ethyl N-[(2-thioxo-1,2-dihydropyridin-3-yl)carbonyl]glycinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl N-[(2-thioxo-1,2-dihydropyridin-3-yl)carbonyl]glycinate
• 英文别名: ethyl 2-[(2-sulfanylidene-1H-pyridine-3-carbonyl)amino]acetate
• 化学式: C₁₀H₁₂N₂O₃S
• 分子量: 240.283
• InChiKey: JQNHYAADUVMNRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  99.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl N-[(2-thioxo-1,2-dihydropyridin-3-yl)carbonyl]glycinate 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以96%的产率得到N-[(2-thioxo-1,2-dihydropyridin-3-yl)carbonyl]glycine
  参考文献：
  名称：

  [EN] PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS
  [FR] PROCÉDÉ DE DÉPIGMENTATION DE MATIÈRES KÉRATINIQUES AU MOYEN DE COMPOSÉS DE THIOPYRIDINONE

  摘要：

  该发明涉及一种用于脱色、美白和/或漂白角蛋白材料，特别是皮肤的化妆过程，包括应用包含化合物的化妆品组合物的步骤：化合物的化学式为(I)。该发明还涉及化学式(I)的新化合物，含有该化合物的组合物，以及将化合物(I)作为漂白、美白和/或脱色角蛋白材料的剂的化妆用途。

  公开号：

  WO2017102349A1
• 作为产物：
  描述：

  ethyl N-[(2-chloropyridin-3-yl)carbonyl]glycinate 在 盐酸 、 sodium thiosulfate 作用下， 以 水 为溶剂， 反应 6.0h， 生成 ethyl N-[(2-thioxo-1,2-dihydropyridin-3-yl)carbonyl]glycinate
  参考文献：
  名称：

  [EN] PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS
  [FR] PROCÉDÉ DE DÉPIGMENTATION DE MATIÈRES KÉRATINIQUES AU MOYEN DE COMPOSÉS DE THIOPYRIDINONE

  摘要：

  该发明涉及一种用于脱色、美白和/或漂白角蛋白材料，特别是皮肤的化妆过程，包括应用包含化合物的化妆品组合物的步骤：化合物的化学式为(I)。该发明还涉及化学式(I)的新化合物，含有该化合物的组合物，以及将化合物(I)作为漂白、美白和/或脱色角蛋白材料的剂的化妆用途。

  公开号：

  WO2017102349A1

文献信息

• PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS
  申请人：L'OREAL

  公开号：EP3390363B1

  公开（公告）日：2019-09-18
• [EN] STABILIZATION OF THIOPYRIDINONE COMPOUND AND YELLOWING REDUCTION OF COMPOSITION COMPRISING SAME<br/>[FR] STABILISATION D'UN COMPOSÉ THIOPYRIDINONE ET RÉDUCTION DU JAUNISSEMENT D'UNE COMPOSITION LE COMPRENANT
  申请人：[en]L'OREAL

  公开号：WO2022138471A1

  公开（公告）日：2022-06-30

  The present invention relates to a composition comprising: (a) at least one thiopyridinone compound; and (b) at least one fatty acid comprising 18 or more carbon atoms, wherein the amount of the (b) fatty acid(s) comprising 18 or more carbon atoms in the composition is 10% by weight or more, preferably 12% by weight or more, and more preferably 14% by weight or more, relative to the total weight of the composition. The present invention can provide a composition including (a) thiopyridinone compound(s) with increased stability of the (a) thiopyridinone compound(s) over time, in particular even when the composition is maintained for a relatively long period of time under elevated temperature, and with reduced yellowing just after adding the thiopyridinone compound to the composition.
• [EN] STABILIZATION OF THIOPYRIDINONE COMPOUND IN W/O COMPOSITION<br/>[FR] STABILISATION D'UN COMPOSÉ DE THIOPYRIDINONE DANS UNE COMPOSITION EAU-DANS-HUILE
  申请人：[en]L'OREAL

  公开号：WO2022138472A1

  公开（公告）日：2022-06-30

  The present invention relates to a composition comprising: (a) at least one thiopyridinone compound; (b) at least one oil; and (c) water, wherein the composition comprises a continuous oil phase comprising the (b) at least one oil, a discontinuous aqueous phase comprising the (a) thiopyridinone compound and (c) water, dispersed in the oil phase, and the weight ratio of the aqueous phase to the oil phase is 1.0 to 10.0. The present invention can provide a composition including (a) thiopyridinone compound(s) with increased stability of the (a) thiopyridinone compound(s), even when the composition is maintained for a relatively long period of time under elevated temperature.
• [EN] PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS<br/>[FR] PROCÉDÉ DE DÉPIGMENTATION DE MATIÈRES KÉRATINIQUES AU MOYEN DE COMPOSÉS DE THIOPYRIDINONE
  申请人：OREAL

  公开号：WO2017102349A1

  公开（公告）日：2017-06-22

  The invention relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, in particular the skin, comprising the application of a cosmetic composition comprising a compound of formula (I): compound of formula (I): (I) The invention also relates to the novel compounds of formula (I), to the compositions containing same and also to the cosmetic use of a compound (I) as an agent for bleaching, lightening and/or depigmenting keratin materials.

  该发明涉及一种用于脱色、美白和/或漂白角蛋白材料，特别是皮肤的化妆过程，包括应用包含化合物的化妆品组合物的步骤：化合物的化学式为(I)。该发明还涉及化学式(I)的新化合物，含有该化合物的组合物，以及将化合物(I)作为漂白、美白和/或脱色角蛋白材料的剂的化妆用途。