: a nonaqueous solvent comprising acetonitrile; a fluorine-containing inorganic lithium salt; and a specific nitrogenous cyclic compound typified by benzotriazole.

  本发明的目的是提供一种非水电解液，该电解液含有在粘度和介电常数之间具有极佳平衡的乙腈和含氟无机锂盐，其中包含过渡金属和乙腈的复合阳离子的生成受到抑制，显示出极佳的负载特性，并且在重复充放电循环中内阻的增加受到抑制；本发明的另一个目的是提供一种非水二次电池。本发明涉及一种非水电解液，其中包含：由乙腈组成的非水溶剂；含氟无机锂盐；以及以苯并三唑为典型代表的特定含氮环状化合物。
• Eco-friendly strategy: design and synthesis of biologically potent benzimidazole–amine hybrids via visible-light generated oxidative C–H arylamylation of analenic amidines
  作者：I.R. Siddiqui、Farah Ibad、Afshan Ibad、Malik Abdul Waseem、Geeta Watal

  DOI：10.1016/j.tetlet.2015.10.042

  日期：2016.1

  An operationally simple visible light mediated intramolecular cyclization of benzimidazole to 2-amino benzimidazole hybrid. The disclosed procedure is rapid and the convenient synthesis of benzimidazole-amine hybrids from easily available substituted cyclic, acyclic amines, and benzimidazole under neat conditions in the presence of catalyst tris(2,2-bipyridine)ruthenium(II) chloride. Indubitably this methodology gives a facile and straightforward pathway to construct benzimidazole-amine hybrid derivatives in an eco-friendly fashion. The reaction proved to be economical interims of product yield, low loading of catalyst under solvent free condition. The solvent free method has supreme importance in industrial research. The scope and efficiency of this new green method is significantly better than the existing methods. (C) 2015 Published by Elsevier Ltd.
• <i>N</i>-Heterocyclic Carbenes as a Robust Platform for Surface-Enhanced Raman Spectroscopy
  作者：Joseph F. DeJesus、Michael J. Trujillo、Jon P. Camden、David M. Jenkins

  DOI：10.1021/jacs.7b12779

  日期：2018.1.31

  commercial and fundamental applications. SERS often relies on ligands, usually thiols, bound to a noble metal surface. The difficulty of straightforward thiol synthesis combined with their instability on surfaces highlights the need for alternative ligand design. We present the first example of SERS utilizing N-heterocyclic carbene ligands. A general three step synthesis is presented for functionalized NHC-CO2

  表面增强拉曼光谱 (SERS) 支持广泛的商业和基础应用。SERS 通常依赖于与贵金属表面结合的配体，通常是硫醇。直接硫醇合成的困难加上它们在表面上的不稳定性突出了对替代配体设计的需求。我们展示了第一个利用 N-杂环卡宾配体的 SERS 示例。介绍了功能化 NHC-CO2 加合物的一般三步合成。这些配体在无溶剂和无碱条件下沉积在 SERS 活性金膜纳米球基底 (AuFON) 上，从而防止结垢。发现所得薄膜坚固且能够进行合成后修饰。