(R)-5-((S)-4,5-dimethoxy-3-oxo-phthalan-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline-9-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 邻苯二甲酸异喹啉类
• 英文名称: (R)-5-((S)-4,5-dimethoxy-3-oxo-phthalan-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline-9-carboxylic acid methyl ester
• 英文别名: (R)-5-((S)-4,5-Dimethoxy-3-oxo-phthalan-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isochinolin-9-carbonsaeure-methylester；methyl (5R)-5-[(1S)-4,5-dimethoxy-3-oxo-1H-2-benzofuran-1-yl]-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline-9-carboxylate
• 化学式: C₂₄H₂₅NO₉
• 分子量: 471.464
• InChiKey: FNPHUIGXMYCCSG-MSOLQXFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  氯甲酸乙酯 、 那可汀 生成 (R)-5-((S)-4,5-dimethoxy-3-oxo-phthalan-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline-9-carboxylic acid methyl ester
  参考文献：
  名称：

  Hadacek; Sapara, Spisy Vydavane Prirodovedeckou Fakultou Massarykovy University, 1959, # 320, p. 23,41, 43

  摘要：

  DOI：

文献信息

• Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition
  申请人：Acuff Cory

  公开号：US20110274651A1

  公开（公告）日：2011-11-10

  Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of viruses and other microbes within mammalian and other cells by inhibiting the cytoplasmic transport mechanisms within the cells. The compositions described herein include an effective amount of the noscapine analogues described herein, along with a pharmaceutically acceptable carrier or excipient. The compositions can also include one or more additional antimicrobial compounds.

  本发明公开了用于治疗或预防传染病、抑制微生物在哺乳动物细胞内移动和抑制微生物复制能力的组合物和方法。该组合物包括各种诺斯卡平类似物，能够通过抑制细胞内的胞质转运机制，阻止病毒和其他微生物在哺乳动物和其他细胞内移动。本发明所描述的组合物包括所述诺斯卡平类似物的有效量，以及药学上可接受的载体或赋形剂。该组合物还可以包括一个或多个额外的抗微生物化合物。
• Hadacek; Sapara, Spisy Vydavane Prirodovedeckou Fakultou Massarykovy University, 1959, # 320, p. 23,41, 43
  作者：Hadacek、Sapara

  DOI：——

  日期：——